Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.
Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB.
Gokhman D, et al. Among authors: rohatgi r.
Nat Genet. 2021 Apr;53(4):467-476. doi: 10.1038/s41588-021-00804-3. Epub 2021 Mar 17.
Nat Genet. 2021.
PMID: 33731941
Free PMC article.
However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells to study gene expression separating these species. ...
However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induc …