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RPP25 as a Prognostic-Related Biomarker That Correlates With Tumor Metabolism in Glioblastoma.
Xiao D, Wu J, Zhao H, Jiang X, Nie C. Xiao D, et al. Front Oncol. 2022 Jan 12;11:714904. doi: 10.3389/fonc.2021.714904. eCollection 2021. Front Oncol. 2022. PMID: 35096558 Free PMC article.
RPP25, a 25 kDa protein subunit of ribonuclease P (RNase P), is a protein-coding gene. ...Analysis of RPP25 expression in GBM alone revealed that RPP25 was significantly downregulated in GBM compared with normal tissue. ...
RPP25, a 25 kDa protein subunit of ribonuclease P (RNase P), is a protein-coding gene. ...Analysis of RPP25 expression in GBM …
Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.
Yin C, Bai G, Zhang Y, Huang J. Yin C, et al. J Struct Biol. 2021 Jun;213(2):107704. doi: 10.1016/j.jsb.2021.107704. Epub 2021 Feb 9. J Struct Biol. 2021. PMID: 33571640
Here we report the crystal structure of the P3 domain of RMRP in complex with the RPP20 and RPP25 proteins of human RNase MRP, which shows that the P3 RNA binds to a conserved positively-charged surface of the RPP20-RPP25 heterodimer through its distal stem and inte …
Here we report the crystal structure of the P3 domain of RMRP in complex with the RPP20 and RPP25 proteins of human RNase MRP, which …
Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.
Mahler M, Gascon C, Patel S, Ceribelli A, Fritzler MJ, Swart A, Chan EK, Satoh M. Mahler M, et al. Arthritis Res Ther. 2013 Apr 12;15(2):R50. doi: 10.1186/ar4210. Arthritis Res Ther. 2013. PMID: 23587095 Free PMC article.
To define the cutoff of the CLIA, anti-Th/To IP positive and negative sera were tested using the anti-Rpp25 CLIA. At the cutoff selected by receiver operating characteristic (ROC) analysis 8/8 (100.0%) of the anti-Th/To positive sera but only 2/367 (0.5%) of the controls w …
To define the cutoff of the CLIA, anti-Th/To IP positive and negative sera were tested using the anti-Rpp25 CLIA. At the cutoff selec …
RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.
Huang HS, Cheung I, Akbarian S. Huang HS, et al. Autism Res. 2010 Aug;3(4):153-61. doi: 10.1002/aur.141. Autism Res. 2010. PMID: 20632321
Unexpectedly, and in contrast to peripheral tissues, levels of RPP25 protein remained undetectable in fetal and adult cerebral cortex. Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain di …
Unexpectedly, and in contrast to peripheral tissues, levels of RPP25 protein remained undetectable in fetal and adult cerebral cortex …
CircASAP1 promotes the development of cervical cancer through sponging miR-338-3p to upregulate RPP25.
Feng L, Zhao M, Wu A. Feng L, et al. Anticancer Drugs. 2022 Jan 1;33(1):e155-e165. doi: 10.1097/CAD.0000000000001167. Anticancer Drugs. 2022. PMID: 34407047
The protein expression levels of cyclin D1, proliferating cell nuclear antigen, and RPP25 were assessed by western blot assay. Flow cytometry assays were used to determine the apoptosis and cell cycle distribution of cervical cancer cells. ...The interaction relationship b …
The protein expression levels of cyclin D1, proliferating cell nuclear antigen, and RPP25 were assessed by western blot assay. Flow c …
Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests.
Mahler M, Satoh M, Hudson M, Baron M, Chan JY, Chan EK, Wick J, Fritzler MJ; Canadian Scleroderma Research Group. Mahler M, et al. J Rheumatol. 2014 Jul;41(7):1334-43. doi: 10.3899/jrheum.131450. Epub 2014 Jun 15. J Rheumatol. 2014. PMID: 24931955
Samples without antibodies to extractable nuclear antigens (ENA; n = 53, ANA+/ENA-), were analyzed by immunoprecipitation (IP) and metabolically labeled proteins and for anti-Rpp25 antibodies (n = 50) by a chemiluminescent immunoassay (CLIA) and Rpp25 ELISA. ...Assa …
Samples without antibodies to extractable nuclear antigens (ENA; n = 53, ANA+/ENA-), were analyzed by immunoprecipitation (IP) and metabolic …
Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.
Chan CW, Kiesel BR, Mondragón A. Chan CW, et al. J Mol Biol. 2018 May 11;430(10):1403-1416. doi: 10.1016/j.jmb.2018.03.029. Epub 2018 Apr 4. J Mol Biol. 2018. PMID: 29625199 Free PMC article.
A unique feature of eukaryotic RNase P/MRP is the presence of two relatively long and unpaired internal loops within the P3 region of their RNA subunit bound by a heterodimeric protein complex, Rpp20/Rpp25. Here we present a crystal structure of the human Rpp20/Rpp25 …
A unique feature of eukaryotic RNase P/MRP is the presence of two relatively long and unpaired internal loops within the P3 region of their …
Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P.
Guerrier-Takada C, Eder PS, Gopalan V, Altman S. Guerrier-Takada C, et al. RNA. 2002 Mar;8(3):290-5. doi: 10.1017/s1355838202027954. RNA. 2002. PMID: 12003489 Free PMC article.
We report here the cloning and immuno-biochemical analysis of Rpp25, another protein subunit of RNase P. Polyclonal rabbit antibodies raised against recombinant Rpp25 recognize their corresponding antigens in RNase P-containing fractions purified from HeLa cells, an …
We report here the cloning and immuno-biochemical analysis of Rpp25, another protein subunit of RNase P. Polyclonal rabbit antibodies …
LINC00319 promotes migration, invasion and epithelial-mesenchymal transition process in cervical cancer by regulating miR-3127-5p/RPP25 axis.
Yang J, Hou S, Liang B. Yang J, et al. In Vitro Cell Dev Biol Anim. 2020 Feb;56(2):145-153. doi: 10.1007/s11626-019-00425-5. Epub 2020 Jan 15. In Vitro Cell Dev Biol Anim. 2020. PMID: 31942724
Additionally, miR-3127-5p mimics or RPP25 insufficiency could offset the encouraging effects of LINC00319 overexpression on migration, invasion and EMT process in cervical cancer. Generally speaking, LINC00319 promotes migration, invasion and EMT process in cervical cancer …
Additionally, miR-3127-5p mimics or RPP25 insufficiency could offset the encouraging effects of LINC00319 overexpression on migration …
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes.
Köferle A, Schlattl A, Hörmann A, Thatikonda V, Popa A, Spreitzer F, Ravichandran MC, Supper V, Oberndorfer S, Puchner T, Wieshofer C, Corcokovic M, Reiser C, Wöhrle S, Popow J, Pearson M, Martinez J, Weitzer S, Mair B, Neumüller RA. Köferle A, et al. Cell Rep. 2022 Apr 12;39(2):110636. doi: 10.1016/j.celrep.2022.110636. Cell Rep. 2022. PMID: 35417719 Free article.
Our analysis reveals >2,000 candidate dependencies, several of which we validate experimentally, including CSTF2-CSTF2T, DNAJC15-DNAJC19, FAM50A-FAM50B, and RPP25-RPP25L. We provide evidence that RPP25L can physically and functionally compensate for the absence of RP …
Our analysis reveals >2,000 candidate dependencies, several of which we validate experimentally, including CSTF2-CSTF2T, DNAJC15-DNAJC19, …
35 results