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Year Number of Results
1992 1
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2002 5
2003 5
2004 4
2005 4
2006 7
2007 2
2008 5
2009 10
2010 6
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2013 7
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162 results

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Page 1
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.
Zheng C, Liang J, Yu S, Xu H, Dai L, Xu D. Zheng C, et al. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):333-344. doi: 10.4196/kjpp.2023.27.4.333. Korean J Physiol Pharmacol. 2023. PMID: 37386831 Free PMC article.
Elevated expressions of circ-SNX27 and RPN1 as well as a reduced miR-375 expression were observed among HCC cells and HCC patient tumor specimens. ...Nonetheless, the promotive effect of miR-375 silencing was reversible via the knockdown of circ-SNX27 or RPN1. This …
Elevated expressions of circ-SNX27 and RPN1 as well as a reduced miR-375 expression were observed among HCC cells and HCC patient tum …
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE. Liang JR, et al. Cell. 2020 Mar 19;180(6):1160-1177.e20. doi: 10.1016/j.cell.2020.02.017. Epub 2020 Mar 10. Cell. 2020. PMID: 32160526 Free PMC article.
The UFL1 ligase is brought to the ER surface by DDRGK1 to UFMylate RPN1 and RPL26 and preferentially targets ER sheets for degradation, analogous to PINK1-Parkin regulation during mitophagy. ...
The UFL1 ligase is brought to the ER surface by DDRGK1 to UFMylate RPN1 and RPL26 and preferentially targets ER sheets for degradatio …
RPN1 promotes the proliferation and invasion of breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway.
Shen WJ, Zhang Y. Shen WJ, et al. Discov Oncol. 2024 Feb 1;15(1):25. doi: 10.1007/s12672-024-00875-8. Discov Oncol. 2024. PMID: 38302629 Free PMC article.
After down-regulating RPN1 expression by shRNA, the effects of RPN1 on the proliferation, migration and invasion of MCF7 cells were examined. Mechanistically, we assessed the effect of RPN1 on the PI3K/ AKT/mTOR signaling pathway. We found that RPN1 le …
After down-regulating RPN1 expression by shRNA, the effects of RPN1 on the proliferation, migration and invasion of MCF7 cells …
Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.
Liu X, Xiao W, Zhang Y, Wiley SE, Zuo T, Zheng Y, Chen N, Chen L, Wang X, Zheng Y, Huang L, Lin S, Murphy AN, Dixon JE, Xu P, Guo X. Liu X, et al. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):328-336. doi: 10.1073/pnas.1912531117. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2020. PMID: 31843888 Free PMC article.
Here, we have characterized 1 of the most frequently detected proteasome phosphosites, namely Ser361 of Rpn1, a base subunit of the 19S regulatory particle. Using a variety of approaches including CRISPR/Cas9-mediated gene editing and quantitative mass spectrometry, we fou …
Here, we have characterized 1 of the most frequently detected proteasome phosphosites, namely Ser361 of Rpn1, a base subunit of the 1 …
Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.
Rosenzweig R, Bronner V, Zhang D, Fushman D, Glickman MH. Rosenzweig R, et al. J Biol Chem. 2012 Apr 27;287(18):14659-71. doi: 10.1074/jbc.M111.316323. Epub 2012 Feb 8. J Biol Chem. 2012. PMID: 22318722 Free PMC article.
We found that two shuttles of this class, Rad23 and Dsk2, dock at two different receptor sites embedded within a single subunit of the 19 S proteasome regulatory particle, Rpn1. Their association/dissociation constants and affinities for Rpn1 are similar. ...By bind …
We found that two shuttles of this class, Rad23 and Dsk2, dock at two different receptor sites embedded within a single subunit of the 19 S …
Disulfidptosis-related Protein RPN1 May be a Novel Anti-osteoporosis Target of Kaempferol.
Pan C, Zhang C, Lin Z, Liang Z, Cui Y, Shang Z, Wei Y, Chen F. Pan C, et al. Comb Chem High Throughput Screen. 2024 Jan 10. doi: 10.2174/0113862073273655231213070619. Online ahead of print. Comb Chem High Throughput Screen. 2024. PMID: 38213143
The impact of RPN1 on immune alterations and biological processes was explored. ...Four miRNAs and 17 lncRNAs associated with RPN1 were identified. Kaempferol exhibited high binding affinity (-7.2 kcal/mol) and good stability towards the RPN1. ...
The impact of RPN1 on immune alterations and biological processes was explored. ...Four miRNAs and 17 lncRNAs associated with RPN1 …
Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1.
Boughton AJ, Zhang D, Singh RK, Fushman D. Boughton AJ, et al. J Biol Chem. 2021 Jan-Jun;296:100450. doi: 10.1016/j.jbc.2021.100450. Epub 2021 Feb 20. J Biol Chem. 2021. PMID: 33617881 Free PMC article.
Rpn1 appears to contain multiple Ub/UBL-binding sites, theoretically as many as one for each of its hallmark proteasome/cyclosome repeats. Remarkably, we also find that binding sites on Rpn1 can be shared among Ub and UBL species, while proteasomal receptors Rpn1 …
Rpn1 appears to contain multiple Ub/UBL-binding sites, theoretically as many as one for each of its hallmark proteasome/cyclosome rep …
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ. Shi Y, et al. Science. 2016 Feb 19;351(6275):10.1126/science.aad9421 aad9421. doi: 10.1126/science.aad9421. Science. 2016. PMID: 26912900 Free PMC article.
Here, we found that the five known proteasomal ubiquitin receptors in yeast are collectively nonessential for ubiquitin recognition and identified a sixth receptor, Rpn1. A site ( T1: ) in the Rpn1 toroid recognized ubiquitin and ubiquitin-like ( UBL: ) domains of s …
Here, we found that the five known proteasomal ubiquitin receptors in yeast are collectively nonessential for ubiquitin recognition and iden …
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer.
Ding J, Xu J, Deng Q, Ma W, Zhang R, He X, Liu S, Zhang L. Ding J, et al. Front Oncol. 2021 Oct 27;11:722624. doi: 10.3389/fonc.2021.722624. eCollection 2021. Front Oncol. 2021. PMID: 34778038 Free PMC article.
The protein expression level of RPN1 was also upregulated in breast cancer. Higher expression of RPN1 was correlated with worse clinical features and poorer prognosis. ...Our results identified the oncogenic function of RPN1 in breast cancer, implying that …
The protein expression level of RPN1 was also upregulated in breast cancer. Higher expression of RPN1 was correlated with wors …
Proteasome subunit Rpn1 binds ubiquitin-like protein domains.
Elsasser S, Gali RR, Schwickart M, Larsen CN, Leggett DS, Müller B, Feng MT, Tübing F, Dittmar GA, Finley D. Elsasser S, et al. Nat Cell Biol. 2002 Sep;4(9):725-30. doi: 10.1038/ncb845. Nat Cell Biol. 2002. PMID: 12198498
A second UBL protein, Dsk2, competes with Rad23 for proteasome binding, which suggests that the LRR-like domain of Rpn1 may participate in the recognition of several ligands of the proteasome. We propose that the LRR domain of Rpn1 may be positioned in the base to a …
A second UBL protein, Dsk2, competes with Rad23 for proteasome binding, which suggests that the LRR-like domain of Rpn1 may participa …
162 results