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Molecular control of Tfh-cell differentiation by Roquin family proteins.
Heissmeyer V, Vogel KU. Heissmeyer V, et al. Immunol Rev. 2013 May;253(1):273-89. doi: 10.1111/imr.12056. Immunol Rev. 2013. PMID: 23550652 Review.
These trans-acting factors have been involved in a number of cell fate decisions, and their mutation is often associated with the development of disease. The RNA-binding protein Roquin-1 has been found to be crucial in the maintenance of peripheral tolerance and the preven …
These trans-acting factors have been involved in a number of cell fate decisions, and their mutation is often associated with the dev …
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M. Janowski R, et al. Nat Commun. 2016 Mar 24;7:11032. doi: 10.1038/ncomms11032. Nat Commun. 2016. PMID: 27010430 Free PMC article.
Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG. Linterman MA, et al. Immunity. 2009 Feb 20;30(2):228-41. doi: 10.1016/j.immuni.2008.12.015. Epub 2009 Feb 12. Immunity. 2009. PMID: 19217324 Free article.
Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory receptor, ICOS, which arose by gene duplication, are critical for affinity maturation and memory antibody responses. ICOS ligand …
Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costi …