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RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.
Chen L, Zhang W, Chen D, Yang Q, Sun S, Dai Z, Li Z, Liang X, Chen C, Jiao Y, Zhi L, Zhao L, Zhang J, Liu X, Zhao J, Li M, Wang Y, Qi Y. Chen L, et al. Signal Transduct Target Ther. 2023 Apr 21;8(1):159. doi: 10.1038/s41392-023-01367-x. Signal Transduct Target Ther. 2023. PMID: 37080995 Free PMC article.
The level of RBM4 was specifically elevated in ESCC compared to normal tissues, and RBM4 overexpression promoted the malignant phenotype. ...Therefore, such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of g …
The level of RBM4 was specifically elevated in ESCC compared to normal tissues, and RBM4 overexpression promoted the malignant …
Nuclear Aurora kinase A switches m(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4.
Li S, Qi Y, Yu J, Hao Y, He B, Zhang M, Dai Z, Jiang T, Li S, Huang F, Chen N, Wang J, Yang M, Liang D, An F, Zhao J, Fan W, Pan Y, Deng Z, Luo Y, Guo T, Peng F, Hou Z, Wang C, Zheng F, Xu L, Xu J, Wen Q, Jin B, Wang Y, Liu Q. Li S, et al. Signal Transduct Target Ther. 2022 Apr 1;7(1):97. doi: 10.1038/s41392-022-00905-3. Signal Transduct Target Ther. 2022. PMID: 35361747 Free PMC article.
Here, we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m(6)A reader YTHDC1 in lung cancer. Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing, specifically triggering …
Here, we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed b …
RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.
Wang L, Zhang X, Sheng J, Chen L, Zhi L, Zheng Q, Qi Y, Wang L, Zhang J, Zhao J, Wang Y, Liu SX, Sun MZ, Zhang W. Wang L, et al. Cell Death Dis. 2023 Jan 13;14(1):27. doi: 10.1038/s41419-023-05563-z. Cell Death Dis. 2023. PMID: 36639375 Free PMC article.
Meanwhile, RBM4 ablation inhibited cancer cell progression both in vitro and in vivo. ...Moreover, either SERPINE1 inhibitor or miR-1244 mimics attenuated the RBM4 depletion-induced senescence. Altogether, our study revealed a novel mechanism of RBM4 in the r …
Meanwhile, RBM4 ablation inhibited cancer cell progression both in vitro and in vivo. ...Moreover, either SERPINE1 inhibitor or miR-1 …
RBM4 inhibits the growth of clear cell renal cell carcinoma by enhancing the stability of p53 mRNA.
Jian W, Xue W, Wang T, Yu Y, Cai L, Meng Y, Xia Z, Zhang C. Jian W, et al. Mol Carcinog. 2023 Apr;62(4):464-478. doi: 10.1002/mc.23499. Epub 2022 Dec 31. Mol Carcinog. 2023. PMID: 36585906
Therefore, the present study investigated the expression and biological function of RBM4 in ccRCC. Analysis of the differential expression of RBM4 and its relationship with clinicopathological features using ccRCC samples data from TCGA database deminstrated that …
Therefore, the present study investigated the expression and biological function of RBM4 in ccRCC. Analysis of the differential expre …
Multiple roles of RBM4 in muscle cell differentiation.
Lin JC, Tarn WY. Lin JC, et al. Front Biosci (Schol Ed). 2012 Jan 1;4(1):181-9. doi: 10.2741/260. Front Biosci (Schol Ed). 2012. PMID: 22202052 Free article. Review.
Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In this review, we discuss recent data regarding how RBM4....
Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In th …
RBM4: a multifunctional RNA-binding protein.
Markus MA, Morris BJ. Markus MA, et al. Int J Biochem Cell Biol. 2009 Apr;41(4):740-3. doi: 10.1016/j.biocel.2008.05.027. Epub 2008 Aug 3. Int J Biochem Cell Biol. 2009. PMID: 18723113 Review.
RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells. It is now clear that RBM4 is an RNA-binding protein involved in diverse cellular proc …
RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years dat …
RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis.
Huangfu N, Zheng W, Xu Z, Wang S, Wang Y, Cheng J, Li Z, Cheng K, Zhang S, Chen X, Zhu J. Huangfu N, et al. Int Immunopharmacol. 2020 Jun;83:106432. doi: 10.1016/j.intimp.2020.106432. Epub 2020 Apr 2. Int Immunopharmacol. 2020. PMID: 32248017 Free article.
We found that IFN-gamma, but not IL-4, stimulation decreased RBM4 expression in macrophages, and RBM4 overexpression inhibits IFN-gamma-induced M1 macrophage polarization. ...Collectively, the current study firstly reports that RBM4 regulates M1 macrophages p …
We found that IFN-gamma, but not IL-4, stimulation decreased RBM4 expression in macrophages, and RBM4 overexpression inhibits …
RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression.
Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. Tarn WY, et al. Mol Biol Cell. 2016 May 15;27(10):1676-83. doi: 10.1091/mbc.E15-11-0798. Epub 2016 Mar 23. Mol Biol Cell. 2016. PMID: 27009199 Free PMC article.
RBM4 also has been implicated in neurogenesis in the mouse embryonic brain. ...Neurite outgrowth defects of RBM4-depleted neurons were rescued by RBM4-induced exon 9-lacking Numb isoforms. ...
RBM4 also has been implicated in neurogenesis in the mouse embryonic brain. ...Neurite outgrowth defects of RBM4-depleted neur …
RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells.
Wang WY, Quan W, Yang F, Wei YX, Chen JJ, Yu H, Xie J, Zhang Y, Li ZF. Wang WY, et al. Mol Genet Genomics. 2020 Jan;295(1):95-106. doi: 10.1007/s00438-019-01606-3. Epub 2019 Sep 5. Mol Genet Genomics. 2020. PMID: 31489484
Here, the cell biology, gene expression profile and alternative splicing pattern of HeLa cells with RBM4 overexpression (RBM-OE) were compared with the control. The results showed that RBM4-OE inhibited proliferation. ...These results indicated that RBM4 can …
Here, the cell biology, gene expression profile and alternative splicing pattern of HeLa cells with RBM4 overexpression (RBM-OE) were …
RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.
D D, Hung KY, Tarn WY. D D, et al. Mol Cell Biol. 2018 May 29;38(12):e00007-18. doi: 10.1128/MCB.00007-18. Print 2018 Jun 15. Mol Cell Biol. 2018. PMID: 29581187 Free PMC article.
RBM4 directly counteracted the effect of PTBP1 on exon 7/8 selection. Finally, we showed that the full-length Dab1, but not exon 7/8-truncated Dab1, rescued neuronal migration defects in RBM4-depleted neurons, indicating that RBM4 plays a role in neuronal mig …
RBM4 directly counteracted the effect of PTBP1 on exon 7/8 selection. Finally, we showed that the full-length Dab1, but not exon 7/8- …
91 results