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Year Number of Results
1994 1
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1999 1
2000 2
2001 1
2002 1
2004 2
2005 2
2006 4
2007 4
2008 2
2009 4
2010 6
2011 3
2012 3
2013 5
2014 5
2015 1
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2020 7
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88 results

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RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.
Karthikeyan S, Casey PJ, Wang M. Karthikeyan S, et al. Breast Cancer Res. 2022 Oct 28;24(1):72. doi: 10.1186/s13058-022-01564-6. Breast Cancer Res. 2022. PMID: 36307864 Free PMC article.
Consistently, RAB4A suppression abolished the cancer cells' self-renewal and tumor forming ability. In terms of downstream signaling, we found that RAB4A regulation of EMT is achieved through its control of activation of the RAC1 GTPase. ...
Consistently, RAB4A suppression abolished the cancer cells' self-renewal and tumor forming ability. In terms of downstream signaling, …
Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles.
Nag S, Rani S, Mahanty S, Bissig C, Arora P, Azevedo C, Saiardi A, van der Sluijs P, Delevoye C, van Niel G, Raposo G, Setty SRG. Nag S, et al. J Cell Sci. 2018 Sep 20;131(18):jcs216226. doi: 10.1242/jcs.216226. J Cell Sci. 2018. PMID: 30154210 Free PMC article.
Here, RNAi screening in melanocytes revealed that knockdown of Rab4A results in defective melanosome maturation. Rab4A-depletion increases the number of vacuolar endosomes and disturbs the cargo sorting, which in turn lead to the mislocalization of melanosomal prote …
Here, RNAi screening in melanocytes revealed that knockdown of Rab4A results in defective melanosome maturation. Rab4A-depleti …
Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis.
Mruk DD, Lau AS, Sarkar O, Xia W. Mruk DD, et al. J Androl. 2007 Sep-Oct;28(5):742-54. doi: 10.2164/jandrol.106.002204. Epub 2007 May 9. J Androl. 2007. PMID: 17494101 Free article.
More importantly, the ability of Rab4A to associate with alpha- and beta-catenin increased during Adjudin-induced junction restructuring in the testis, illustrating that Rab4A-catenin interactions are likely to be involved in the disassembly of Sertoli-germ cell con …
More importantly, the ability of Rab4A to associate with alpha- and beta-catenin increased during Adjudin-induced junction restructur …
KDEL Receptor Trafficking to the Plasma Membrane Is Regulated by ACBD3 and Rab4A-GTP.
Tan C, Du Y, Zhu L, Jing S, Gao J, Qian Y, Yue X, Lee I. Tan C, et al. Cells. 2023 Apr 4;12(7):1079. doi: 10.3390/cells12071079. Cells. 2023. PMID: 37048152 Free PMC article.
We report here that ACBD3 depletion results in greatly increased trafficking of KDEL receptor to the PM via Rab4A-positive tubular carriers emanating from the Golgi. Expression of constitutively activated Rab4A mutant (Q72L) increases the surface expression of KDEL …
We report here that ACBD3 depletion results in greatly increased trafficking of KDEL receptor to the PM via Rab4A-positive tubular ca …
Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells.
Cao GJ, Wang D, Zeng ZP, Wang GX, Hu CJ, Xing ZF. Cao GJ, et al. World J Gastrointest Oncol. 2021 Oct 15;13(10):1492-1505. doi: 10.4251/wjgo.v13.i10.1492. World J Gastrointest Oncol. 2021. PMID: 34721780 Free PMC article.
Then we constructed HGC-27 cell lines overexpressing green fluorescent protein-Rab5a or red fluorescent protein-Rab4a and investigated the interaction between Rab5a or Rab4a using Western blotting, co-immunoprecipitation, confocal microscopy, and colocalization anal …
Then we constructed HGC-27 cell lines overexpressing green fluorescent protein-Rab5a or red fluorescent protein-Rab4a and investigate …
In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.
Génier S, Létourneau D, Gauthier E, Picard S, Boisvert M, Parent JL, Lavigne P. Génier S, et al. J Struct Biol. 2020 Oct 1;212(1):107582. doi: 10.1016/j.jsb.2020.107582. Epub 2020 Jul 21. J Struct Biol. 2020. PMID: 32707235
Rab4a is a small GTPase associated with endocytic compartments and a key regulator of early endosomes recycling. ...This suggests that, in a cellular context, Rab4a can self-activate and persist in an activated state in absence of regulatory mechanisms. ...
Rab4a is a small GTPase associated with endocytic compartments and a key regulator of early endosomes recycling. ...This suggests tha
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Huang N, Winans T, Wyman B, Oaks Z, Faludi T, Choudhary G, Lai ZW, Lewis J, Beckford M, Duarte M, Krakko D, Patel A, Park J, Caza T, Sadeghzadeh M, Morel L, Haas M, Middleton F, Banki K, Perl A. Huang N, et al. Nat Commun. 2024 Mar 22;15(1):2598. doi: 10.1038/s41467-024-46441-2. Nat Commun. 2024. PMID: 38519468 Free PMC article.
Rab4A deletion in T cells and pharmacological mTOR blockade restrain CD98 expression, mitochondrial metabolism and lineage skewing and attenuate glomerulonephritis. This study identifies Rab4A-directed endosome traffic as a multilevel regulator of T cell lineage spe
Rab4A deletion in T cells and pharmacological mTOR blockade restrain CD98 expression, mitochondrial metabolism and lineage skewing an
Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles.
Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P. Nagelkerken B, et al. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):593-601. Biochem J. 2000. PMID: 10698684 Free PMC article.
Rabaptin4 preferentially interacts with rab4a-GTP and to a lesser extent with rab5aGTP. We identified a rab4a-binding domain in the N-terminal region of rabaptin4, and two binding sites for rab5, including a novel N-terminal rab5a-binding site. Rabaptin4 is a cytoso …
Rabaptin4 preferentially interacts with rab4a-GTP and to a lesser extent with rab5aGTP. We identified a rab4a-binding domain i …
Ras-related Protein in Brain 4A (Rab4A) is Downregulated by miR-496 to inhibit the Progression of Gastric Cancer.
Su R, Su M, Lu Y. Su R, et al. Comb Chem High Throughput Screen. 2023 Oct 16. doi: 10.2174/0113862073260841231010055245. Online ahead of print. Comb Chem High Throughput Screen. 2023. PMID: 38523522
RESULT: In addition, miR-496 down-regulated the expression of Rab4A in AGS cells. The result of the luciferase reporter assay showed that miR-496 could bind to the 3'UTR of Rab4A. ...Rab4A is a potential target in the treatment of gastric cancer....
RESULT: In addition, miR-496 down-regulated the expression of Rab4A in AGS cells. The result of the luciferase reporter assay showed …
88 results