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Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role.
Fiore E, Rago T, Provenzale MA, Scutari M, Ugolini C, Basolo F, Di Coscio G, Berti P, Grasso L, Elisei R, Pinchera A, Vitti P. Fiore E, et al. Among authors: provenzale ma. Endocr Relat Cancer. 2009 Dec;16(4):1251-60. doi: 10.1677/ERC-09-0036. Epub 2009 Jun 15. Endocr Relat Cancer. 2009. PMID: 19528244
L-thyroxine-treated patients with nodular goiter have lower serum TSH and lower frequency of papillary thyroid cancer: results of a cross-sectional study on 27 914 patients.
Fiore E, Rago T, Provenzale MA, Scutari M, Ugolini C, Basolo F, Di Coscio G, Miccoli P, Grasso L, Pinchera A, Vitti P. Fiore E, et al. Among authors: provenzale ma. Endocr Relat Cancer. 2010 Feb 18;17(1):231-9. doi: 10.1677/ERC-09-0251. Print 2010 Mar. Endocr Relat Cancer. 2010. PMID: 20167722
Papillary thyroid cancer, although strongly associated with lymphocytic infiltration on histology, is only weakly predicted by serum thyroid auto-antibodies in patients with nodular thyroid diseases.
Fiore E, Rago T, Scutari M, Ugolini C, Proietti A, Di Coscio G, Provenzale MA, Berti P, Grasso L, Mariotti S, Pinchera A, Vitti P. Fiore E, et al. Among authors: provenzale ma. J Endocrinol Invest. 2009 Apr;32(4):344-51. doi: 10.1007/BF03345725. J Endocrinol Invest. 2009. PMID: 19636204