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Page 1
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.
Czock D, Keller F, Rasche FM, Häussler U. Czock D, et al. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. Clin Pharmacokinet. 2005. PMID: 15634032 Review.
Thus, inflammation and immune response mechanisms may be modified. Nongenomic mechanisms might play an additional role in glucocorticoid pulse therapy. Clinical efficacy depends on glucocorticoid pharmacokinetics and pharmacodynamics. Pharmacokineti
Thus, inflammation and immune response mechanisms may be modified. Nongenomic mechanisms might play an additional role in glucocorticoid
Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.
Hübner M, Hochhaus G, Derendorf H. Hübner M, et al. Immunol Allergy Clin North Am. 2005 Aug;25(3):469-88. doi: 10.1016/j.iac.2005.05.004. Immunol Allergy Clin North Am. 2005. PMID: 16054538 Review.
A comparison of the pharmacodynamics and pharmacokinetics of inhaled corticosteroids is necessary for their assessment. ...HFA-MDI beclomethasone dipropionate (BDP) and ciclesonide are two agents that illustrate this. Low oral bioavailability, rapid systemic
A comparison of the pharmacodynamics and pharmacokinetics of inhaled corticosteroids is necessary for their assessment. ...HFA …
Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs.
Center SA, Warner KL, McCabe J, Foureman P, Hoffmann WE, Erb HN. Center SA, et al. Am J Vet Res. 2005 Feb;66(2):330-41. doi: 10.2460/ajvr.2005.66.330. Am J Vet Res. 2005. PMID: 15757136 Free article. Clinical Trial.
OBJECTIVE: To evaluate the influence of a 1,4-butanedisulfonate stable salt of S-adenosylmethionine (SAMe) administered orally on clinicopathologic and hepatic effects induced by long-term administration of prednisolone in dogs. ...Before and during the trial, numerous var …
OBJECTIVE: To evaluate the influence of a 1,4-butanedisulfonate stable salt of S-adenosylmethionine (SAMe) administered orally on cli …
Colonic spread and serum pharmacokinetics of budesonide foam in patients with mildly to moderately active ulcerative colitis.
Brunner M, Vogelsang H, Greinwald R, Kletter K, Kvaternik H, Schrolnberger C, Eichler HG, Brunner H, Dudczak R, Müller M. Brunner M, et al. Aliment Pharmacol Ther. 2005 Sep 1;22(5):463-70. doi: 10.1111/j.1365-2036.2005.02571.x. Aliment Pharmacol Ther. 2005. PMID: 16128685 Free article. Clinical Trial.
METHODS: Twelve patients (four females, eight males) with acute proctosigmoiditis or left-sided ulcerative colitis were rectally administered a single dose of [99Tcm]-labelled budesonide foam (Budenofalk; Dr Falk Pharma GmbH, Freiburg, Germany) containing 2 mg budesonide i …
METHODS: Twelve patients (four females, eight males) with acute proctosigmoiditis or left-sided ulcerative colitis were rectally administ
Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats.
Kanazu T, Okamura N, Yamaguchi Y, Baba T, Koike M. Kanazu T, et al. Xenobiotica. 2005 Apr;35(4):305-17. doi: 10.1080/00498250500093786. Xenobiotica. 2005. PMID: 16019953
Seven per cent of the midazolam administered reached the systemic circulation. When ketoconazole was given orally to the animals, in conjunction with midazolam, the extraction ratio in the liver decreased from 93% to 77% in the control rats, and the bioavailability …
Seven per cent of the midazolam administered reached the systemic circulation. When ketoconazole was given orally to the anima …
Lack of pharmacokinetic drug-drug interaction between ciclesonide and erythromycin.
Nave R, Drollmann A, Steinijans VW, Zech K, Bethke TD. Nave R, et al. Int J Clin Pharmacol Ther. 2005 Jun;43(6):264-70. doi: 10.5414/cpp43264. Int J Clin Pharmacol Ther. 2005. PMID: 15968883 Clinical Trial.
OBJECTIVE: To investigate whether systemic exposure to desisobutyrylciclesonide (des-CIC) (the pharmacologically active metabolite of ciclesonide) and erythromycin are affected by combined administration of ciclesonide and erythromycin. ...RESULTS: Combined administration …
OBJECTIVE: To investigate whether systemic exposure to desisobutyrylciclesonide (des-CIC) (the pharmacologically active metabolite of …
Monitoring the initial pulmonary absorption of two different beclomethasone dipropionate aerosols employing a human lung reperfusion model.
Freiwald M, Valotis A, Kirschbaum A, McClellan M, Mürdter T, Fritz P, Friedel G, Thomas M, Högger P. Freiwald M, et al. Respir Res. 2005 Feb 24;6(1):21. doi: 10.1186/1465-9921-6-21. Respir Res. 2005. PMID: 15727687 Free PMC article. Clinical Trial.
BACKGROUND: The pulmonary residence time of inhaled glucocorticoids as well as their rate and extend of absorption into systemic circulation are important facets of their efficacy-safety profile. We evaluated a novel approach to elucidate the pulmonary absorption of …
BACKGROUND: The pulmonary residence time of inhaled glucocorticoids as well as their rate and extend of absorption into systemic
Pharmacokinetic interaction between chemotherapy for non-Hodgkin's lymphoma and protease inhibitors in HIV-1-infected patients.
Cruciani M, Gatti G, Vaccher E, Di Gennaro G, Cinelli R, Bassetti M, Tirelli U, Bassetti D. Cruciani M, et al. J Antimicrob Chemother. 2005 Apr;55(4):546-9. doi: 10.1093/jac/dki050. Epub 2005 Feb 22. J Antimicrob Chemother. 2005. PMID: 15728147
OBJECTIVES: We have investigated whether chemotherapy for HIV-related systemic non-Hodgkin's lymphoma (NHL) affects the pharmacokinetics of protease inhibitors. ...Chemotherapy consisted of adriamycin, cyclophosphamide, vincristine and prednisolone (CHOP). Each pati …
OBJECTIVES: We have investigated whether chemotherapy for HIV-related systemic non-Hodgkin's lymphoma (NHL) affects the pharmacoki
Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001).
Blaney SM, Boyett J, Friedman H, Gajjar A, Geyer R, Horowtiz M, Hunt D, Kieran M, Kun L, Packer R, Phillips P, Pollack IF, Prados M, Heideman R. Blaney SM, et al. J Clin Oncol. 2005 Jan 20;23(3):525-31. doi: 10.1200/JCO.2005.06.544. J Clin Oncol. 2005. PMID: 15659498 Clinical Trial.
PURPOSE: A phase I trial of intrathecal (IT) mafosfamide was performed to determine the optimal dose, dose-limiting toxicities, and incidence and severity of other toxicities when administered in association with concomitant multiagent systemic chemotherapy to child …
PURPOSE: A phase I trial of intrathecal (IT) mafosfamide was performed to determine the optimal dose, dose-limiting toxicities, and incidenc …
Pharmacokinetics of liquid calcitriol formulation in advanced solid tumor patients: comparison with caplet formulation.
Muindi JR, Potter DM, Peng Y, Johnson CS, Trump DL. Muindi JR, et al. Cancer Chemother Pharmacol. 2005 Nov;56(5):492-6. doi: 10.1007/s00280-005-1015-2. Epub 2005 May 26. Cancer Chemother Pharmacol. 2005. PMID: 15918041 Clinical Trial.
The non linear relationship between calcitriol (1,25-D(3)) dose and AUC in cancer patients suggests that the commercially available caplet 1,25-D(3) formulation (Rocaltrol) cannot achieve the high systemic exposure associated with antitumor activity in animal models. The p …
The non linear relationship between calcitriol (1,25-D(3)) dose and AUC in cancer patients suggests that the commercially available caplet 1 …
12 results