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Year Number of Results
2001 1
2004 1
2005 2
2006 4
2007 4
2008 1
2009 4
2010 3
2011 1
2014 2
2015 3
2016 1
2017 1
2018 4
2019 2
2020 1
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2023 2
2024 1

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36 results

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Page 1
PLXDC1 Can Be a Biomarker for Poor Prognosis and Immune Evasion in Gastric Cancer.
Li X, Fan Y, Tang M, Li H, Zhang Y, Mi J, Wang Y, Zhao M, Wang Z, Su F. Li X, et al. J Inflamm Res. 2022 Sep 16;15:5439-5455. doi: 10.2147/JIR.S383191. eCollection 2022. J Inflamm Res. 2022. PMID: 36147688 Free PMC article.
Signaling pathway enrichment revealed that high PLXDC1 expression was involved in signaling pathways related to immune activation and stromal activation, and Tumor Immune Dysfunction and Exclusion (TIDE) assessment indicated that high PLXDC1 expression was associate …
Signaling pathway enrichment revealed that high PLXDC1 expression was involved in signaling pathways related to immune activation and …
Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1.
Falchetti ML, D'Alessandris QG, Pacioni S, Buccarelli M, Morgante L, Giannetti S, Lulli V, Martini M, Larocca LM, Vakana E, Stancato L, Ricci-Vitiani L, Pallini R. Falchetti ML, et al. Int J Cancer. 2019 Mar 15;144(6):1331-1344. doi: 10.1002/ijc.31983. Epub 2018 Dec 16. Int J Cancer. 2019. PMID: 30414187 Free PMC article.
Enforced expression of PLXDC1 in U87MG cells promoted brain infiltration along perivascular spaces. Importantly, PLXDC1 inhibition prevented perivascular infiltration and significantly increased the survival of bevacizumab-treated rats. ...
Enforced expression of PLXDC1 in U87MG cells promoted brain infiltration along perivascular spaces. Importantly, PLXDC1 inhibi …
PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium.
Beaty RM, Edwards JB, Boon K, Siu IM, Conway JE, Riggins GJ. Beaty RM, et al. J Neurooncol. 2007 Feb;81(3):241-8. doi: 10.1007/s11060-006-9227-9. Epub 2006 Sep 20. J Neurooncol. 2007. PMID: 17031559
Further subtraction of normal endothelium, bone marrow, white blood cell and other normal tissue transcripts resulted in just three gene transcripts, ANAPC10, PLXDC1(TEM7), and CYP27B1, that are highly specific to GBM-ECs. Immunohistochemistry with an antibody for PLXDC …
Further subtraction of normal endothelium, bone marrow, white blood cell and other normal tissue transcripts resulted in just three gene tra …
Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.
Cheng G, Zhong M, Kawaguchi R, Kassai M, Al-Ubaidi M, Deng J, Ter-Stepanian M, Sun H. Cheng G, et al. Elife. 2014 Dec 23;3:e05401. doi: 10.7554/eLife.05401. Elife. 2014. PMID: 25535841 Free PMC article.
Here we report the identification of transmembrane proteins PLXDC1 and PLXDC2 as cell-surface receptors for PEDF. Using distinct cellular models, we demonstrate their cell type-specific receptor activities through loss of function and gain of function studies. ...
Here we report the identification of transmembrane proteins PLXDC1 and PLXDC2 as cell-surface receptors for PEDF. Using distinct cell …
Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer.
Kim GH, Won JE, Byeon Y, Kim MG, Wi TI, Lee JM, Park YY, Lee JW, Kang TH, Jung ID, Shin BC, Ahn HJ, Lee YJ, Sood AK, Han HD, Park YM. Kim GH, et al. Drug Deliv. 2018 Nov;25(1):1394-1402. doi: 10.1080/10717544.2018.1480672. Drug Deliv. 2018. PMID: 29890852 Free PMC article.
Herein, we developed PLXDC1 small interfering siRNA (siRNA)-incorporated chitosan nanoparticle (CH-NP/siRNA) coated with hyaluronic acid (HA) to target the CD44 receptor on tumor endothelial cells. ...The selective binding of HA-CH-NP/siRNA to CD44-positive tumor endotheli …
Herein, we developed PLXDC1 small interfering siRNA (siRNA)-incorporated chitosan nanoparticle (CH-NP/siRNA) coated with hyaluronic a …
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV).
Großkopf AK, Schlagowski S, Fricke T, Ensser A, Desrosiers RC, Hahn AS. Großkopf AK, et al. PLoS Pathog. 2021 Mar 3;17(3):e1008979. doi: 10.1371/journal.ppat.1008979. eCollection 2021 Mar. PLoS Pathog. 2021. PMID: 33657166 Free PMC article.
Mutation of this motif abrogated the interaction with Plxdc1/2 and reduced RRV infection in a cell type-specific manner. ...Further, Plxdc1/2 usage defines an important biological difference between KSHV and RRV....
Mutation of this motif abrogated the interaction with Plxdc1/2 and reduced RRV infection in a cell type-specific manner. ...Further, …
Prenatal exposure to per- and polyfluoroalkyl substances and DNA methylation in the placenta: A prospective cohort study.
Xie Z, Sun S, Ji H, Miao M, He W, Song X, Cao W, Wu Q, Liang H, Yuan W. Xie Z, et al. J Hazard Mater. 2024 Feb 5;463:132845. doi: 10.1016/j.jhazmat.2023.132845. Epub 2023 Oct 24. J Hazard Mater. 2024. PMID: 37898083
PFOA was associated with hypomethylation of IRS4 and PLXDC1, and PFNA was associated with PLXDC1 hypomethylation. There were positive associations of CHST7 methylation with PFTrDA and IRS4 methylation with PFDoA and PFTrDA. PLXDC1 hypomethylation mediated the …
PFOA was associated with hypomethylation of IRS4 and PLXDC1, and PFNA was associated with PLXDC1 hypomethylation. There were p …
Tumor endothelium is characterized by a matrix remodeling signature.
van Beijnum JR, Petersen K, Griffioen AW. van Beijnum JR, et al. Front Biosci (Schol Ed). 2009 Jun 1;1(1):216-25. doi: 10.2741/S21. Front Biosci (Schol Ed). 2009. PMID: 19482697 Free article. Review.
Several genes, including collagens 4A1, 4A2 and 1A1, SPARC, THY1 and MMP9 are overexpressed in the endothelium of more than one tumor type, whereas plexin domain containing 1 (PLXDC1), previously known as TEM7, is overexpressed in EC of all four tumor types....
Several genes, including collagens 4A1, 4A2 and 1A1, SPARC, THY1 and MMP9 are overexpressed in the endothelium of more than one tumor type, …
36 results