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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1991 1
1994 2
1995 2
1996 4
1997 3
1998 8
1999 4
2000 10
2001 8
2002 23
2003 28
2004 49
2005 60
2006 77
2007 71
2008 100
2009 115
2010 125
2011 169
2012 171
2013 160
2014 174
2015 191
2016 170
2017 188
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3,096 results

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Page 1
Polo-like kinase 1 (PLK1) signaling in cancer and beyond.
Iliaki S, Beyaert R, Afonina IS. Iliaki S, et al. Biochem Pharmacol. 2021 Nov;193:114747. doi: 10.1016/j.bcp.2021.114747. Epub 2021 Aug 26. Biochem Pharmacol. 2021. PMID: 34454931 Review.
Furthermore, deregulation of PLK1 results in chromosome instability and aneuploidy. PLK1 is overexpressed in many cancers, which is associated with poor prognosis, making PLK1 an attractive target for cancer treatment. ...In this review we will highlight the …
Furthermore, deregulation of PLK1 results in chromosome instability and aneuploidy. PLK1 is overexpressed in many cancers, whi …
Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy.
Zhang Z, Cheng L, Li J, Qiao Q, Karki A, Allison DB, Shaker N, Li K, Utturkar SM, Atallah Lanman NM, Rao X, Rychahou P, He D, Konieczny SF, Wang C, Shao Q, Evers BM, Liu X. Zhang Z, et al. Cancer Res. 2022 Oct 4;82(19):3532-3548. doi: 10.1158/0008-5472.CAN-22-0018. Cancer Res. 2022. PMID: 35950917 Free PMC article.
In addition, the role of Plk1 in PDAC progression requires further elucidation. Here, we showed that Plk1 was associated with poor outcomes in patients with PDAC. ...Together, Plk1 suppresses PDAC progression and inhibits NF-kappaB activity, and targeting …
In addition, the role of Plk1 in PDAC progression requires further elucidation. Here, we showed that Plk1 was associated with …
PLK1 inhibition-based combination therapies for cancer management.
Su S, Chhabra G, Singh CK, Ndiaye MA, Ahmad N. Su S, et al. Transl Oncol. 2022 Feb;16:101332. doi: 10.1016/j.tranon.2021.101332. Epub 2021 Dec 29. Transl Oncol. 2022. PMID: 34973570 Free PMC article. Review.
Recently, combination therapies targeting multiple pathways are being tested for cancer management. In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy …
Recently, combination therapies targeting multiple pathways are being tested for cancer management. In this review, we first discuss structu …
Multiple Roles of PLK1 in Mitosis and Meiosis.
Kalous J, Aleshkina D. Kalous J, et al. Cells. 2023 Jan 2;12(1):187. doi: 10.3390/cells12010187. Cells. 2023. PMID: 36611980 Free PMC article. Review.
In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regulating mRNA translation. However, knowledge of the role of PLK1 in the regulation of meiosis remains limited....
In this review, we summarize the functions of PLK1 in mitosis, meiosis, and cytokinesis and focus on the role of PLK1 in regul …
Present and Future Perspective on PLK1 Inhibition in Cancer Treatment.
Chiappa M, Petrella S, Damia G, Broggini M, Guffanti F, Ricci F. Chiappa M, et al. Front Oncol. 2022 Jun 2;12:903016. doi: 10.3389/fonc.2022.903016. eCollection 2022. Front Oncol. 2022. PMID: 35719948 Free PMC article. Review.
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. ...Recently, new roles of PLK1 have been reported in literature on its implication in the regulation of inflammation and immunological responses. ...
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. ...Recently, new roles of …
PLK1, A Potential Target for Cancer Therapy.
Liu Z, Sun Q, Wang X. Liu Z, et al. Transl Oncol. 2017 Feb;10(1):22-32. doi: 10.1016/j.tranon.2016.10.003. Epub 2016 Nov 24. Transl Oncol. 2017. PMID: 27888710 Free PMC article. Review.
Dysfunction of PLK1 may promote cancerous transformation and drive its progression. ...Thus, PLK1 is expected to be a potential target for cancer therapy. In this article, we examined PLK1's structural characteristics, its regulatory roles in cell mitosis, …
Dysfunction of PLK1 may promote cancerous transformation and drive its progression. ...Thus, PLK1 is expected to be a potentia …
PLK1 regulating chemoradiotherapy sensitivity of esophageal squamous cell carcinoma through pentose phosphate pathway/ferroptosis.
Zhao M, Lu T, Bi G, Hu Z, Liang J, Bian Y, Feng M, Zhan C. Zhao M, et al. Biomed Pharmacother. 2023 Dec;168:115711. doi: 10.1016/j.biopha.2023.115711. Epub 2023 Oct 24. Biomed Pharmacother. 2023. PMID: 37879213 Free article.
ESCC patients from the GEO database and our center, YY1 and PLK1 expression were significantly positively-correlated, and the survival of patients with high expression of PLK1 was significantly shorter. ...Transcription factor YY1 has a positive regulatory effect on …
ESCC patients from the GEO database and our center, YY1 and PLK1 expression were significantly positively-correlated, and the surviva …
PLK1-mediated phosphorylation of beta-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC.
Kim DE, Shin SB, Kim CH, Kim YB, Oh HJ, Yim H. Kim DE, et al. Theranostics. 2023 Feb 5;13(3):1198-1216. doi: 10.7150/thno.79318. eCollection 2023. Theranostics. 2023. PMID: 36793862 Free PMC article.
In TGF-beta-induced or active PLK1-driven EMT, beta-catenin, PLK1, TSG6, laminin gamma2, and CD44 were concurrently upregulated. beta-catenin is a binding partner of PLK1 in TGF-beta-induced EMT and is phosphorylated at S311. ...Its upregulated stability by p …
In TGF-beta-induced or active PLK1-driven EMT, beta-catenin, PLK1, TSG6, laminin gamma2, and CD44 were concurrently upregulate …
Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.
Gutteridge RE, Ndiaye MA, Liu X, Ahmad N. Gutteridge RE, et al. Mol Cancer Ther. 2016 Jul;15(7):1427-35. doi: 10.1158/1535-7163.MCT-15-0897. Epub 2016 Jun 21. Mol Cancer Ther. 2016. PMID: 27330107 Free PMC article. Review.
Polo-like kinase 1 (Plk1) overexpression has been shown to occur in a wide range of tumors, prompting research and development of Plk1 inhibitors as a means of cancer treatment. This review discusses recent advances in the development of Plk1 inhibitors for c …
Polo-like kinase 1 (Plk1) overexpression has been shown to occur in a wide range of tumors, prompting research and development of …
Recent Progress on the Localization of PLK1 to the Kinetochore and Its Role in Mitosis.
Kim T. Kim T. Int J Mol Sci. 2022 May 8;23(9):5252. doi: 10.3390/ijms23095252. Int J Mol Sci. 2022. PMID: 35563642 Free PMC article. Review.
To dissect the role of PLK1 in mitosis, it is important to understand how PLK1 localizes in the specific region in cells. PLK1 localizes at the kinetochore and is essential in spindle assembly checkpoint and chromosome segregation. ...
To dissect the role of PLK1 in mitosis, it is important to understand how PLK1 localizes in the specific region in cells. P …
3,096 results