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Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis.
Lou J, Wang X, Zhang H, Yu G, Ding J, Zhu X, Li Y, Wu Y, Xu H, Xu H, Gao W, Xiao J, Zhou K. Lou J, et al. Autophagy. 2022 Aug;18(8):1841-1863. doi: 10.1080/15548627.2021.2002109. Epub 2021 Dec 7. Autophagy. 2022. PMID: 34872436 Free PMC article.
Moreover, bioinformatics analysis of the LC-MS results enabled us to focus on the role of PLA2G4E/cPLA2 (phospholipase A2, group IVE) in LMP of the ischemic flaps. In vivo inhibition of PLA2G4E with an adeno-associated virus vector attenuated LMP and necroptosis, an …
Moreover, bioinformatics analysis of the LC-MS results enabled us to focus on the role of PLA2G4E/cPLA2 (phospholipase A2, group IVE) …
PLA2G4E, a candidate gene for resilience in Alzheimers disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A. Pérez-González M, et al. Prog Neurobiol. 2020 Aug;191:101818. doi: 10.1016/j.pneurobio.2020.101818. Epub 2020 May 5. Prog Neurobiol. 2020. PMID: 32380223
These PLA2G4E overexpressing APP/PS1 mice developed significantly more dendritic spines than sham-injected mice, coinciding with the cognitive improvement observed. Hence, these results support the idea that a loss of PLA2G4E might play a key role in the onset of de …
These PLA2G4E overexpressing APP/PS1 mice developed significantly more dendritic spines than sham-injected mice, coinciding with the …
Assay of NAT Activity.
Uyama T, Ueda N. Uyama T, et al. Methods Mol Biol. 2023;2576:213-224. doi: 10.1007/978-1-0716-2728-0_17. Methods Mol Biol. 2023. PMID: 36152189
Later, this enzyme was identified as cPLA(2)epsilon (also referred to as PLA2G4E). On the other hand, members of the phospholipase A/acyltransferase (PLAAT) family (also known as HRAS-like suppressor family) show Ca(2+)-independent NAT activity. ...
Later, this enzyme was identified as cPLA(2)epsilon (also referred to as PLA2G4E). On the other hand, members of the phospholipase A/ …
Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder.
Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S. Morimoto Y, et al. Transl Psychiatry. 2018 Feb 2;8(1):41. doi: 10.1038/s41398-017-0088-0. Transl Psychiatry. 2018. PMID: 29391400 Free PMC article.
Likewise, in a German case-control study (96 sporadic PD patients and 96 controls), PLA2G4E showed the lowest p value but again did not reach the significance threshold. ...Nonetheless, our results still leave open the possibility that rare protein-altering variants in …
Likewise, in a German case-control study (96 sporadic PD patients and 96 controls), PLA2G4E showed the lowest p value but again did n …
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia.
Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta KI, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N. Rahman SMK, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Dec;1867(12):159222. doi: 10.1016/j.bbalip.2022.159222. Epub 2022 Aug 19. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35988872
NAPEs can be formed through N-acylation of phosphatidylethanolamine by cytosolic phospholipase A(2)epsilon (cPLA(2)epsilon, also known as PLA2G4E) or members of the phospholipase A and acyltransferase (PLAAT) family. ...Here, we investigated a possible role of cPLA(2)epsil …
NAPEs can be formed through N-acylation of phosphatidylethanolamine by cytosolic phospholipase A(2)epsilon (cPLA(2)epsilon, also known as …
Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.
Liang L, Takamiya R, Miki Y, Heike K, Taketomi Y, Sugimoto N, Yamaguchi M, Shitara H, Nishito Y, Kobayashi T, Hirabayashi T, Murakami M. Liang L, et al. FASEB J. 2022 May;36(5):e22301. doi: 10.1096/fj.202101958R. FASEB J. 2022. PMID: 35478358
Herein, we show that group IVE cytosolic phospholipase A(2) (cPLA(2) epsilon/PLA2G4E) plays a counterregulatory role against psoriatic inflammation by producing the anti-inflammatory lipid N-acylethanolamine (NAE). ...Stimulation of cultured human keratinocytes with psoria …
Herein, we show that group IVE cytosolic phospholipase A(2) (cPLA(2) epsilon/PLA2G4E) plays a counterregulatory role against psoriati …
A BRAF mutation-associated gene risk model for predicting the prognosis of melanoma.
Huang X, Gou W, Song Q, Huang Y, Wen C, Bo X, Jiang X, Feng J, Gao H. Huang X, et al. Heliyon. 2023 May 2;9(5):e15939. doi: 10.1016/j.heliyon.2023.e15939. eCollection 2023 May. Heliyon. 2023. PMID: 37205993 Free PMC article.
We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, and ST3GAL5) and assessed its prediction accuracy using ROC curve analysis. ...
We then developed a prognostic signature based on 7 BRAF-associated genes (PLA2G2D, FUT8, PLA2G4E, PLA2G5, PLA2G1B, B3GNT2, and ST3GA …
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris.
Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, Wasikowski R, Smith KM, Honore P, Scott VE, Maverakis E, Kahlenberg JM, Wang G, Ward NL, Harms PW, Gudjonsson JE. Shao S, et al. JCI Insight. 2021 Oct 22;6(20):e151911. doi: 10.1172/jci.insight.151911. JCI Insight. 2021. PMID: 34491907 Free PMC article.
The major common pathway shared between psoriasis and PRP involves the phospholipases PLA2G2F, PLA2G4D, and PLA2G4E, which were found to be primarily expressed in the epidermis. ...
The major common pathway shared between psoriasis and PRP involves the phospholipases PLA2G2F, PLA2G4D, and PLA2G4E, which were found …
Small-cell variant renal oncocytoma: Case report on its clinicopathological and genetic characteristics and literature review.
Li K, Wang C, Xiong X, Ma H, Qi Y, Hu W, Xiao S, Zhou X, Pang L, Zou H. Li K, et al. Gene. 2020 Mar 10;730:144266. doi: 10.1016/j.gene.2019.144266. Epub 2019 Dec 3. Gene. 2020. PMID: 31809837 Review.
Findings from the molecular genetic analysis of our case suggests that metabolic pathway-related genes (PIK3R5, PI3KCB, PLA2G4E, PLA2G2A, PLA2G6, PLCB4, PLCG2) may be exploited as potential targets for diagnosis and treatment when necessary. ...
Findings from the molecular genetic analysis of our case suggests that metabolic pathway-related genes (PIK3R5, PI3KCB, PLA2G4E, PLA2 …
Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma.
Wang Y, Wang L, Li X, Qu X, Han N, Ruan M, Zhang C. Wang Y, et al. Arch Oral Biol. 2021 Jun;126:105116. doi: 10.1016/j.archoralbio.2021.105116. Epub 2021 Mar 31. Arch Oral Biol. 2021. PMID: 33831734
RESULTS: For DEGs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed potential lymphatic metastasis-related biological processes and signaling pathways. Eight hub genes - ALOXE3, CSTA, PLA2G4E, PPL, SPRR1A, SPRR2A, SPRR2D, and SPRR2E, …
RESULTS: For DEGs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed potential lymphatic metastasis-re …
29 results