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PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases.
Barlow-Busch I, Shaw AL, Burke JE. Barlow-Busch I, et al. Curr Opin Cell Biol. 2023 Aug;83:102207. doi: 10.1016/j.ceb.2023.102207. Epub 2023 Jul 14. Curr Opin Cell Biol. 2023. PMID: 37453227 Review.
This review will present a summary of recent discoveries on the roles of two phosphoinositide kinases (PI4KA and PIKfyve), which have emerged as targets for therapeutic intervention. Phosphatidylinositol 4-kinase alpha (PI4KA) generates PI4P at the plasma membrane a …
This review will present a summary of recent discoveries on the roles of two phosphoinositide kinases (PI4KA and PIKfyve), which have …
Biallelic PI4KA variants cause neurological, intestinal and immunological disease.
Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla MP, Chioza BA, Wenger O, Scott E, Cross HE, Crawford J, Warshawsky I, Keisling M, Agamanolis D, Ward Melver C, Cox H, Elawad M, Marton T, Wakeling MN, Holzinger D, Tippelt S, Munteanu M, Valcheva D, Deal C, Van Meerbeke S, Walsh Vockley C, Butte MJ, Acar U, van der Knaap MS, Korenke GC, Kotzaeridou U, Balla T, Simons C, Uhlig HH, Crosby AH, De Camilli P, Wolf NI, Baple EL. Salter CG, et al. Brain. 2021 Dec 31;144(12):3597-3610. doi: 10.1093/brain/awab313. Brain. 2021. PMID: 34415310 Free PMC article.
Phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha/PI4KA/OMIM:600286) is a lipid kinase generating phosphatidylinositol 4-phosphate (PI4P), a membrane phospholipid with critical roles in the physiology of multiple cell types. ...Together, these data define PI4KA g …
Phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha/PI4KA/OMIM:600286) is a lipid kinase generating phosphatidylinositol 4-phosphate …
Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease.
Suresh S, Burke JE. Suresh S, et al. Adv Biol Regul. 2023 Dec;90:100996. doi: 10.1016/j.jbior.2023.100996. Epub 2023 Nov 10. Adv Biol Regul. 2023. PMID: 37979461 Review.
In all eukaryotes PI4KA is recruited to the plasma membrane by the protein EFR3, which does not directly bind PI4KA, but instead binds to the TTC7/ypp1 regulatory partner. Misregulation in PI4KA or its regulatory partners is involved in myriad human diseases, …
In all eukaryotes PI4KA is recruited to the plasma membrane by the protein EFR3, which does not directly bind PI4KA, but inste …
Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth.
Govindarajan B, Sbrissa D, Pressprich M, Kim S, Rishi AK, Vaishampayan U, Cher ML, Chinni SR. Govindarajan B, et al. Sci Rep. 2023 Nov 23;13(1):20634. doi: 10.1038/s41598-023-47633-4. Sci Rep. 2023. PMID: 37996444 Free PMC article.
The chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer (PCa). Previously, we established that CXCR4 interacts with phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha encoded by PI4KA) thr …
The chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer ( …
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Adhikari H, Kattan WE, Kumar S, Zhou P, Hancock JF, Counter CM. Adhikari H, et al. Nat Commun. 2021 Sep 9;12(1):5248. doi: 10.1038/s41467-021-25523-5. Nat Commun. 2021. PMID: 34504076 Free PMC article.
Here we identify EFR3A, an adapter protein for the phosphatidylinositol kinase PI4KA, to preferentially bind oncogenic KRAS. Disrupting EFR3A or PI4KA reduces phosphatidylinositol-4-phosphate, phosphatidylserine, and KRAS levels at the plasma membrane, as well as on …
Here we identify EFR3A, an adapter protein for the phosphatidylinositol kinase PI4KA, to preferentially bind oncogenic KRAS. Disrupti …
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.
Zhang Y, Ji S, Zhang X, Lu M, Hu Y, Han Y, Shui G, Lam SM, Zou X. Zhang Y, et al. Int J Biol Sci. 2022 Jul 27;18(13):4963-4983. doi: 10.7150/ijbs.70007. eCollection 2022. Int J Biol Sci. 2022. PMID: 35982909 Free PMC article.
Pancreatic cancer (PC) is a devastating solid malignancy with a dismal prognosis. ...In PC cells, human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling. Sp (specific protein)-1 and Sp3 transcription factors also act a …
Pancreatic cancer (PC) is a devastating solid malignancy with a dismal prognosis. ...In PC cells, human CPTP promotes growth and meta …
PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells.
Roy A, Chakraborty AR, Nomanbhoy T, DePamphilis ML. Roy A, et al. Autophagy. 2023 Sep;19(9):2464-2484. doi: 10.1080/15548627.2023.2182594. Epub 2023 Mar 22. Autophagy. 2023. PMID: 36803256 Free PMC article.
Although PIKFYVE phosphoinositide kinase inhibitors can selectively eliminate PIKFYVE-dependent human cancer cells in vitro and in vivo, the basis for this selectivity has remained elusive. ...Consequently, inhibition of PIP5K1C in WX8-resistant cells transformed them into …
Although PIKFYVE phosphoinositide kinase inhibitors can selectively eliminate PIKFYVE-dependent human cancer cells in vitro and in vi …
Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis.
Jiang X, Huang X, Zheng G, Jia G, Li Z, Ding X, Lei L, Yuan L, Xu S, Gao N. Jiang X, et al. Theranostics. 2022 Oct 3;12(16):6972-6988. doi: 10.7150/thno.76563. eCollection 2022. Theranostics. 2022. PMID: 36276647 Free PMC article.
Recent evidence has revealed that phosphatidylinositol 4 kinase-IIIalpha (PI4KA) plays a critical role in tumorigenesis. However, the molecular mechanisms of PI4KA-regulated chemoresistance and leukemogenesis remain largely unknown. ...We also identified cepharanthi …
Recent evidence has revealed that phosphatidylinositol 4 kinase-IIIalpha (PI4KA) plays a critical role in tumorigenesis. However, the …
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
McPhail JA, Burke JE. McPhail JA, et al. Adv Exp Med Biol. 2020;1274:203-222. doi: 10.1007/978-3-030-50621-6_9. Adv Exp Med Biol. 2020. PMID: 32894512 Review.
The class I phosphoinositide kinases which generate the critical lipid signal PIP(3) are hyperactivated in numerous human pathologies including cancer, overgrowth syndromes, and primary immunodeficiencies. The type III phosphatidylinositol 4-kinase beta isoform (PI4KB), wh …
The class I phosphoinositide kinases which generate the critical lipid signal PIP(3) are hyperactivated in numerous human pathologies includ …
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.
Ziyad S, Riordan JD, Cavanaugh AM, Su T, Hernandez GE, Hilfenhaus G, Morselli M, Huynh K, Wang K, Chen JN, Dupuy AJ, Iruela-Arispe ML. Ziyad S, et al. Cell Rep. 2018 Jan 30;22(5):1211-1224. doi: 10.1016/j.celrep.2018.01.017. Cell Rep. 2018. PMID: 29386109 Free PMC article.
Here, we find that endothelium-specific transposon mutagenesis in mice promotes hematopoietic pathologies that are both myeloid and lymphoid in nature. Frequently mutated genes included previously recognized cancer drivers and additional candidates, such as Pi4ka, a …
Here, we find that endothelium-specific transposon mutagenesis in mice promotes hematopoietic pathologies that are both myeloid and lymphoid …
17 results