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Year Number of Results
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2008 2
2009 3
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2013 3
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71 results

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PDE4D binds and interacts with YAP to cooperatively promote HCC progression.
Ren H, Chen Y, Ao Z, Cheng Q, Yang X, Tao H, Zhao L, Shen A, Li P, Fu Q. Ren H, et al. Cancer Lett. 2022 Aug 10;541:215749. doi: 10.1016/j.canlet.2022.215749. Epub 2022 May 19. Cancer Lett. 2022. PMID: 35597479
PDE4D bound to yes-associated protein (YAP), and PDE4D expression positively correlated with YAP expression in HCC. ...In contrast, silencing PDE4D reduced YAP expression and HCC cell growth. Notably, forced expression of YAP promoted PDE4D and YAP tar …
PDE4D bound to yes-associated protein (YAP), and PDE4D expression positively correlated with YAP expression in HCC. ...In cont …
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL. Jeong MH, et al. JCI Insight. 2023 Jul 10;8(13):e158098. doi: 10.1172/jci.insight.158098. JCI Insight. 2023. PMID: 37427586 Free PMC article.
Here, we report that phosphodiesterase 4D (PDE4D) promotes pancreatic cancer tumor growth by increasing mTORC1 signaling. ...Moreover, pancreatic cancer exhibits an upregulation of PDE4D expression, and high PDE4D levels predict the poor overall …
Here, we report that phosphodiesterase 4D (PDE4D) promotes pancreatic cancer tumor growth by increasing mTORC1 signaling. ...M …
Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer.
Saatci O, Cetin M, Uner M, Tokat UM, Chatzistamou I, Ersan PG, Montaudon E, Akyol A, Aksoy S, Uner A, Marangoni E, Sajish M, Sahin O. Saatci O, et al. Nat Commun. 2023 Nov 2;14(1):6997. doi: 10.1038/s41467-023-42736-y. Nat Commun. 2023. PMID: 37914699 Free PMC article.
Mechanistically, SOC therapy downregulates phosphodiesterase 4D (PDE4D), a novel ER target gene in a feedforward loop with ER, resulting in increased cAMP, PKA-dependent phosphorylation of mitochondrial COXIV-I, ROS generation and DNA damage. However, during SOC resistance …
Mechanistically, SOC therapy downregulates phosphodiesterase 4D (PDE4D), a novel ER target gene in a feedforward loop with ER, result …
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.
Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hänze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R. Pullamsetti SS, et al. Oncogene. 2013 Feb 28;32(9):1121-34. doi: 10.1038/onc.2012.136. Epub 2012 Apr 23. Oncogene. 2013. PMID: 22525277
Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that cyclic nucleotide phosphodiesterases (PDEs) are relevant in various cancer pathologies. ...On the other hand, overexpression of PDE4A or PDE4D increased human lung …
Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that cyclic nucleotide phosphodiesterases (PDE …
Inhibition of TPL2 by interferon-alpha suppresses bladder cancer through activation of PDE4D.
Qiang Z, Zhou ZY, Peng T, Jiang PZ, Shi N, Njoya EM, Azimova B, Liu WL, Chen WH, Zhang GL, Wang F. Qiang Z, et al. J Exp Clin Cancer Res. 2018 Nov 27;37(1):288. doi: 10.1186/s13046-018-0971-4. J Exp Clin Cancer Res. 2018. PMID: 30482227 Free PMC article.
Tissue microarray chips were used to investigate the prognostic roles of PDE4D and tumor progression locus 2 (TPL2) in bladder cancer patients. ...Reduction of the intracellular cAMP level by PDE4D potentiated the antitumor effect of IFN-alpha against bladder …
Tissue microarray chips were used to investigate the prognostic roles of PDE4D and tumor progression locus 2 (TPL2) in bladder can …
Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases.
Böttcher R, Dulla K, van Strijp D, Dits N, Verhoef EI, Baillie GS, van Leenders GJ, Houslay MD, Jenster G, Hoffmann R. Böttcher R, et al. Oncotarget. 2016 Oct 25;7(43):70669-70684. doi: 10.18632/oncotarget.12204. Oncotarget. 2016. PMID: 27683107 Free PMC article.
Phosphodiesterase 4D7 was recently shown to be specifically over-expressed in localized prostate cancer, raising the question as to which regulatory mechanisms are involved and whether other isoforms of this gene family (PDE4D) are affected under the same conditions …
Phosphodiesterase 4D7 was recently shown to be specifically over-expressed in localized prostate cancer, raising the question as to w …
PDE4D/cAMP/IL-23 axis determines the immunotherapy efficacy of lung adenocarcinoma via activating the IL-9 autocrine loop of cytotoxic T lymphocytes.
Feng B, Pan B, Huang J, Du Y, Wang X, Wu J, Ma R, Shen B, Huang G, Feng J. Feng B, et al. Cancer Lett. 2023 Jul 1;565:216224. doi: 10.1016/j.canlet.2023.216224. Epub 2023 May 16. Cancer Lett. 2023. PMID: 37196909 Free article.
Although immunotherapy has changed the prognosis of many advanced malignancies including lung adenocarcinoma (LUAD), many patients are insensitive to the drugs, with the mechanisms yet to be elucidated. Herein, we identified PDE4D as an immunotherapy efficacy-related gene …
Although immunotherapy has changed the prognosis of many advanced malignancies including lung adenocarcinoma (LUAD), many patients are insen …
Overexpression of Pde4d in rat granulosa cells inhibits maturation and atresia of antral follicles to induce polycystic ovary.
Jin LY, Yu JE, Xu HY, Chen B, Yang Q, Liu Y, Guo MX, Zhou CL, Cheng Y, Pang HY, Wu HY, Sheng JZ, Huang HF. Jin LY, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166869. doi: 10.1016/j.bbadis.2023.166869. Epub 2023 Sep 4. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37673361
The Pde4d was overexpressed in rats via intrabursal infection with recombinant lentivirus to see the effect of Pde4d on ovarian morphology. ...CONCLUSION: Upregulation of Pde4d may contribute to polycystic ovary syndrome by impeding follicle maturation and pr …
The Pde4d was overexpressed in rats via intrabursal infection with recombinant lentivirus to see the effect of Pde4d on ovaria …
The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review.
Wang G, Ge L, Liu T, Zheng Z, Chen L. Wang G, et al. Phytomedicine. 2023 Feb;110:154647. doi: 10.1016/j.phymed.2023.154647. Epub 2023 Jan 2. Phytomedicine. 2023. PMID: 36628833 Review.
ATG possesses remarkable therapeutic potential against a wide range of human diseases, such as cancers, immune disorders and chronical diseases. The molecular mechanisms behind the biological effects of ATG have been intensively studied. ...METHOD: SciFinder, Pubmed, Web o …
ATG possesses remarkable therapeutic potential against a wide range of human diseases, such as cancers, immune disorders and chronica …
Genetics of ischemic stroke: Indian perspective.
Kaul S, Munshi A. Kaul S, et al. Neurol India. 2012 Sep-Oct;60(5):498-503. doi: 10.4103/0028-3886.103195. Neurol India. 2012. PMID: 23135027 Free article. Review.
They may provide novel targets for preventive therapeutics. The most intensively investigated candidate gene is PDE4D. There are several positive replication studies of PDE4D gene with stroke. ...Most of the reports are from Andhra Pradesh, a province in south India …
They may provide novel targets for preventive therapeutics. The most intensively investigated candidate gene is PDE4D. There are seve …
71 results