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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 4
2001 6
2002 4
2003 1
2004 4
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2006 1
2007 1
2008 2
2009 2
2010 2
2011 4
2012 3
2013 6
2014 3
2015 3
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2017 3
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71 results

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Page 1
Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
Liu T, Zhao Y, Tang N, Feng R, Yang X, Lu N, Wen J, Li L. Liu T, et al. PLoS One. 2012;7(10):e46934. doi: 10.1371/journal.pone.0046934. Epub 2012 Oct 9. PLoS One. 2012. PMID: 23056534 Free PMC article.
We confirmed the effect of proSAAS, the protein encoded by Pcsk1n, on PC1/3 C-terminal cleavage and its activity by Pcsk1n RNAi in MIN6 cells. Furthermore, by luciferase-reporter analysis, chromatin immunoprecipitation, and electrophoretic mobility shift assay, we r …
We confirmed the effect of proSAAS, the protein encoded by Pcsk1n, on PC1/3 C-terminal cleavage and its activity by Pcsk1n RNA …
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, Chen S, Collins FS. Xue D, et al. Cell Metab. 2023 Nov 7;35(11):1897-1914.e11. doi: 10.1016/j.cmet.2023.09.013. Epub 2023 Oct 18. Cell Metab. 2023. PMID: 37858332 Free article.
Additionally, the integrative association analyses identified four genes (CP, RNASE1, PCSK1N, and GSTA2) associated with insulin production, and two genes (TAGLN3 and DHRS2) associated with beta cell sensitivity to lipotoxicity. ...
Additionally, the integrative association analyses identified four genes (CP, RNASE1, PCSK1N, and GSTA2) associated with insulin prod …
Single Nucleus Transcriptome Data from Alzheimer's Disease Mouse Models Yield New Insight into Pathophysiology.
Weller AE, Ferraro TN, Doyle GA, Reiner BC, Crist RC, Berrettini WH. Weller AE, et al. J Alzheimers Dis. 2022;90(3):1233-1247. doi: 10.3233/JAD-220391. J Alzheimers Dis. 2022. PMID: 36213995
RESULTS: We identified several DEGs in both neuronal and glial cell subtypes in comparisons of wild type (WT) versus 5XFAD and WT versus T2KO mice, including Ttr, Fth1, Pcsk1n, Malat1, Rpl37, Rtn1, Sepw1, Uba52, Mbp, Arl6ip5, Gm26917, Vwa1, and Pgrmc1. ...
RESULTS: We identified several DEGs in both neuronal and glial cell subtypes in comparisons of wild type (WT) versus 5XFAD and WT versus T2K …
Novel biomarkers predict prognosis and drug-induced neuroendocrine differentiation in patients with prostate cancer.
Lin J, Cai Y, Wang Z, Ma Y, Pan J, Liu Y, Zhao Z. Lin J, et al. Front Endocrinol (Lausanne). 2023 Jan 5;13:1005916. doi: 10.3389/fendo.2022.1005916. eCollection 2022. Front Endocrinol (Lausanne). 2023. PMID: 36686485 Free PMC article.
Secondly, a CRPC-NE diagnostic model of six genes (HMGN2, MLLT11, SOX4, PCSK1N, RGS16 and PTMA) has been established and verified, the area under the ROC curve (AUC) is as high as 0.952 (95% CI: 0.882-0.994). The mutation landscape shows that these six genes are rarely mut …
Secondly, a CRPC-NE diagnostic model of six genes (HMGN2, MLLT11, SOX4, PCSK1N, RGS16 and PTMA) has been established and verified, th …
Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach.
van Steenoven I, Koel-Simmelink MJA, Vergouw LJM, Tijms BM, Piersma SR, Pham TV, Bridel C, Ferri GL, Cocco C, Noli B, Worley PF, Xiao MF, Xu D, Oeckl P, Otto M, van der Flier WM, de Jong FJ, Jimenez CR, Lemstra AW, Teunissen CE. van Steenoven I, et al. Mol Neurodegener. 2020 Jun 18;15(1):36. doi: 10.1186/s13024-020-00388-2. Mol Neurodegener. 2020. PMID: 32552841 Free PMC article.
Independent cohort replication confirmed VGF, SCG2, NPTX2, NPTXR, PDYN and PCSK1N as candidate biomarkers for DLB. The downregulation of the candidate biomarkers was somewhat more pronounced in DLB in comparison with related neurodegenerative diseases. ...Moreover, we conf …
Independent cohort replication confirmed VGF, SCG2, NPTX2, NPTXR, PDYN and PCSK1N as candidate biomarkers for DLB. The downregulation …
Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid.
Ainiwan Y, Chen Y, Mao C, Peng J, Chen S, Wei S, Qi S, Pan J. Ainiwan Y, et al. J Neuroinflammation. 2022 May 7;19(1):108. doi: 10.1186/s12974-022-02470-6. J Neuroinflammation. 2022. PMID: 35525962 Free PMC article.
RESULTS: ACP cystic fluid caused growth retardation and an increased obesity index in mice, affected the expression of the Npy, Fgfr2, Rnpc3, Sst, and Pcsk1n genes that regulate growth and energy metabolism in hypothalamic neurons, and enhanced the cellular interaction of …
RESULTS: ACP cystic fluid caused growth retardation and an increased obesity index in mice, affected the expression of the Npy, Fgfr2, Rnpc3 …
GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice.
Ram A, Edwards T, McCarty A, Afrose L, McDermott MV, Bobeck EN. Ram A, et al. Front Pain Res (Lausanne). 2021 Sep 10;2:695396. doi: 10.3389/fpain.2021.695396. eCollection 2021. Front Pain Res (Lausanne). 2021. PMID: 35295419 Free PMC article.
Gene expression of GPR171 and that of its endogenous ligand BigLEN, encoded by the gene PCSK1N, were unaltered within the periaqueductal gray (PAG) in both male and female mice following inflammatory and neuropathic pain. ...
Gene expression of GPR171 and that of its endogenous ligand BigLEN, encoded by the gene PCSK1N, were unaltered within the periaqueduc …
Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation.
Wu W, Kong S, Wang B, Chen Y, Wang H. Wu W, et al. Cell Tissue Res. 2016 Feb;363(2):555-65. doi: 10.1007/s00441-015-2259-8. Epub 2015 Aug 23. Cell Tissue Res. 2016. PMID: 26298082
This tight regulation of the endogenous opioid system by PC1/3, Pcsk1n and MME has been further confirmed in physiologically related pseudopregnancy and delayed implantation mouse models. ...Thus, endogenous uterine opioid levels are primarily determined by the coordinated …
This tight regulation of the endogenous opioid system by PC1/3, Pcsk1n and MME has been further confirmed in physiologically related …
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Chong ACN, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhou T, Bonnycastle LL, Zhong A, Chen S, Collins FS. Xue D, et al. bioRxiv [Preprint]. 2023 May 8:2023.05.07.539774. doi: 10.1101/2023.05.07.539774. bioRxiv. 2023. PMID: 37214922 Free PMC article. Updated. Preprint.
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with insulin production, and two genes ( TAGLN3 and DHRS2 ) associated with sensitivity to lipotoxicity. ...
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with …
71 results