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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. Zhang Z, et al. Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21. Mol Cell. 2019. PMID: 30472188 Free article.
We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ. We also identified a yet-unknown SUMO-interacting motif (SIM) in YAP and TAZ required for their association with SUMOylated OTUB2. Importantly, EGF and oncogenic KRA …
We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ. We also identified a yet-unknown …
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis.
Yu S, Zang W, Qiu Y, Liao L, Zheng X. Yu S, et al. Oncogene. 2022 Jan;41(1):46-56. doi: 10.1038/s41388-021-02071-2. Epub 2021 Oct 20. Oncogene. 2022. PMID: 34671086
Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production. ...Furthermore, in vivo assays show that knockout of OTUB2 inhibits tumor growth in mice. Taken together, these findings reveal the critical role of OTUB2 …
Moreover, OTUB2 depletion reduces glucose consumption, lactate production, and cellular ATP production. ...Furthermore, in vivo assay …
Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1.
Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, Chen S, Rao Y, Lin C, Yang J, Liu P, Zhang J, Huang C, Xia N. Ren W, et al. Nat Commun. 2024 Jan 2;15(1):9. doi: 10.1038/s41467-023-44466-7. Nat Commun. 2024. PMID: 38167274 Free PMC article.
An inhibitor of OTUB2, interfering with its deubiquitinase activity without disrupting the OTUB2-PD-L1 interaction, successfully reduces PD-L1 expression in tumor cells and suppressed tumor growth. Together, these results reveal the roles of OTUB2 in PD-L1 re …
An inhibitor of OTUB2, interfering with its deubiquitinase activity without disrupting the OTUB2-PD-L1 interaction, successful …
Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis.
Wang J, Dong Y, Wei Z, Zhang Y, Wu N, Zhang C, Zhang Y, Zi R, Hao J, Liang H, Chen J. Wang J, et al. Exp Cell Res. 2023 Apr 1;425(1):113537. doi: 10.1016/j.yexcr.2023.113537. Epub 2023 Feb 27. Exp Cell Res. 2023. PMID: 36858343
Mechanistically, OTUB2 promotes CTNNB1 expression by interacting with the E3 ligase TRAF6. ...Therefore, advanced iCCA patients may benefit from drugs targeting OTUB2 and its pathway....
Mechanistically, OTUB2 promotes CTNNB1 expression by interacting with the E3 ligase TRAF6. ...Therefore, advanced iCCA patients may b …
OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis.
Chang W, Luo Q, Wu X, Nan Y, Zhao P, Zhang L, Luo A, Jiao W, Zhu Q, Fu Y, Liu Z. Chang W, et al. Cell Rep. 2022 Oct 25;41(4):111561. doi: 10.1016/j.celrep.2022.111561. Cell Rep. 2022. PMID: 36288705 Free article.
In mouse models, orally administered soybean-derived PS inhibits SCC initiation in cells with low OTUB2 expression and increases their sensitivity to chemotherapy. Our study indicates that the OTUB2/STAT1/CALML3/PS axis plays tumor-suppressive roles and shows the po …
In mouse models, orally administered soybean-derived PS inhibits SCC initiation in cells with low OTUB2 expression and increases thei …
The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function.
Li J, Zhang N, Li M, Hong T, Meng W, Ouyang T. Li J, et al. Front Cell Dev Biol. 2022 Mar 2;10:820781. doi: 10.3389/fcell.2022.820781. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35309903 Free PMC article. Review.
OTUB2 is likely to cause cancer and other malignant diseases while maintaining normal human development and physiological function. Therefore, it is of great value to comprehensively understand the regulatory mechanism of OTUB2 and regard it as a target for the trea …
OTUB2 is likely to cause cancer and other malignant diseases while maintaining normal human development and physiological function. T …
OTUB2 Regulates YAP1/TAZ to Promotes the Progression of Esophageal Squamous Cell Carcinoma.
Liu L, Cheng H, Ji M, Su L, Lu Z, Hu X, Guan Y, Xiao J, Ma L, Zhang W, Pu H. Liu L, et al. Biol Proced Online. 2022 Jul 18;24(1):10. doi: 10.1186/s12575-022-00169-9. Biol Proced Online. 2022. PMID: 35850645 Free PMC article.
METHODS: Bioinformatics analysis was used to analyze OTUB2 expression in esophageal carcinoma and interactions between OTUB2 and YAP1/TAZ. ...Immunofluorescence, western blotting, and qRT-PCR were used to evaluate OTUB2 in ESCC cell lines. Cell lines with the …
METHODS: Bioinformatics analysis was used to analyze OTUB2 expression in esophageal carcinoma and interactions between OTUB2 a …
OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation.
Hu G, Yang J, Zhang H, Huang Z, Yang H. Hu G, et al. Cell Mol Bioeng. 2022 Feb 1;15(3):281-292. doi: 10.1007/s12195-022-00720-4. eCollection 2022 Jun. Cell Mol Bioeng. 2022. PMID: 35611163 Free PMC article.
Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results. Using two bioinformatics tools, PJA1 was identified as a potential gene regulated by OTUB2. Mec …
Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OT …
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Ouyang S, Zeng Z, Liu Z, Zhang Z, Sun J, Wang X, Ma M, Ye X, Yu J, Kang W. Ouyang S, et al. Cell Death Discov. 2022 Feb 2;8(1):45. doi: 10.1038/s41420-022-00839-3. Cell Death Discov. 2022. PMID: 35110531 Free PMC article.
OTUB2 is a deubiquitinating enzyme that contributes to tumor progression. ...Furthermore, by activating the Akt signaling pathway, OTUB2 and KRT80 facilitated GC proliferation. In summary, OTUB2 regulates KRT80 stability via deubiquitination promoting prolife …
OTUB2 is a deubiquitinating enzyme that contributes to tumor progression. ...Furthermore, by activating the Akt signaling pathway, …
OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties.
Liu G, Guo W, Qin J, Lin Z. Liu G, et al. Front Oncol. 2021 Sep 27;11:711735. doi: 10.3389/fonc.2021.711735. eCollection 2021. Front Oncol. 2021. PMID: 34646768 Free PMC article. Retracted.
We found that OTUB2 was upregulated in GC samples (n=140) and cells. Moreover, the overall, first progression and post progression survival rates of GC patients with high OTUB2 expression showed a poorer prognosis than that in those patients with low OTUB2 ex …
We found that OTUB2 was upregulated in GC samples (n=140) and cells. Moreover, the overall, first progression and post progression su …
48 results