-Oh no! hiPSCs misplace their 5hmCs

William E Lowry

doi:10.1016/j.stem.2013.06.007

-Oh no! hiPSCs misplace their 5hmCs

Cell Stem Cell. 2013 Jul 3;13(1):10-1. doi: 10.1016/j.stem.2013.06.007.

Author

William E Lowry¹

Affiliation

¹ Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA. blowry@ucla.edu

Abstract

hiPSCs and hESCs are thought to display subtle genetic and epigenetic variability. Recently in Nature Cell Biology, Wang et al. (2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs.

Publication types

Comment

MeSH terms

5-Methylcytosine / metabolism*
Cytosine / analogs & derivatives*
DNA-Binding Proteins / metabolism*
Humans
Induced Pluripotent Stem Cells / metabolism*
Proto-Oncogene Proteins / metabolism*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
5-Methylcytosine
Cytosine

Grants and funding

P01 GM099134/GM/NIGMS NIH HHS/United States