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920 results

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Page 1
Showing results for nm and ligand and mutation
Search for NNMT and ligand and mutation instead (1 results)
Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.
Henry NL, Somerfield MR, Dayao Z, Elias A, Kalinsky K, McShane LM, Moy B, Park BH, Shanahan KM, Sharma P, Shatsky R, Stringer-Reasor E, Telli M, Turner NC, DeMichele A. Henry NL, et al. J Clin Oncol. 2022 Sep 20;40(27):3205-3221. doi: 10.1200/JCO.22.01063. Epub 2022 Jun 27. J Clin Oncol. 2022. PMID: 35759724
If no mutation is found in ctDNA, testing in tumor tissue, if available, should be used. ...There are insufficient data to recommend routine testing of tumors for ESR1 mutations, for homologous recombination deficiency, or for TROP2 expression to guide MBC therapy s …
If no mutation is found in ctDNA, testing in tumor tissue, if available, should be used. ...There are insufficient data to recommend …
Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner.
Hußmann M, Schulte D, Weischer S, Carlantoni C, Nakajima H, Mochizuki N, Stainier DYR, Zobel T, Koch M, Schulte-Merker S. Hußmann M, et al. Elife. 2023 Apr 25;12:e82969. doi: 10.7554/eLife.82969. Elife. 2023. PMID: 37097004 Free PMC article.
Furthermore, we show genetic interaction between svep1 and tie1 in vivo, during early steps of lymphangiogenesis, and demonstrate that zebrafish as well as human Svep1/SVEP1 protein bind to the respective Tie1/TIE1 receptors in vitro. Since compound heterozygous mutations
Furthermore, we show genetic interaction between svep1 and tie1 in vivo, during early steps of lymphangiogenesis, and demonstrate that zebra …
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
Veldscholte J, Berrevoets CA, Ris-Stalpers C, Kuiper GG, Jenster G, Trapman J, Brinkmann AO, Mulder E. Veldscholte J, et al. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):665-9. doi: 10.1016/0960-0760(92)90401-4. J Steroid Biochem Mol Biol. 1992. PMID: 1562539 Review.
We have found that the androgen receptor in the LNCaP cells contains a single point mutation changing the sense of codon 868 (Thr to Ala) in the ligand binding domain. ...Androgens, progestagens, estrogens and several antiandrogens bind the mutated androgen r …
We have found that the androgen receptor in the LNCaP cells contains a single point mutation changing the sense of codon 868 (Thr to …
Radiosynthesis and characterization of [(18)F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism.
Lee SH, Denora N, Laquintana V, Mangiatordi GF, Lopedota A, Lopalco A, Cutrignelli A, Franco M, Delre P, Song IH, Kim HW, Kim SB, Park HS, Kim K, Lee SY, Youn H, Lee BC, Kim SE. Lee SH, et al. Eur J Nucl Med Mol Imaging. 2021 Dec;49(1):110-124. doi: 10.1007/s00259-021-05617-4. Epub 2021 Nov 16. Eur J Nucl Med Mol Imaging. 2021. PMID: 34783879 Free PMC article.
However, the clinical application of second-generation TSPO ligands as biomarkers is limited because of the presence of human rs6971 polymorphism that affects their binding. Here, we describe the ability of a new TSPO ligand, [(18)F]BS224, to identify abnormal TSPO …
However, the clinical application of second-generation TSPO ligands as biomarkers is limited because of the presence of human rs6971 …
Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands.
Canal CE, Cordova-Sintjago T, Liu Y, Kim MS, Morgan D, Booth RG. Canal CE, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):705-16. doi: 10.1124/jpet.113.208637. Epub 2013 Sep 30. J Pharmacol Exp Ther. 2013. PMID: 24080681 Free PMC article.
The (+)-6-OH-7-Cl-PAT enantiomer showed partial agonist effects at h5-HT2A wild-type (WT) and m5-HT2A A5.46S point-mutated receptors but did not activate m5-HT2A WT and h5-HT2A S5.46A point-mutated receptors, or h5-HT2B, h5-HT2C, and m5-HT2C receptors; (-)-6-OH-7-Cl …
The (+)-6-OH-7-Cl-PAT enantiomer showed partial agonist effects at h5-HT2A wild-type (WT) and m5-HT2A A5.46S point-mutated receptors …
Automating crystallographic structure solution and refinement of protein-ligand complexes.
Echols N, Moriarty NW, Klei HE, Afonine PV, Bunkóczi G, Headd JJ, McCoy AJ, Oeffner RD, Read RJ, Terwilliger TC, Adams PD. Echols N, et al. Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):144-54. doi: 10.1107/S139900471302748X. Epub 2013 Dec 25. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24419387 Free PMC article.
High-throughput drug-discovery and mechanistic studies often require the determination of multiple related crystal structures that only differ in the bound ligands, point mutations in the protein sequence and minor conformational changes. ...To accelerate this proce …
High-throughput drug-discovery and mechanistic studies often require the determination of multiple related crystal structures that only diff …
Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
Bhunia SS, Roy KK, Saxena AK. Bhunia SS, et al. J Chem Inf Model. 2011 Aug 22;51(8):1966-85. doi: 10.1021/ci200185q. Epub 2011 Aug 1. J Chem Inf Model. 2011. PMID: 21761917
The role of residue at 99th position of FXa and thrombin toward governing protease selectivity was further substantiated using molecular dynamics simulations on the wild-type and mutated Y99L FXa bound to thrombin-selective inhibitor 2. Furthermore, predictive CoMFA (FXa q …
The role of residue at 99th position of FXa and thrombin toward governing protease selectivity was further substantiated using molecular dyn …
Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis.
Zylberg J, Ecke D, Fischer B, Reiser G. Zylberg J, et al. Biochem J. 2007 Jul 15;405(2):277-86. doi: 10.1042/BJ20061728. Biochem J. 2007. PMID: 17338680 Free PMC article.
We computed an hP2Y11-R (human P2Y11) homology model with two templates, bovine-rhodopsin (2.6 A resolution; 1 A=0.1 nm) and a hP2Y1-ATP complex model. The hP2Y11-R model was refined using molecular dynamics calculations and validated by virtual screening methods, with an …
We computed an hP2Y11-R (human P2Y11) homology model with two templates, bovine-rhodopsin (2.6 A resolution; 1 A=0.1 nm) and a hP2Y1- …
Tyrosine B10 and heme-ligand interactions of Lucina pectinata hemoglobin II: control of heme reactivity.
Pietri R, Granell L, Cruz A, De Jesús W, Lewis A, Leon R, Cadilla CL, Garriga JL. Pietri R, et al. Biochim Biophys Acta. 2005 Mar 14;1747(2):195-203. doi: 10.1016/j.bbapap.2004.11.005. Epub 2004 Dec 19. Biochim Biophys Acta. 2005. PMID: 15698954
The pH titration data at neutral conditions showed visible bands at 486, 541, 577 and 605 nm for both proteins. This suggests the possible existence of a conformational equilibrium between an open and closed configuration due to the interactions of the TyrB10, ligand
The pH titration data at neutral conditions showed visible bands at 486, 541, 577 and 605 nm for both proteins. This suggests the pos …
Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding.
Stergiou C, Zisimopoulou P, Tzartos SJ. Stergiou C, et al. J Biol Chem. 2011 Mar 18;286(11):8884-92. doi: 10.1074/jbc.M110.171645. Epub 2011 Jan 20. J Biol Chem. 2011. PMID: 21252231 Free PMC article.
The wild-type ECDs and their mutants containing the more hydrophilic Cys-loop from the snail acetylcholine-binding protein (individually expressed or coexpressed) did not demonstrate any specific interaction with ligands. We then linked the mutated ECDs with the 24- …
The wild-type ECDs and their mutants containing the more hydrophilic Cys-loop from the snail acetylcholine-binding protein (individually exp …
920 results