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Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations.
Am J Surg Pathol. 2021 Oct 1;45(10):1382-1390. doi: 10.1097/PAS.0000000000001727.
Am J Surg Pathol. 2021.
PMID: 34232601
Free PMC article.
RS-L cells showed both strong Jagged-1 and Notch1 cytoplasmic immunostaining. Androgen-regulated NKX3.1 nuclear immunostaining was present in a subset of large intralobular cells in all cases. Double immunostaining showed coexpression of NKX3.1 and CD3 …
RS-L cells showed both strong Jagged-1 and Notch1 cytoplasmic immunostaining. Androgen-regulated NKX3.1 nuclear immunostaining …
Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.
Ha S, Iqbal NJ, Mita P, Ruoff R, Gerald WL, Lepor H, Taneja SS, Lee P, Melamed J, Garabedian MJ, Logan SK.
Ha S, et al.
Oncogene. 2013 Aug 22;32(34):3992-4000. doi: 10.1038/onc.2012.412. Epub 2012 Sep 17.
Oncogene. 2013.
PMID: 22986532
Free PMC article.
In vitro kinase assays confirmed that PIM1 can phosphorylate AR S213 in a ligand-independent manner and cell type-specific phosphorylation was observed in prostate cancer cell lines. ...An examination of AR-mediated transcription showed that reporter gene activity was redu …
In vitro kinase assays confirmed that PIM1 can phosphorylate AR S213 in a ligand-independent manner and cell type-specific phosphoryl …
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Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.
Yu X, Wang Y, Jiang M, Bierie B, Roy-Burman P, Shen MM, Taketo MM, Wills M, Matusik RJ.
Yu X, et al.
Prostate. 2009 Feb 15;69(3):249-62. doi: 10.1002/pros.20877.
Prostate. 2009.
PMID: 18991257
Free PMC article.
BACKGROUND: The role of Wnt/beta-Catenin signaling in embryogenesis and carcinogenesis has been extensively studied in organs such as colon, lung and pancreas, but little is known about Wnt/beta-Catenin signaling in the prostate. Although stabilizing mutations in APC and b …
BACKGROUND: The role of Wnt/beta-Catenin signaling in embryogenesis and carcinogenesis has been extensively studied in organs such as colon, …
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