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Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation.
Parmar G, Fong-McMaster C, Pileggi CA, Patten DA, Cuillerier A, Myers S, Wang Y, Hekimi S, Cuperlovic-Culf M, Harper ME. Parmar G, et al. J Biol Chem. 2024 Feb;300(2):105626. doi: 10.1016/j.jbc.2024.105626. Epub 2024 Jan 9. J Biol Chem. 2024. PMID: 38211818 Free PMC article.
The mechanisms underlying the formation of the I(1)III(2)IV(1) "respirasome" SC are also not fully understood, further limiting insights into these processes in physiology and diseases, including neurodegeneration and metabolic syndromes. NDUFB4 is a complex I accessory su …
The mechanisms underlying the formation of the I(1)III(2)IV(1) "respirasome" SC are also not fully understood, further limiting insights int …
Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study.
Li J, Yao YX, Yao PS. Li J, et al. Heart Lung Circ. 2023 Dec;32(12):1434-1442. doi: 10.1016/j.hlc.2023.09.003. Epub 2023 Dec 1. Heart Lung Circ. 2023. PMID: 38042639 Free article.
SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% CI 0.81-0.91; p=1.06e-06) and 0.96 (95% CI 0.94-0.98; p=9.39e-05), respectively. NDUFB4, ETHE1, POFUT2, TRIL, ADAM23, GXYLT1, OXT, T …
SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% …
Relationship between DNA methylation changes and skeletal muscle mass.
Gim JA, Lee SY, Kim SC, Baek KW, Seo SH, Yoo JI. Gim JA, et al. BMC Genom Data. 2023 Aug 31;24(1):48. doi: 10.1186/s12863-023-01152-3. BMC Genom Data. 2023. PMID: 37653517 Free PMC article.
The present study suggested that GAB2 and JPH3 in MMI1 method, HLA-DQB1 and TBCD in MMI2 method, GAB2, NDUFB4 and ISPD in MMI3 method are potential genes that can have an impact on muscle mass. ...
The present study suggested that GAB2 and JPH3 in MMI1 method, HLA-DQB1 and TBCD in MMI2 method, GAB2, NDUFB4 and ISPD in MMI3 method …
Proteomics reveals mitochondrial dysfunction and energy metabolism disturbance of intestine in a nonhuman primate model of depression.
Chen X, Liu Y, Pu J, Gui S, Wang D, Zhong X, Chen W, Tao W, Chen Y, Chen X, Xie P. Chen X, et al. J Affect Disord. 2023 Jul 15;333:562-570. doi: 10.1016/j.jad.2023.04.031. Epub 2023 Apr 18. J Affect Disord. 2023. PMID: 37080496 Free article.
The key DEPs were significantly associated with glycerophospholipid metabolism and imbalances of gut microbe. We confirmed that key molecules (NDUFB4, UQCR10, PISD) were significantly inhibited, which may disturb the energy transformation of the electron respiratory chain …
The key DEPs were significantly associated with glycerophospholipid metabolism and imbalances of gut microbe. We confirmed that key molecule …
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
Bennett NK, Lee M, Orr AL, Nakamura K. Bennett NK, et al. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2307904121. doi: 10.1073/pnas.2307904121. Epub 2024 Jan 11. Proc Natl Acad Sci U S A. 2024. PMID: 38207075 Free PMC article.
In addition, knockdown of a subset of complex I subunits-including NDUFA8, NDUFB4, and NDUFS8-decreased complex I activity, mitochondria-derived ATP, and supercomplex level, but knockdown of these genes had differential effects on ROS. ...
In addition, knockdown of a subset of complex I subunits-including NDUFA8, NDUFB4, and NDUFS8-decreased complex I activity, mitochond …
Selection and validation of reference genes for RT-qPCR in adipose and longissimus dorsi muscle tissues of buffalo.
Feng X, Cao X, Zhu R, Huang J. Feng X, et al. Anim Biotechnol. 2022 Jun;33(3):526-535. doi: 10.1080/10495398.2020.1811715. Epub 2020 Aug 31. Anim Biotechnol. 2022. PMID: 32862779
RNA sequencing data were firstly analyzed to obtain 10 candidate genes (FKBP1A, C25H16orf72, PNRC2, IQGAP1, ATP5PD, RPL6, NDUFB4, TRA2A, CAPRIN1, and METAP2) that with high and stable expression across adipose tissues. ...
RNA sequencing data were firstly analyzed to obtain 10 candidate genes (FKBP1A, C25H16orf72, PNRC2, IQGAP1, ATP5PD, RPL6, NDUFB4, TRA …
Screening of the differentially expressed proteins in malignant transformation of BEAS-2B cells induced by coal tar pitch extract.
Chai Y, Ji P, Effah CY, Duan S, Feng F, Wu Y. Chai Y, et al. Toxicol Res (Camb). 2023 Mar 13;12(2):270-281. doi: 10.1093/toxres/tfad015. eCollection 2023 Apr. Toxicol Res (Camb). 2023. PMID: 37125331 Free PMC article.
As a result, 6 hub proteins were screened by protein-protein interaction network analysis. The expression levels of COX7A2, COX7C, MT-CO2, NDUFB4, and NDUFB7 were up-regulated as well as the expression of RPS29 protein was down-regulated. ...As a result, this study suggest …
As a result, 6 hub proteins were screened by protein-protein interaction network analysis. The expression levels of COX7A2, COX7C, MT-CO2, …
Identification of Prognostic Dosage-Sensitive Genes in Colorectal Cancer Based on Multi-Omics.
Chang Z, Miao X, Zhao W. Chang Z, et al. Front Genet. 2020 Jan 9;10:1310. doi: 10.3389/fgene.2019.01310. eCollection 2019. Front Genet. 2020. PMID: 31998369 Free PMC article.
The differential co-expression network was built to discover their function in CRC. A total of six amplified genes (NDUFB4, WDR5B, IQCB1, KPNA1, GTF2E1, and SEC22A) were found to be associated with poor prognosis. ...In the differential co-expression network, these six gen …
The differential co-expression network was built to discover their function in CRC. A total of six amplified genes (NDUFB4, WDR5B, IQ …
Structure of Mammalian Respiratory Supercomplex I1III2IV1.
Wu M, Gu J, Guo R, Huang Y, Yang M. Wu M, et al. Cell. 2016 Dec 1;167(6):1598-1609.e10. doi: 10.1016/j.cell.2016.11.012. Cell. 2016. PMID: 27912063 Free article.
Several accessory or supernumerary subunits of CI, such as NDUFA11, NDUFB4, NDUFB8, and NDUFB9, directly contribute to the oligomerization of CI, CIII, and CIV. ...
Several accessory or supernumerary subunits of CI, such as NDUFA11, NDUFB4, NDUFB8, and NDUFB9, directly contribute to the oligomeriz …
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
Bennett NK, Lee M, Orr AL, Nakamura K. Bennett NK, et al. bioRxiv [Preprint]. 2023 Oct 18:2023.10.14.562276. doi: 10.1101/2023.10.14.562276. bioRxiv. 2023. PMID: 37904938 Free PMC article. Updated. Preprint.
In addition, knockdown of a subset of complex I subunits-including NDUFA8, NDUFB4, and NDUFS8-decreased complex I activity, mitochondria-derived ATP and supercomplex level, but knockdown of these genes had differential effects on ROS. ...
In addition, knockdown of a subset of complex I subunits-including NDUFA8, NDUFB4, and NDUFS8-decreased complex I activity, mitochond …
22 results