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Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.
Onyango CO, Cheng Q, Munde EO, Raballah E, Anyona SB, McMahon BH, Lambert CG, Onyango PO, Schneider KA, Perkins DJ, Ouma C. Onyango CO, et al. BMC Genomics. 2023 Sep 13;24(1):542. doi: 10.1186/s12864-023-09565-1. BMC Genomics. 2023. PMID: 37704951 Free PMC article.
As such, we examined the impact of genetic variation in the gene encoding a primary NK cell receptor, natural cytotoxicity-triggering receptor 3 (NCR3), on the occurrence of malaria and SMA episodes over time. METHODS: Susceptibility to malaria, SMA, and all-cause mortalit …
As such, we examined the impact of genetic variation in the gene encoding a primary NK cell receptor, natural cytotoxicity-triggering recept …
Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.
Kinlein A, Janes ME, Kincer J, Almeida T, Matz H, Sui J, Criscitiello MF, Flajnik MF, Ohta Y. Kinlein A, et al. Immunogenetics. 2021 Aug;73(4):333-348. doi: 10.1007/s00251-021-01209-6. Epub 2021 Mar 19. Immunogenetics. 2021. PMID: 33742259 Free PMC article.
NCR3 has a special, non-rearranging VJ-type immunoglobulin superfamily (IgSF) domain that predates the emergence of the rearranging antigen receptors. Herein we show that NCR3 loci are linked to the shark major histocompatibility complex (MHC), proving NCR3's
NCR3 has a special, non-rearranging VJ-type immunoglobulin superfamily (IgSF) domain that predates the emergence of the rearranging a
NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients.
Thiam A, Baaklini S, Mbengue B, Nisar S, Diarra M, Marquet S, Fall MM, Sanka M, Thiam F, Diallo RN, Torres M, Dieye A, Rihet P. Thiam A, et al. PeerJ. 2018 Dec 3;6:e6048. doi: 10.7717/peerj.6048. eCollection 2018. PeerJ. 2018. PMID: 30533319 Free PMC article.
Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria. ...CONCLUSIONS: Our results suggest that NCR3 genetic variation …
Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) l …
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.
Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d'Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Rönnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X. Rusakiewicz S, et al. Sci Transl Med. 2013 Jul 24;5(195):195ra96. doi: 10.1126/scitranslmed.3005727. Sci Transl Med. 2013. PMID: 23884468 Free PMC article.
We performed a case-control study of genetic polymorphisms of the NCR3/NKp30 gene and found that rs11575837 (G>A) residing in the promoter was associated with reduced gene transcription and function as well as protection to pSS. We also demonstrated that circulating lev …
We performed a case-control study of genetic polymorphisms of the NCR3/NKp30 gene and found that rs11575837 (G>A) residing in the …
Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients.
Wang X, Huang L, Wen X, Li D, Yang G, Zheng J. Wang X, et al. In Vivo. 2024 Jan-Feb;38(1):174-183. doi: 10.21873/invivo.13423. In Vivo. 2024. PMID: 38148073 Free PMC article.
Therefore, in this study, we sought to explore the role of NCR, especially NCR3 splice variants, in the process of NK cell deficiency in RCC patients. ...CONCLUSION: Decreased expression of immunostimulatory NCR3 splice variants and the inhibitory cytokine microenvi …
Therefore, in this study, we sought to explore the role of NCR, especially NCR3 splice variants, in the process of NK cell deficiency …
Association analyses of NCR3 polymorphisms with P. falciparum mild malaria.
Delahaye NF, Barbier M, Fumoux F, Rihet P. Delahaye NF, et al. Microbes Infect. 2007 Feb;9(2):160-6. doi: 10.1016/j.micinf.2006.11.002. Epub 2006 Dec 5. Microbes Infect. 2007. PMID: 17208487 Free article.
In this study, we considered NCR3 as a candidate gene, and we genotyped ten NCR3 single nucleotide polymorphisms (SNPs). Here, we report evidence of an association between mild malaria and NCR3 -412G>C polymorphism located within the promoter. Population-b …
In this study, we considered NCR3 as a candidate gene, and we genotyped ten NCR3 single nucleotide polymorphisms (SNPs). Here, …
Deficient Natural Killer Cell NKp30-Mediated Function and Altered NCR3 Splice Variants in Hepatocellular Carcinoma.
Mantovani S, Oliviero B, Lombardi A, Varchetta S, Mele D, Sangiovanni A, Rossi G, Donadon M, Torzilli G, Soldani C, Porta C, Pedrazzoli P, Chiellino S, Santambrogio R, Opocher E, Maestri M, Bernuzzi S, Rossello A, Clément S, De Vito C, Rubbia-Brandt L, Negro F, Mondelli MU. Mantovani S, et al. Hepatology. 2019 Mar;69(3):1165-1179. doi: 10.1002/hep.30235. Epub 2019 Feb 14. Hepatology. 2019. PMID: 30153337 Free article.
The activating natural cytotoxicity receptor NKp30 is critical for natural killer (NK) cell function and tumor immune surveillance. The natural cytotoxicity receptor-3 (NCR3) gene is transcribed into several splice variants whose physiological relevance is still incomplete …
The activating natural cytotoxicity receptor NKp30 is critical for natural killer (NK) cell function and tumor immune surveillance. The natu …
LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.
Mulcahy H, O'Rourke KP, Adams C, Molloy MG, O'Gara F. Mulcahy H, et al. Immunogenetics. 2006 Jan;57(12):893-903. doi: 10.1007/s00251-005-0057-2. Epub 2005 Dec 17. Immunogenetics. 2006. PMID: 16362817
The LST1 gene undergoes extensive alternative splicing, giving rise to both membrane-bound (encoded by exon 3) and soluble isoforms. The NCR3 protein is involved in NK-mediated cytotoxicity and plays a role in NK/dendritic cell crosstalk. ...The expression of LST1, specifi …
The LST1 gene undergoes extensive alternative splicing, giving rise to both membrane-bound (encoded by exon 3) and soluble isoforms. The …
Draft Genome Sequence of Enterobacter ludwigii NCR3, a Heavy Metal-Resistant Rhizobacterium.
Egidi E, Wood JL, Aracic S, Kannan R, McDonald L, Bell CA, Fox EM, Liu W, Franks AE. Egidi E, et al. Genome Announc. 2016 Oct 6;4(5):e01076-16. doi: 10.1128/genomeA.01076-16. Genome Announc. 2016. PMID: 27795247 Free PMC article.
We report here the draft genome of Enterobacter ludwigii NCR3, a Gram-negative bacterium isolated from the Carpobrotus rossii (Haw.) ...
We report here the draft genome of Enterobacter ludwigii NCR3, a Gram-negative bacterium isolated from the Carpobrotus rossii (Haw.) …
299 results