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T-cell immunotherapy: looking forward.
Corrigan-Curay J, Kiem HP, Baltimore D, O'Reilly M, Brentjens RJ, Cooper L, Forman S, Gottschalk S, Greenberg P, Junghans R, Heslop H, Jensen M, Mackall C, June C, Press O, Powell D, Ribas A, Rosenberg S, Sadelain M, Till B, Patterson AP, Jambou RC, Rosenthal E, Gargiulo L, Montgomery M, Kohn DB. Corrigan-Curay J, et al. Mol Ther. 2014 Sep;22(9):1564-74. doi: 10.1038/mt.2014.148. Mol Ther. 2014. PMID: 25186558 Free PMC article. No abstract available.
Ex Vivo Radiolabeling and In Vivo PET Imaging of T Cells Expressing Nuclear Reporter Genes.
Moroz MA, Zanzonico P, Lee JT, Ponomarev V. Moroz MA, et al. Methods Mol Biol. 2018;1790:153-163. doi: 10.1007/978-1-4939-7860-1_12. Methods Mol Biol. 2018. PMID: 29858790 Free PMC article.
T cells expressing tumor-associated T cell receptors (TCRs) or engineered with chimeric antigen receptors (CARs) face multiple challenges, including possible influence of genetic engineering on T cell efficacy, inhibitory effects of the tumor microenvironment, tumor checkpoint pr …
T cells expressing tumor-associated T cell receptors (TCRs) or engineered with chimeric antigen receptors (CARs) face multiple challenges, i …