MUS81 promotes common fragile site expression.
Nat Cell Biol. 2013.
PMID: 23811685
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MUS81 promotes common fragile site expression.
Nat Cell Biol. 2013 Aug;15(8):1001-7. doi: 10.1038/ncb2773. Epub 2013 Jun 30.
Nat Cell Biol. 2013.
PMID: 23811685
Recent work has demonstrated that the so-called common fragile sites (CFSs) often impair the faithful disjunction of sister chromatids in mitosis. ...These data indicate that CFS breakage is an active, MUS81-EME1-dependent process, and not a result of …
Recent work has demonstrated that the so-called common fragile sites (CFSs) often impair the faithful disjunction of si …
Structure-specific endonucleases: guardians of fragile site stability.
Trends Cell Biol. 2014 May;24(5):321-7. doi: 10.1016/j.tcb.2013.11.007. Epub 2013 Dec 19.
Trends Cell Biol. 2014.
PMID: 24361091
Review.
Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci is associated with chromosomal rearrangements in cancers and is a feature of cells from patients with chromosomal instability syndromes. One …
Fragile sites are conserved loci predisposed to form breaks in metaphase chromosomes. The inherent instability of these loci i …
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.
Mol Cell. 2017.
PMID: 28575661
Free article.
The MUS81-EME1 endonuclease cleaves late replication intermediates at common fragile sites (CFSs) during early mitosis to trigger DNA-repair synthesis that ensures faithful chromosome segregation. ...Upon replication stress, RECQ5 associates wit …
The MUS81-EME1 endonuclease cleaves late replication intermediates at common fragile sites (CFSs) during early m …
Replication stress activates DNA repair synthesis in mitosis.
Nature. 2015 Dec 10;528(7581):286-90. doi: 10.1038/nature16139. Epub 2015 Dec 2.
Nature. 2015.
PMID: 26633632
The MUS81-EME1 structure-specific endonuclease promotes the appearance of chromosome gaps or breaks at CFSs following replicative stress. Here we show that entry of cells into mitotic prophase triggers the recruitment of MUS81 to CFSs. The nuclease act …
The MUS81-EME1 structure-specific endonuclease promotes the appearance of chromosome gaps or breaks at CFSs following r …
A blooming resolvase at chromosomal fragile sites.
Nat Cell Biol. 2013 Aug;15(8):883-5. doi: 10.1038/ncb2812.
Nat Cell Biol. 2013.
PMID: 23907189
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. ...Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex whic …
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular …
Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
Carcinogenesis. 2012 Sep;33(9):1655-63. doi: 10.1093/carcin/bgs206. Epub 2012 Jun 11.
Carcinogenesis. 2012.
PMID: 22689923
WRN is crucial for the recovery of stalled replication forks and possesses both helicase and exonuclease enzymatic activities of uncertain biological significance. Previous work revealed that WRN promotes formation of MUS81-dependent double strand breaks (DSBs) at H …
WRN is crucial for the recovery of stalled replication forks and possesses both helicase and exonuclease enzymatic activities of uncertain b …
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