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606 results

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Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma.
Guo W, Wang X, Lu B, Yu J, Xu M, Huang R, Cheng M, Yang M, Zhao W, Zou C. Guo W, et al. Cell Death Dis. 2023 Jul 17;14(7):439. doi: 10.1038/s41419-023-05966-y. Cell Death Dis. 2023. PMID: 37460542 Free PMC article.
The prevalence of transcriptional addiction in cancer cells emphasizes the biological significance and clinical relevance of super-enhancers. In this study, we found that Max-like protein X (MLX), a member of the Myc-MLX network, is driven by super-enhancers. Upregu …
The prevalence of transcriptional addiction in cancer cells emphasizes the biological significance and clinical relevance of super-enhancers …
MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies.
Nagarajan SR, Livingstone EJ, Monfeuga T, Lewis LC, Ali SHL, Chandran A, Dearlove DJ, Neville MJ, Chen L, Maroteau C, Ruby MA, Hodson L. Nagarajan SR, et al. Metabolism. 2023 Jul;144:155563. doi: 10.1016/j.metabol.2023.155563. Epub 2023 Apr 21. Metabolism. 2023. PMID: 37088121 Free PMC article.
As human data is lacking, the aim of the present work was to investigate the role of MLX in regulating lipid and glucose metabolism in primary human hepatocytes (PHH) and in healthy participants with and without MLX polymorphisms. METHODS: PHH were transfected with …
As human data is lacking, the aim of the present work was to investigate the role of MLX in regulating lipid and glucose metabolism i …
Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development.
Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, Yu FX. Yu A, et al. Oncogene. 2023 Oct;42(43):3182-3193. doi: 10.1038/s41388-023-02831-2. Epub 2023 Sep 9. Oncogene. 2023. PMID: 37684408
However, it is currently unclear whether the glucose-induced lipogenic program plays a role in the development of HCCs. Here, we show that MLX expression is elevated in HCC specimens and downregulation of MLX expression inhibits proliferation of HCC cells. In mice, …
However, it is currently unclear whether the glucose-induced lipogenic program plays a role in the development of HCCs. Here, we show that …
Glucose sensing by ChREBP/MondoA-Mlx transcription factors.
Havula E, Hietakangas V. Havula E, et al. Semin Cell Dev Biol. 2012 Aug;23(6):640-7. doi: 10.1016/j.semcdb.2012.02.007. Epub 2012 Mar 3. Semin Cell Dev Biol. 2012. PMID: 22406740 Review.
The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators of intracellular glucose sensing. ...Here we review the regulation, function and evolutionary conservation of the ChREBP/MondoA-Mlx
The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators …
Sugar sensing by ChREBP/Mondo-Mlx-new insight into downstream regulatory networks and integration of nutrient-derived signals.
Havula E, Hietakangas V. Havula E, et al. Curr Opin Cell Biol. 2018 Apr;51:89-96. doi: 10.1016/j.ceb.2017.12.007. Epub 2017 Dec 23. Curr Opin Cell Biol. 2018. PMID: 29278834 Review.
Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms an …
Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. …
The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism.
Billin AN, Ayer DE. Billin AN, et al. Curr Top Microbiol Immunol. 2006;302:255-78. doi: 10.1007/3-540-32952-8_10. Curr Top Microbiol Immunol. 2006. PMID: 16620032 Review.
Unlike the Myc/Max/Mad network, our understanding of this network is still in its infancy. At the center of this network is a Max-like protein called Mlx; hence we have called this network the Mlx network. Like Max, Mix interacts with transcriptional repressors and …
Unlike the Myc/Max/Mad network, our understanding of this network is still in its infancy. At the center of this network is a Max-like prote …
The Myc-Like Mlx Network Impacts Aging and Metabolism.
Wang H, Stevens T, Lu J, Roberts A, Land CV, Muzumdar R, Gong Z, Vockley J, Prochownik EV. Wang H, et al. bioRxiv [Preprint]. 2023 Nov 27:2023.11.26.568749. doi: 10.1101/2023.11.26.568749. bioRxiv. 2023. PMID: 38076995 Free PMC article. Preprint.
The "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that bod …
The "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the …
MLX Is a Transcriptional Repressor of the Mammalian Golgi Stress Response.
Taniguchi M, Sasaki-Osugi K, Oku M, Sawaguchi S, Tanakura S, Kawai Y, Wakabayashi S, Yoshida H. Taniguchi M, et al. Cell Struct Funct. 2016 Jul 30;41(2):93-104. doi: 10.1247/csf.16005. Epub 2016 Jun 2. Cell Struct Funct. 2016. PMID: 27251850 Free article.
When the capacity of the Golgi apparatus becomes insufficient (Golgi stress), transcription levels of Golgi-related genes encoding glycosylation enzymes, a Golgi structural protein, and components of vesicular transport are upregulated through a common cis-acting enhancer-the Gol …
When the capacity of the Golgi apparatus becomes insufficient (Golgi stress), transcription levels of Golgi-related genes encoding glycosyla …
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.
Diolaiti D, McFerrin L, Carroll PA, Eisenman RN. Diolaiti D, et al. Biochim Biophys Acta. 2015 May;1849(5):484-500. doi: 10.1016/j.bbagrm.2014.05.016. Epub 2014 May 22. Biochim Biophys Acta. 2015. PMID: 24857747 Free PMC article. Review.
Notably, MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein MLX. This network includes MXD1-4, MNT, MGA, MONDOA and MONDOB proteins. ...
Notably, MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein …
Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. Mattila J, et al. Cell Rep. 2015 Oct 13;13(2):350-64. doi: 10.1016/j.celrep.2015.08.081. Epub 2015 Oct 1. Cell Rep. 2015. PMID: 26440885 Free article.
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. ...Sugarbabe controls a subset of Mondo-Mlx-dependent processes, including de novo lipogenesis and fatty acid desaturation. ...
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. ...Sugarbabe controls a sub …
606 results