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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2003 1
2005 5
2006 2
2007 3
2008 4
2009 2
2010 2
2011 2
2012 1
2013 1
2014 1
2015 4
2016 2
2018 1
2020 1
2021 1
2022 1
2023 1
2024 0

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29 results

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Page 1
A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve.
Siguero-Álvarez M, Salguero-Jiménez A, Grego-Bessa J, de la Barrera J, MacGrogan D, Prados B, Sánchez-Sáez F, Piñeiro-Sabarís R, Felipe-Medina N, Torroja C, Gómez MJ, Sabater-Molina M, Escribá R, Richaud-Patin I, Iglesias-García O, Sbroggio M, Callejas S, O'Regan DP, McGurk KA, Dopazo A, Giovinazzo G, Ibañez B, Monserrat L, Pérez-Pomares JM, Sánchez-Cabo F, Pendas AM, Raya A, Gimeno-Blanes JR, de la Pompa JL. Siguero-Álvarez M, et al. Circulation. 2023 Jan 3;147(1):47-65. doi: 10.1161/CIRCULATIONAHA.121.058767. Epub 2022 Nov 3. Circulation. 2023. PMID: 36325906 Free article.
Here, we show that 2 structural cardiac diseases, left ventricular noncompaction (LVNC) and bicuspid aortic valve, can be caused by a set of inherited heterozygous gene mutations affecting the NOTCH ligand regulator MIB1 (MINDBOMB1) and cosegregating genes. M …
Here, we show that 2 structural cardiac diseases, left ventricular noncompaction (LVNC) and bicuspid aortic valve, can be caused by a set of …
MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease.
Li B, Yu L, Liu D, Yang X, Zheng Y, Gui Y, Wang H. Li B, et al. Clin Sci (Lond). 2018 Dec 5;132(23):2483-2491. doi: 10.1042/CS20180732. Print 2018 Dec 12. Clin Sci (Lond). 2018. PMID: 30322850 Free PMC article.
However, the function of MIB1 and its potential disease-causing mutations are poorly studied in human CHD. In this research, we identified four novel non-synonymous heterozygous rare mutations of MIB1 from 417 Han Chinese CHD patients. The following bi …
However, the function of MIB1 and its potential disease-causing mutations are poorly studied in human CHD. In this research, w …
Programmed death ligand 1 protein expression is positively correlated with the solid predominant subtype, high MIB-1 labeling index, and p53 expression and negatively correlated with epidermal growth factor receptor mutations in lung adenocarcinoma.
Yanagawa N, Shiono S, Endo M, Ogata SY, Yamada N, Sugimoto R, Osakabe M, Uesugi N, Sugai T. Yanagawa N, et al. Hum Pathol. 2021 Feb;108:12-21. doi: 10.1016/j.humpath.2020.10.014. Epub 2020 Nov 5. Hum Pathol. 2021. PMID: 33159965
Programmed death ligand 1 (PD-L1) protein expression is a proposed predictive biomarker of immunotherapy; thus, identification of the clinicopathological and molecular characteristics associated with PD-L1 expression is important and necessary. ...PD-L1 expression was more …
Programmed death ligand 1 (PD-L1) protein expression is a proposed predictive biomarker of immunotherapy; thus, identification of the …
Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.
MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, Luxán G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gómez MJ, Zhou B, Redondo JM, Jiménez-Borreguero LJ, de la Pompa JL. MacGrogan D, et al. Circ Res. 2016 May 13;118(10):1480-97. doi: 10.1161/CIRCRESAHA.115.308077. Epub 2016 Apr 7. Circ Res. 2016. PMID: 27056911
RATIONALE: The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial-mesenchymal transition, and NOTCH1 mutations cause bicuspid aortic valve; however, the temporal requirement for the various Notch ligands and receptors during valve …
RATIONALE: The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial-mesenchymal transition, and NOTCH1 …
Delta-like 1-Lysine613 regulates notch signaling.
Zhang L, Widau RC, Herring BP, Gallagher PJ. Zhang L, et al. Biochim Biophys Acta. 2011 Dec;1813(12):2036-43. doi: 10.1016/j.bbamcr.2011.08.019. Epub 2011 Oct 2. Biochim Biophys Acta. 2011. PMID: 21985982 Free PMC article.
Delta ligands are important for regulating Notch signaling through transcellular stimulation of Notch receptors. ...To identify possible roles for specific lysine residues in the cytoplasmic tail of the Notch ligand Dll1 a mutational and functional analysis w …
Delta ligands are important for regulating Notch signaling through transcellular stimulation of Notch receptors. ...To identify possi …
Control of Notch-ligand endocytosis by ligand-receptor interaction.
Hansson EM, Lanner F, Das D, Mutvei A, Marklund U, Ericson J, Farnebo F, Stumm G, Stenmark H, Andersson ER, Lendahl U. Hansson EM, et al. J Cell Sci. 2010 Sep 1;123(Pt 17):2931-42. doi: 10.1242/jcs.073239. J Cell Sci. 2010. PMID: 20720151
In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and ligand-receptor interaction remains poorly understood. ...In conclusion, the interaction-dead Jagged1(Ndr) …
In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endoc …
The Notch ligand E3 ligase, Mind Bomb1, regulates glutamate receptor localization in Drosophila.
Sturgeon M, Davis D, Albers A, Beatty D, Austin R, Ferguson M, Tounsel B, Liebl FL. Sturgeon M, et al. Mol Cell Neurosci. 2016 Jan;70:11-21. doi: 10.1016/j.mcn.2015.11.004. Epub 2015 Nov 17. Mol Cell Neurosci. 2016. PMID: 26596173 Free PMC article.
Mutations in mib1 and ubiquitous expression of Mib1 that lacks its ubiquitin ligase activity result in the loss of synaptic GluRIIA-containing receptors. ...While deficient Mib1 signaling leads to overgrowth of the NMJ, ubiquitous overexpression of …
Mutations in mib1 and ubiquitous expression of Mib1 that lacks its ubiquitin ligase activity result in the loss of syna …
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.
Luxán G, Casanova JC, Martínez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL. Luxán G, et al. Nat Med. 2013 Feb;19(2):193-201. doi: 10.1038/nm.3046. Epub 2013 Jan 13. Nat Med. 2013. PMID: 23314057
Functional studies in cells and zebrafish embryos and in silico modeling indicate that MIB1 functions as a dimer, which is disrupted by the human mutations. ...These results implicate NOTCH signaling in LVNC and indicate that MIB1 mutations arrest cham …
Functional studies in cells and zebrafish embryos and in silico modeling indicate that MIB1 functions as a dimer, which is disrupted …
The interplay between DSL proteins and ubiquitin ligases in Notch signaling.
Pitsouli C, Delidakis C. Pitsouli C, et al. Development. 2005 Sep;132(18):4041-50. doi: 10.1242/dev.01979. Epub 2005 Aug 10. Development. 2005. PMID: 16093323
Neuralized physically associates with Serrate and stimulates its endocytosis and signaling activity. We also characterize a mutation in mib1, a Drosophila homolog of mind bomb, another Delta-targeting ubiquitin ligase from zebrafish. Mib1 affects the signalin …
Neuralized physically associates with Serrate and stimulates its endocytosis and signaling activity. We also characterize a mutation …
Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.
Palardy G, Chitnis AB. Palardy G, et al. PLoS One. 2015 May 28;10(5):e0127864. doi: 10.1371/journal.pone.0127864. eCollection 2015. PLoS One. 2015. PMID: 26020642 Free PMC article.
We have identified a domain in the intracellular part of the zebrafish Notch ligand DeltaD that is essential for effective interactions with Mib1. We show that elimination of the Mind bomb1 Interaction Domain (MID) or mutation of specific conserved motifs in …
We have identified a domain in the intracellular part of the zebrafish Notch ligand DeltaD that is essential for effective interactio …
29 results