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Page 1
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation.
Yang X, Ma Y, Li Y, Dong Y, Yu LL, Wang H, Guo L, Wu C, Yu X, Liu X. Yang X, et al. DNA Repair (Amst). 2020 Oct;94:102899. doi: 10.1016/j.dnarep.2020.102899. Epub 2020 Jun 22. DNA Repair (Amst). 2020. PMID: 32683309 Free PMC article.
MacroD1 is an enzyme that hydrolyzes protein mono-ADP-ribosylation. However, the key catalytic residues of MacroD1 in these biochemical reactions remain elusive. Here, we present the crystal structure of MacroD1 in a complex with ADP-ribose (ADPR). ...
MacroD1 is an enzyme that hydrolyzes protein mono-ADP-ribosylation. However, the key catalytic residues of MacroD1 in these bi …
Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD(+)-SIRT3 pathway.
Liu YT, Qiu HL, Xia HX, Feng YZ, Deng JY, Yuan Y, Ke D, Zhou H, Che Y, Tang QZ. Liu YT, et al. Acta Pharmacol Sin. 2024 Mar 8. doi: 10.1038/s41401-024-01247-2. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 38459256
We showed that Macrod1 expression levels were significantly downregulated in cardiac tissue of DCM mice. ...Schematic illustration of macrod1 ameliorating diabetic cardiomyopathy oxidative stress via PARP1-NAD(+)-SIRT3 axis....
We showed that Macrod1 expression levels were significantly downregulated in cardiac tissue of DCM mice. ...Schematic illustration of …
Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
Crawford K, Oliver PL, Agnew T, Hunn BHM, Ahel I. Crawford K, et al. Cells. 2021 Feb 10;10(2):368. doi: 10.3390/cells10020368. Cells. 2021. PMID: 33578760 Free PMC article.
Therefore, here we analysed both Macrod1 and Macrod2 gene knockout (KO) mouse models in a battery of well-defined, spontaneous behavioural testing paradigms. Loss of Macrod1 resulted in a female-specific motor-coordination defect, whereas Macrod2 disruption was asso …
Therefore, here we analysed both Macrod1 and Macrod2 gene knockout (KO) mouse models in a battery of well-defined, spontaneous behavi …
MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria.
Agnew T, Munnur D, Crawford K, Palazzo L, Mikoč A, Ahel I. Agnew T, et al. Front Microbiol. 2018 Jan 23;9:20. doi: 10.3389/fmicb.2018.00020. eCollection 2018. Front Microbiol. 2018. PMID: 29410655 Free PMC article.
To date, the physiological functions and sub-cellular localization of MacroD1 are unclear. Previous studies have described nuclear and cytosolic functions of MacroD1. However, in this study we show that endogenous MacroD1 protein is highly enriched within mit …
To date, the physiological functions and sub-cellular localization of MacroD1 are unclear. Previous studies have described nuclear an …
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.
Feijs KLH, Cooper CDO, Žaja R. Feijs KLH, et al. Cancers (Basel). 2020 Mar 5;12(3):604. doi: 10.3390/cancers12030604. Cancers (Basel). 2020. PMID: 32151005 Free PMC article. Review.
MACROD1, MACROD2, and TARG1 have a 'macrodomain' harbouring the catalytic site, but no other domains have been identified. ...In this review, we critically assess the available literature on a role for the hydrolases in cancer and find that, currently, there is limited evi …
MACROD1, MACROD2, and TARG1 have a 'macrodomain' harbouring the catalytic site, but no other domains have been identified. ...In this …
Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome.
Žaja R, Aydin G, Lippok BE, Feederle R, Lüscher B, Feijs KLH. Žaja R, et al. Sci Rep. 2020 May 19;10(1):8286. doi: 10.1038/s41598-020-64623-y. Sci Rep. 2020. PMID: 32427867 Free PMC article.
Loss of MACROD1 or loss of TARG1 leads to disruption of mitochondrial or nucleolar morphology, respectively, hinting at their importance for these organelles. ...The cellular localisation of interactors supports the mitochondrial, nucleolar and stress granule localisation …
Loss of MACROD1 or loss of TARG1 leads to disruption of mitochondrial or nucleolar morphology, respectively, hinting at their importa …
Are PARPs promiscuous?
Feijs KLH, Žaja R. Feijs KLH, et al. Biosci Rep. 2022 May 27;42(5):BSR20212489. doi: 10.1042/BSR20212489. Biosci Rep. 2022. PMID: 35380161 Free PMC article. Review.
ADP-ribosylation on arginine and serine is reversed by ARH1 and ARH3 respectively, whereas macrodomain-containing MACROD1, MACROD2 and TARG1 reverse modification of acidic residues. ...
ADP-ribosylation on arginine and serine is reversed by ARH1 and ARH3 respectively, whereas macrodomain-containing MACROD1, MACROD2 an …
Mono-ADP-Ribosylhydrolase Assays.
Abplanalp J, Hopp AK, Hottiger MO. Abplanalp J, et al. Methods Mol Biol. 2018;1813:205-213. doi: 10.1007/978-1-4939-8588-3_13. Methods Mol Biol. 2018. PMID: 30097869
Reversible ADP-ribosylation of RNA.
Munnur D, Bartlett E, Mikolčević P, Kirby IT, Rack JGM, Mikoč A, Cohen MS, Ahel I. Munnur D, et al. Nucleic Acids Res. 2019 Jun 20;47(11):5658-5669. doi: 10.1093/nar/gkz305. Nucleic Acids Res. 2019. PMID: 31216043 Free PMC article.
We further reveal that ADP-ribosylation of RNA mediated by PARP10 and TRPT1 can be efficiently reversed by several cellular ADP-ribosylhydrolases (PARG, TARG1, MACROD1, MACROD2 and ARH3), as well as by MACROD-like hydrolases from VEEV and SARS viruses. ...
We further reveal that ADP-ribosylation of RNA mediated by PARP10 and TRPT1 can be efficiently reversed by several cellular ADP-ribosylhydro …
67 results