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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
2000 1
2002 1
2005 1
2006 1
2007 1
2008 1
2010 1
2011 4
2012 5
2013 4
2014 4
2015 5
2016 6
2017 3
2018 4
2019 2
2020 2
2021 5
2022 4
2023 2
2024 0

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48 results

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Page 1
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, Gomez-Lorenzo MG, Franco V, Early AM, Lukens AK, Milner D, Furtado J, Gamo FJ, Winzeler EA, Volkman SK, Duffey M, Laleu B, Fidock DA, Wyllie S, Niles JC, Wirth DF. Bopp S, et al. Among authors: lukens ak. Nat Commun. 2023 Mar 16;14(1):1455. doi: 10.1038/s41467-023-36921-2. Nat Commun. 2023. PMID: 36927839 Free PMC article.
MalDA, Accelerating Malaria Drug Discovery.
Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, McNamara CW, Gamo FJ, Burrows J, Fidock DA, Goldberg DE, Gilbert IH, Wirth DF, Winzeler EA; Malaria Drug Accelerator Consortium. Yang T, et al. Among authors: lukens ak. Trends Parasitol. 2021 Jun;37(6):493-507. doi: 10.1016/j.pt.2021.01.009. Epub 2021 Feb 26. Trends Parasitol. 2021. PMID: 33648890 Free PMC article. Review.
Genome-Wide Association Studies of Drug-Resistance Determinants.
Volkman SK, Herman J, Lukens AK, Hartl DL. Volkman SK, et al. Among authors: lukens ak. Trends Parasitol. 2017 Mar;33(3):214-230. doi: 10.1016/j.pt.2016.10.001. Epub 2016 Oct 27. Trends Parasitol. 2017. PMID: 28179098 Review.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin D, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK. Summers RL, et al. Among authors: lukens ak. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8. doi: 10.1016/j.chembiol.2021.07.010. Epub 2021 Aug 3. Cell Chem Biol. 2022. PMID: 34348113 Free PMC article.
ML238: An Antimalarial Small Molecule of a Unique Structural Class.
Weiwer M, Mulrooney C, Massi D, Heidebrecht R, Wiegand R, Lukens AK, Dick J, Wirth D, Ekland E, Cheng CC, Zhao J, Yuan J, Su XZ, Johnson RL, Guha R, Dandapani S, Munoz B, Palmer M, Thomas C, Austin CP, Fidock D, Schreiber SL. Weiwer M, et al. Among authors: lukens ak. 2011 Apr 14 [updated 2011 Dec 12]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2011 Apr 14 [updated 2011 Dec 12]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23236647 Free Books & Documents. Review.
Prioritization of Molecular Targets for Antimalarial Drug Discovery.
Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, Wirth D, Wyllie S, Fidock DA, Baragaña B, Winzeler EA, Gilbert IH. Forte B, et al. Among authors: lukens ak. ACS Infect Dis. 2021 Oct 8;7(10):2764-2776. doi: 10.1021/acsinfecdis.1c00322. Epub 2021 Sep 15. ACS Infect Dis. 2021. PMID: 34523908 Free PMC article.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL. Kato N, et al. Among authors: lukens ak. Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7. Nature. 2016. PMID: 27602946 Free PMC article.
A broad analysis of resistance development in the malaria parasite.
Corey VC, Lukens AK, Istvan ES, Lee MCS, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, Prats S, Meister S, Tanaseichuk O, Wree M, Zhou Y, Willis PA, Gamo FJ, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA. Corey VC, et al. Among authors: lukens ak. Nat Commun. 2016 Jun 15;7:11901. doi: 10.1038/ncomms11901. Nat Commun. 2016. PMID: 27301419 Free PMC article.
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A, Bellale E, Panduga V, Shanbag G, Awasthy D, Landge S, Morayya S, Koushik K, Saralaya R, Raichurkar A, Rautela N, Roy Choudhury N, Ambady A, Nandishaiah R, Reddy J, Prabhakar KR, Menasinakai S, Rudrapatna S, Chatterji M, Jiménez-Díaz MB, Martínez MS, Sanz LM, Coburn-Flynn O, Fidock DA, Lukens AK, Wirth DF, Bandodkar B, Mukherjee K, McLaughlin RE, Waterson D, Rosenbrier-Ribeiro L, Hickling K, Balasubramanian V, Warner P, Hosagrahara V, Dudley A, Iyer PS, Narayanan S, Kavanagh S, Sambandamurthy VK. Hameed P S, et al. Among authors: lukens ak. Nat Commun. 2015 Mar 31;6:6715. doi: 10.1038/ncomms7715. Nat Commun. 2015. PMID: 25823686 Free PMC article.
48 results