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LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.
Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, Zhu Y, Bindra RS, Hansen JE, Dou J, Huang C, Zhou J. Chen Y, et al. Nat Cell Biol. 2020 Oct;22(10):1276-1285. doi: 10.1038/s41556-020-00586-6. Epub 2020 Oct 1. Nat Cell Biol. 2020. PMID: 33005030 Free PMC article.
We demonstrate that targeted delivery of the LRRC31 gene via nanoparticles improves the survival of tumour-bearing mice after irradiation. Collectively, our study suggests LRRC31 as a major DNA repair suppressor that can be targeted for cancer radiosensitizing thera …
We demonstrate that targeted delivery of the LRRC31 gene via nanoparticles improves the survival of tumour-bearing mice after irradia …
BDH1-mediated LRRC31 regulation dependent on histone lysine beta-hydroxybutyrylation to promote lung adenocarcinoma progression.
Huang J, Liang L, Jiang S, Liu Y, He H, Sun X, Li Y, Xie L, Tao Y, Cong L, Jiang Y. Huang J, et al. MedComm (2020). 2023 Dec 13;4(6):e449. doi: 10.1002/mco2.449. eCollection 2023 Dec. MedComm (2020). 2023. PMID: 38098610 Free PMC article.
The RNA sequencing analysis revealed leucine-rich repeat-containing protein 31 (LRRC31) as a downstream target gene regulated by BDH1. Ecologically expressed BDH1 hinders the accumulation of H3K9bhb in the transcription start site of LRRC31, consequently repressing …
The RNA sequencing analysis revealed leucine-rich repeat-containing protein 31 (LRRC31) as a downstream target gene regulated by BDH1 …
Comprehensive Analysis of NAFLD and the Therapeutic Target Identified.
Wen W, Wu P, Zhang Y, Chen Z, Sun J, Chen H. Wen W, et al. Front Cell Dev Biol. 2021 Sep 20;9:704704. doi: 10.3389/fcell.2021.704704. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34616724 Free PMC article.
The five candidate therapeutic targets were ENO3, CXCL10, INHBE, LRRC31, and OPTN. Moreover, the efficiency of hepatocyte adipogenesis decreased after OPTN knockout, confirming the potential use of OPTN as a new therapeutic target for NAFLD. ...
The five candidate therapeutic targets were ENO3, CXCL10, INHBE, LRRC31, and OPTN. Moreover, the efficiency of hepatocyte adipogenesi …
LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium.
D'Mello RJ, Caldwell JM, Azouz NP, Wen T, Sherrill JD, Hogan SP, Rothenberg ME. D'Mello RJ, et al. Mucosal Immunol. 2016 May;9(3):744-56. doi: 10.1038/mi.2015.98. Epub 2015 Oct 14. Mucosal Immunol. 2016. PMID: 26462420 Free PMC article.
LRRC31 had basal mRNA expression in colonic and airway mucosal epithelium. ...Notably, differentiated LRRC31-overexpressing EPC2s had decreased KLK expression and activity, whereas IL-13-treated, differentiated LRRC31 gene-silenced EPC2s had increased KLK exp …
LRRC31 had basal mRNA expression in colonic and airway mucosal epithelium. ...Notably, differentiated LRRC31-overexpressing EP …
Terc Gene Cluster Variants Predict Liver Telomere Length in Mice.
Zeid D, Mooney-Leber S, Seemiller LR, Goldberg LR, Gould TJ. Zeid D, et al. Cells. 2021 Oct 1;10(10):2623. doi: 10.3390/cells10102623. Cells. 2021. PMID: 34685603 Free PMC article.
Variants in a gene cluster upstream-adjacent to TERC on human chromosome 3, which includes genes APRM, LRRC31, LRRC34 and MYNN, have been associated with telomere length in several human populations. ...Although we found no significant impact of nicotine on liver aTL, this …
Variants in a gene cluster upstream-adjacent to TERC on human chromosome 3, which includes genes APRM, LRRC31, LRRC34 and MYNN, have …
A novel prognostic model for prostate cancer based on androgen biosynthetic and catabolic pathways.
Fan A, Zhang Y, Cheng J, Li Y, Chen W. Fan A, et al. Front Oncol. 2022 Nov 10;12:950094. doi: 10.3389/fonc.2022.950094. eCollection 2022. Front Oncol. 2022. PMID: 36439479 Free PMC article.
Subsequently, a novel prognostic model containing 13 genes (AFF3, B4GALNT4, CD38, CHRNA2, CST2, ADGRF5, KLK14, LRRC31, MT1F, MT1G, SFTPA2, SLC7A4, TDRD1) was constructed by univariate cox regression, lasso regression, and multivariate cox regression. ...
Subsequently, a novel prognostic model containing 13 genes (AFF3, B4GALNT4, CD38, CHRNA2, CST2, ADGRF5, KLK14, LRRC31, MT1F, MT1G, SF …
MMP9 integrates multiple immunoregulatory pathways that discriminate high suppressive activity of human mesenchymal stem cells.
Lavini-Ramos C, Silva HM, Soares-Schanoski A, Monteiro SM, Ferreira LRP, Pacanaro AP, Gomes S, Batista J, Faé K, Kalil J, Coelho V. Lavini-Ramos C, et al. Sci Rep. 2017 Apr 13;7(1):874. doi: 10.1038/s41598-017-00923-0. Sci Rep. 2017. PMID: 28408751 Free PMC article.
We here show that highly suppressive human adipose tissue-derived MSC (AdMSC) display and induce a differential immunologic profile, upon ongoing AdMSC suppressive activity, promoting: (i) early correlated inhibition of IFN-gamma and TNF-alpha production, along IL-10 increase, (i …
We here show that highly suppressive human adipose tissue-derived MSC (AdMSC) display and induce a differential immunologic profile, upon on …
Defining Essential Enhancers for Pluripotent Stem Cells Using a Features-Oriented CRISPR-Cas9 Screen.
Wang HF, Warrier T, Farran CA, Zheng ZH, Xing QR, Fullwood MJ, Zhang LF, Li H, Xu J, Lim TM, Loh YH. Wang HF, et al. Cell Rep. 2020 Oct 27;33(4):108309. doi: 10.1016/j.celrep.2020.108309. Cell Rep. 2020. PMID: 33113365 Free article.
Using RNA-seq and genomic 4C-seq, we further uncover a complex network of candidate CREs and their downstream target genes, which supports the growth and self-renewal of mESCs. Notably, an essential enhancer, CRE111, and its target, Lrrc31, form the important switch to mod …
Using RNA-seq and genomic 4C-seq, we further uncover a complex network of candidate CREs and their downstream target genes, which supports t …
Circulating Biomarkers for Predicting Infliximab Response in Rheumatoid Arthritis: A Systematic Bioinformatics Analysis.
Huang QL, Zhou FJ, Wu CB, Xu C, Qian WY, Fan DP, Cai XS. Huang QL, et al. Med Sci Monit. 2017 Apr 17;23:1849-1855. doi: 10.12659/msm.900897. Med Sci Monit. 2017. PMID: 28413214 Free PMC article.
RESULTS Eight microarray datasets were identified with 374 blood samples of RA patients, among which 191 (51.1%) were diagnosed as non-responders in the subsequent infliximab treatment. Five genes (FKBP1A, FGF12, ANO1, LRRC31, and AKR1D1) were associated with the efficacy …
RESULTS Eight microarray datasets were identified with 374 blood samples of RA patients, among which 191 (51.1%) were diagnosed as non-respo …
Telomere Maintenance Genes are associated with Type 2 Diabetes Susceptibility in Northwest Indian Population Group.
Sethi I, Sharma V, Sharma I, Singh G, Bhat GR, Bhanwer AJS, Sharma S, Rai E. Sethi I, et al. Sci Rep. 2020 Apr 15;10(1):6444. doi: 10.1038/s41598-020-63510-w. Sci Rep. 2020. PMID: 32296102 Free PMC article.
Amongst these five variants, rs9419958 (OBFC1), rs4783704 (TERF2), rs16847897 (TERC/LRRC31), rs10936599 (TERC/MYNN), and rs74019828 (CSNK2A2) showed significant association with T2D (at p-value 0.003, threshold set after Bonferroni correction) in the studied population. .. …
Amongst these five variants, rs9419958 (OBFC1), rs4783704 (TERF2), rs16847897 (TERC/LRRC31), rs10936599 (TERC/MYNN), and rs74019828 ( …
11 results