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Page 1
Preclinical activity of nanoliposomal irinotecan is governed by tumor deposition and intratumor prodrug conversion.
Cancer Res. 2014 Dec 1;74(23):7003-13. doi: 10.1158/0008-5472.CAN-14-0572. Epub 2014 Oct 1.
Cancer Res. 2014.
PMID: 25273092
Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer.
Leonard SC, Lee H, Gaddy DF, Klinz SG, Paz N, Kalra AV, Drummond DC, Chan DC, Bunn PA, Fitzgerald JB, Hendriks BS.
Leonard SC, et al. Among authors: kalra av.
Anticancer Drugs. 2017 Nov;28(10):1086-1096. doi: 10.1097/CAD.0000000000000545.
Anticancer Drugs. 2017.
PMID: 28857767
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Mucin overexpression limits the effectiveness of 5-FU by reducing intracellular drug uptake and antineoplastic drug effects in pancreatic tumours.
Kalra AV, Campbell RB.
Kalra AV, et al.
Eur J Cancer. 2009 Jan;45(1):164-73. doi: 10.1016/j.ejca.2008.10.008. Epub 2008 Dec 4.
Eur J Cancer. 2009.
PMID: 19046630
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Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain.
Kalra AV, Campbell RB.
Kalra AV, et al.
Br J Cancer. 2007 Oct 8;97(7):910-8. doi: 10.1038/sj.bjc.6603972. Epub 2007 Oct 2.
Br J Cancer. 2007.
PMID: 17912239
Free PMC article.
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Development of 5-FU and doxorubicin-loaded cationic liposomes against human pancreatic cancer: Implications for tumor vascular targeting.
Kalra AV, Campbell RB.
Kalra AV, et al.
Pharm Res. 2006 Dec;23(12):2809-17. doi: 10.1007/s11095-006-9113-3. Epub 2006 Oct 26.
Pharm Res. 2006.
PMID: 17066329
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