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Year Number of Results
2002 1
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2015 5
2016 1
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LncRNA SNHG6 Upregulates KPNA5 to Overcome Gemcitabine Resistance in Pancreatic Cancer via Sponging miR-944.
Gao G, Li X, Wu H, Huang LL, Lin YX, Huo Z, Xiang ZY, Zhou X. Gao G, et al. Pharmaceuticals (Basel). 2023 Jan 25;16(2):184. doi: 10.3390/ph16020184. Pharmaceuticals (Basel). 2023. PMID: 37259332 Free PMC article.
With the help of bioinformatic analysis and molecular approaches, we show that LncRNA SNHG6 can sponge miR-944, therefore causing the upregulation of the target gene KPNA5. In vitro experiments showed that LncRNA SNHG6 and KPNA5 suppress PC cell proliferation and co …
With the help of bioinformatic analysis and molecular approaches, we show that LncRNA SNHG6 can sponge miR-944, therefore causing the upregu …
Investigating Ebola virus pathogenicity using molecular dynamics.
Pappalardo M, Collu F, Macpherson J, Michaelis M, Fraternali F, Wass MN. Pappalardo M, et al. BMC Genomics. 2017 Aug 11;18(Suppl 5):566. doi: 10.1186/s12864-017-3912-2. BMC Genomics. 2017. PMID: 28812539 Free PMC article.
Here we used protein structural analysis and molecular dynamics to further elucidate the interaction between VP24 and KPNA5. RESULTS: As a control experiment, we compared the interaction of wild-type and R137A-mutant (known to affect KPNA5 binding) Ebola virus VP24 …
Here we used protein structural analysis and molecular dynamics to further elucidate the interaction between VP24 and KPNA5. RESULTS: …
Ebolavirus interferon antagonists-protein interaction perspectives to combat pathogenesis.
Banerjee A, Pal A, Pal D, Mitra P. Banerjee A, et al. Brief Funct Genomics. 2018 Nov 26;17(6):392-401. doi: 10.1093/bfgp/elx034. Brief Funct Genomics. 2018. PMID: 29140409 Review.
This protein interaction and protein design-based computational framework identified critical interacting residues of the VP (VP24) responsible for the formation of a stable complex with the human KPNA5 (karyopherin alpha proteins 5). The mutations of those critical residu …
This protein interaction and protein design-based computational framework identified critical interacting residues of the VP (VP24) responsi …
An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5.
Ding JN, Zhang YJ, Zhong H, Ao CC, Li J, Han JG. Ding JN, et al. Mol Biosyst. 2017 May 2;13(5):1031-1045. doi: 10.1039/c7mb00136c. Mol Biosyst. 2017. PMID: 28418440
The obtained results show that EBOV VP24 binding to KPNA5 will rigidify their binding-face, and both proteins will be compacted during binding. ...Meanwhile, by combining the decomposition of binding free energies (DC) with computational alanine scanning (CAS) results, it …
The obtained results show that EBOV VP24 binding to KPNA5 will rigidify their binding-face, and both proteins will be compacted durin …
VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.
Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF. Schwarz TM, et al. J Virol. 2017 Jan 31;91(4):e01715-16. doi: 10.1128/JVI.01715-16. Print 2017 Feb 15. J Virol. 2017. PMID: 27974555 Free PMC article.
Here, we evaluated eVP24, BDBV VP24 (bVP24), and RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and KPNA6). Using purified proteins, we demonstrated that each VP24 binds to each of the three NPI-1 KPNAs. bVP24, however, exhibited approximat …
Here, we evaluated eVP24, BDBV VP24 (bVP24), and RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and …
BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.
Kim NH, Yoshimaru T, Chen YA, Matsuo T, Komatsu M, Miyoshi Y, Tanaka E, Sasa M, Mizuguchi K, Katagiri T. Kim NH, et al. PLoS One. 2015 Jun 8;10(6):e0127707. doi: 10.1371/journal.pone.0127707. eCollection 2015. PLoS One. 2015. PMID: 26052702 Free PMC article.
Here, we report that BIG3 blocks the estrogen (E2)-dependent nuclear import of PHB2 via the karyopherin alpha (KPNA) family in breast cancer cells. We found that overexpressed PHB2 interacted with KPNA1, KPNA5, and KPNA6, thereby leading to the E2-dependent translocation o …
Here, we report that BIG3 blocks the estrogen (E2)-dependent nuclear import of PHB2 via the karyopherin alpha (KPNA) family in breast cancer …
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer.
Mehmood R, Jibiki K, Shibazaki N, Yasuhara N. Mehmood R, et al. Heliyon. 2021 Jan 30;7(1):e06039. doi: 10.1016/j.heliyon.2021.e06039. eCollection 2021 Jan. Heliyon. 2021. PMID: 33553736 Free PMC article.
Interestingly, we identified that many of these molecules are either mutated or have dysregulated expression in breast cancer. Strikingly, some of the molecules, namely, KPNA2, KPNA3, KPNA5, IPO8, TNPO1, XPOT, XPO7 and CSE1L were correlated with poor patient survival. ...
Interestingly, we identified that many of these molecules are either mutated or have dysregulated expression in breast cancer. Strikingly, s …
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK. Xu W, et al. Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008. Cell Host Microbe. 2014. PMID: 25121748 Free PMC article.
Ebola virus VP24 protein (eVP24) binds KPNA to inhibit PY-STAT1 nuclear transport and render cells refractory to IFNs. We describe the structure of human KPNA5 C terminus in complex with eVP24. In the complex, eVP24 recognizes a unique nonclassical nuclear localization sig …
Ebola virus VP24 protein (eVP24) binds KPNA to inhibit PY-STAT1 nuclear transport and render cells refractory to IFNs. We describe the struc …
Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.
Pappalardo M, Juliá M, Howard MJ, Rossman JS, Michaelis M, Wass MN. Pappalardo M, et al. Sci Rep. 2016 Mar 24;6:23743. doi: 10.1038/srep23743. Sci Rep. 2016. PMID: 27009368 Free PMC article.
Three VP24 SDPs (T131S, M136L, Q139R) are likely to impair VP24 binding to human karyopherin alpha5 (KPNA5) and therefore inhibition of interferon signaling. Since VP24 is critical for Ebolavirus adaptation to novel hosts, and only a few SDPs distinguish Reston virus VP24 …
Three VP24 SDPs (T131S, M136L, Q139R) are likely to impair VP24 binding to human karyopherin alpha5 (KPNA5) and therefore inhibition …
Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.
Jiao X, Wood LD, Lindman M, Jones S, Buckhaults P, Polyak K, Sukumar S, Carter H, Kim D, Karchin R, Sjöblom T. Jiao X, et al. Genes Chromosomes Cancer. 2012 May;51(5):480-9. doi: 10.1002/gcc.21935. Epub 2012 Feb 3. Genes Chromosomes Cancer. 2012. PMID: 22302350 Free PMC article.
Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3C …
Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, I …
20 results