Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway.
Wang C, Feng X, Su D, Chen Z, Wang S, Tang M, Huang M, Nie L, Zhang H, Li S, Yin L, Johnson RL, Hart T, Chen J.
Wang C, et al.
Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2121779119. doi: 10.1073/pnas.2121779119. Epub 2022 Jun 15.
Proc Natl Acad Sci U S A. 2022.
PMID: 35704761
Free PMC article.
We found that Kirrel1 loss markedly promoted tumor growth in vivo. Moreover, KIRREL was significantly enriched in a separate CRISPR screen based on a specific Hippo pathway reporter. Further studies revealed that KIRREL binds directly to SAV1 to activate the Hippo t …
We found that Kirrel1 loss markedly promoted tumor growth in vivo. Moreover, KIRREL was significantly enriched in a separate CRISPR s …