Integrating fluorescent biosensor data using computational models.
Methods Mol Biol. 2014.
PMID: 24052393
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Integrating fluorescent biosensor data using computational models.
Methods Mol Biol. 2014;1071:227-48. doi: 10.1007/978-1-62703-622-1_18.
Methods Mol Biol. 2014.
PMID: 24052393
This book chapter provides a tutorial on how to construct computational models of signaling networks for the integration and interpretation of FRET-based biosensor data. ...Experimental acquisition and processing of FRET biosensor data …
This book chapter provides a tutorial on how to construct computational models of signaling networks for the integration …
FIBS-enabled noninvasive metabolic profiling.
J Vis Exp. 2014 Feb 3;(84):e51200. doi: 10.3791/51200.
J Vis Exp. 2014.
PMID: 24513729
Free PMC article.
In the era of computational biology, new high throughput experimental systems are necessary in order to populate and refine models so that they can be validated for predictive purposes. ...One particular class of in vivo biosensors that has found applications …
In the era of computational biology, new high throughput experimental systems are necessary in order to populate and refine models …
Visualizing and quantifying adhesive signals.
Curr Opin Cell Biol. 2008 Oct;20(5):541-50. doi: 10.1016/j.ceb.2008.05.004. Epub 2008 Jun 27.
Curr Opin Cell Biol. 2008.
PMID: 18586481
Free PMC article.
Review.
Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration …
Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the ac …
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors.
Exp Biol Med (Maywood). 2021 Nov;246(22):2420-2441. doi: 10.1177/15353702211009228. Epub 2021 May 6.
Exp Biol Med (Maywood). 2021.
PMID: 33957803
Free PMC article.
Review.
Therefore, a platform has evolved initially focused on human biomimetic liver microphysiology systems that integrates fluorescent protein biosensors along with other key metrics, the microphysiology systems database, and quantitative systems pharmacology. Qua …
Therefore, a platform has evolved initially focused on human biomimetic liver microphysiology systems that integrates fluorescent …
Integrated Strategies to Gain a Systems-Level View of Dynamic Signaling Networks.
Methods Enzymol. 2017;589:133-170. doi: 10.1016/bs.mie.2017.01.016. Epub 2017 Mar 7.
Methods Enzymol. 2017.
PMID: 28336062
Free PMC article.
Therefore, to gain a more comprehensive view of cell signaling processes, it is important to understand how signaling networks behave at the systems level. This requires integrated strategies that combine quantitative experimental data with computational m …
Therefore, to gain a more comprehensive view of cell signaling processes, it is important to understand how signaling networks behave at the …
A computational reaction-diffusion model for the analysis of transport-limited kinetics.
Anal Chem. 1999 Dec 1;71(23):5405-12. doi: 10.1021/ac990672b.
Anal Chem. 1999.
PMID: 21662737
We present a computational, transport-kinetic model that can be used to analyze transport-limited biosensor data. ...To demonstrate the feasibility of this model, we use it to analyze data collected for the binding of fluorescently …
We present a computational, transport-kinetic model that can be used to analyze transport-limited biosensor data …
Fluocell for Ratiometric and High-Throughput Live-Cell Image Visualization and Quantitation.
Front Phys. 2019 Oct;7:154. doi: 10.3389/fphy.2019.00154. Epub 2019 Oct 23.
Front Phys. 2019.
PMID: 33163483
Free PMC article.
The application of Fluocell is demonstrated by the ratiometric analysis of intensity images for several single-chain Forster (or fluorescence) resonance energy transfer (FRET)-based biosensors, allowing efficient quantification of dynamic molecular activities in a h …
The application of Fluocell is demonstrated by the ratiometric analysis of intensity images for several single-chain Forster (or fluoresc …
A human liver microphysiology platform for investigating physiology, drug safety, and disease models.
Exp Biol Med (Maywood). 2016 Jan;241(1):101-14. doi: 10.1177/1535370215592121. Epub 2015 Jul 22.
Exp Biol Med (Maywood). 2016.
PMID: 26202373
Free PMC article.
This paper describes the development and characterization of a microphysiology platform for drug safety and efficacy in liver models of disease that includes a human, 3D, microfluidic, four-cell, sequentially layered, self-assembly liver model (SQL-SAL); fluoresc …
This paper describes the development and characterization of a microphysiology platform for drug safety and efficacy in liver models …
Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.
J Biol Chem. 2008 Nov 14;283(46):31531-40. doi: 10.1074/jbc.M804902200. Epub 2008 Sep 12.
J Biol Chem. 2008.
PMID: 18790737
Free PMC article.
When pacing frequency is raised from 0.1 to 1.0 Hz, the higher affinity BsCaM-2 demonstrates significant elevation of diastolic Ca2+-CaM binding compared with the lower affinity BsCaM-45. Biochemically detailed computational models of Ca2+-CaM biosensors in b …
When pacing frequency is raised from 0.1 to 1.0 Hz, the higher affinity BsCaM-2 demonstrates significant elevation of diastolic Ca2+-CaM bin …
Determining the characteristics of water pollutants by neural sensors and pattern recognition methods.
J Chromatogr A. 1996 Jan 26;722(1-2):233-43. doi: 10.1016/0021-9673(95)00571-4.
J Chromatogr A. 1996.
PMID: 9019297
In this paper we have researched the influence of pollutants on such biological objects as photosynthesizing systems in order to reveal the capabilities and features of their application as the controlling sensor in integral ecological monitoring microsystems. It is propos …
In this paper we have researched the influence of pollutants on such biological objects as photosynthesizing systems in order to reveal the …
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