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2003 1
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Page 1
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Wang M, He T, Meng D, Lv W, Ye J, Cheng L, Hu J. Wang M, et al. J Proteome Res. 2023 Dec 1;22(12):3854-3865. doi: 10.1021/acs.jproteome.3c00518. Epub 2023 Nov 13. J Proteome Res. 2023. PMID: 37955350
Cell experiments showed that BZW2 fostered the malignant progression of LUAD by promoting glycolysis-mediated lactate production and lactylation of IDH3G. In a compelling in vivo validation, the inhibition of Hla could suppress the malignant progression of LUAD. ...BZW2 co …
Cell experiments showed that BZW2 fostered the malignant progression of LUAD by promoting glycolysis-mediated lactate production and lactyla …
Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer.
Jiang J, Huang D, Jiang Y, Hou J, Tian M, Li J, Sun L, Zhang Y, Zhang T, Li Z, Li Z, Tong S, Ma Y. Jiang J, et al. Front Oncol. 2021 Jun 2;11:647559. doi: 10.3389/fonc.2021.647559. eCollection 2021. Front Oncol. 2021. PMID: 34150616 Free PMC article.
Further exploration found that mRNA levels of glycolytic enzymes (HK-1, PKM) and TCA cycle enzymes (SDHA, IDH3G) are respectively down-regulated and up-regulated by lactate, and increased histone lactylation was observed in promoters of HK-1 and IDH3G via chromatin …
Further exploration found that mRNA levels of glycolytic enzymes (HK-1, PKM) and TCA cycle enzymes (SDHA, IDH3G) are respectively dow …
A prognostic signature of cuproptosis and TCA-related genes for hepatocellular carcinoma.
Zhang Q, Ma L, Zhou H, Zhou Y, Liu S, Li Q. Zhang Q, et al. Front Oncol. 2022 Oct 17;12:1040736. doi: 10.3389/fonc.2022.1040736. eCollection 2022. Front Oncol. 2022. PMID: 36324575 Free PMC article.
RESULTS: TCA and copper malnutrition-related genes (CDKN2A, IDH1, OGDHL, IDH3G, IDH3B, GLS, DLAT, LIPT1) were finally included. According to the risk score, they were divided into high-risk and low-risk groups. ...
RESULTS: TCA and copper malnutrition-related genes (CDKN2A, IDH1, OGDHL, IDH3G, IDH3B, GLS, DLAT, LIPT1) were finally included. Accor …
Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer's disease.
Jia D, Wang F, Yu H. Jia D, et al. Front Neurosci. 2023 Jul 27;17:1206688. doi: 10.3389/fnins.2023.1206688. eCollection 2023. Front Neurosci. 2023. PMID: 37575300 Free PMC article.
Pearson analysis of the TCA cycle genes with Abeta, Tau and mini-mental state examination (MMSE) revealed several significant correlated genes, including pyruvate dehydrogenase complex subunit (PDHB), isocitrate dehydrogenase subunits (IDH3B, IDH3G), 2-oxoglutarate dehydro …
Pearson analysis of the TCA cycle genes with Abeta, Tau and mini-mental state examination (MMSE) revealed several significant correlated gen …
Differential expression of aerobic oxidative metabolism-related proteins in diabetic urinary exosomes.
Liu T, Wang Y, Zhao M, Jiang J, Li T, Zhang M. Liu T, et al. Front Endocrinol (Lausanne). 2022 Sep 14;13:992827. doi: 10.3389/fendo.2022.992827. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36187097 Free PMC article.
Compared with normal control, the expressions of PFKM, GAPDH, ACO2 and MDH2 in diabetic patients were decreased, and the expression of IDH3G was increased. The concentrations of PFKM, GAPDH and ACO2 in urinary exosomes were linearly correlated with the expression of MDH2 ( …
Compared with normal control, the expressions of PFKM, GAPDH, ACO2 and MDH2 in diabetic patients were decreased, and the expression of ID …
Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms.
Okamoto K, Matsuzaka Y, Yoshikawa Y, Takaki A, Kulski JK, Tamiya G, Inoko H. Okamoto K, et al. Gene. 2003 Dec 24;323:141-8. doi: 10.1016/j.gene.2003.09.014. Gene. 2003. PMID: 14659887
The full-length cDNA sequence (1037 bp) was isolated from the human testis 5'-3'-RACE cDNA libraries and found to have 83% nucleotide sequence identity with part of the IDH3G (isocitrate dehydrogenase 3 gamma). The IDH3GL gene consists of 3 exons spanning approximately 220 …
The full-length cDNA sequence (1037 bp) was isolated from the human testis 5'-3'-RACE cDNA libraries and found to have 83% nucleotide sequen …
Gene Regulation Network of Prognostic Biomarker YAP1 in Human Cancers: An Integrated Bioinformatics Study.
Wu B, Tang X, Ke H, Zhou Q, Zhou Z, Tang S, Ke R. Wu B, et al. Pathol Oncol Res. 2021 Jun 11;27:1609768. doi: 10.3389/pore.2021.1609768. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34257617 Free PMC article.
The MCODE analysis identified three hub genes including CHCHD1, IDH3G and NDUFAF5. Conclusion: Our findings showed that the YAP1 overexpression could be a biomarker for poor prognosis in ACC, LGG and PAAD. ...
The MCODE analysis identified three hub genes including CHCHD1, IDH3G and NDUFAF5. Conclusion: Our findings showed that the YAP1 over …
β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion.
Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS. Reynolds MS, et al. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E186-201. doi: 10.1152/ajpendo.00022.2016. Epub 2016 May 24. Am J Physiol Endocrinol Metab. 2016. PMID: 27221116 Free article.
We establish that knockdown of Nr4a1 and Nr4a3 results in decreased expression of the mitochondrial dehydrogenase subunits Idh3g and Sdhb. We demonstrate that loss of Nr4a1 and Nr4a3 impedes production of ATP and ultimately inhibits glucose-stimulated insulin secretion. .. …
We establish that knockdown of Nr4a1 and Nr4a3 results in decreased expression of the mitochondrial dehydrogenase subunits Idh3g and …
Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.
Landi A, Vermeire J, Iannucci V, Vanderstraeten H, Naessens E, Bentahir M, Verhasselt B. Landi A, et al. Retrovirology. 2014 Dec 13;11:118. doi: 10.1186/s12977-014-0118-4. Retrovirology. 2014. PMID: 25496667 Free PMC article.
By this stringent validation set-up, we could demonstrate that the knock-down of DNM3 (dynamin 3), SNX22 (sorting nexin 22), ATP6AP1 (ATPase, H+ Transporting, Lysosomal Accessory Protein 1), HRBL (HIV-Rev binding protein Like), IDH3G (Isocitrate dehydrogenase), HSP90B1 (He …
By this stringent validation set-up, we could demonstrate that the knock-down of DNM3 (dynamin 3), SNX22 (sorting nexin 22), ATP6AP1 (ATPase …
The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells.
Myers SA, Nield A, Chew GS, Myers MA. Myers SA, et al. PLoS One. 2013 Nov 12;8(11):e79316. doi: 10.1371/journal.pone.0079316. eCollection 2013. PLoS One. 2013. PMID: 24265765 Free PMC article.
This was concomitant with a reduction in the expression of genes involved in glucose metabolism including Agl, Dlst, Galm, Gbe1, Idh3g, Pck2, Pgam2, Pgm2, Phkb, Pygm, Tpi1, Gusb and Glut4. Glut4 protein expression was also reduced and insulin-stimulated glycogen synthesis …
This was concomitant with a reduction in the expression of genes involved in glucose metabolism including Agl, Dlst, Galm, Gbe1, Idh3g …
16 results