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Caspase-2 cleavage of tau reversibly impairs memory.
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH. Zhao X, et al. Among authors: hlynialuk c. Nat Med. 2016 Nov;22(11):1268-1276. doi: 10.1038/nm.4199. Epub 2016 Oct 10. Nat Med. 2016. PMID: 27723722
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
Singh G, Liu P, Yao KR, Strasser JM, Hlynialuk C, Leinonen-Wright K, Teravskis PJ, Choquette JM, Ikramuddin J, Bresinsky M, Nelson KM, Liao D, Ashe KH, Walters MA, Pockes S. Singh G, et al. Among authors: hlynialuk c. ACS Chem Neurosci. 2022 May 18;13(10):1549-1557. doi: 10.1021/acschemneuro.2c00100. Epub 2022 May 6. ACS Chem Neurosci. 2022. PMID: 35522720 Free PMC article.
Aβ∗56 is a stable oligomer that impairs memory function in mice.
Liu P, Lapcinski IP, Hlynialuk CJW, Steuer EL, Loude TJ Jr, Shapiro SL, Kemper LJ, Ashe KH. Liu P, et al. Among authors: hlynialuk cjw. iScience. 2024 Feb 15;27(3):109239. doi: 10.1016/j.isci.2024.109239. eCollection 2024 Mar 15. iScience. 2024. PMID: 38433923 Free PMC article.
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
Steuer EL, Kemper LJ, Hlynialuk CJW, Leinonen-Wright K, Montonye ML, Lapcinski IP, Forster CL, Ashe KH, Liu P. Steuer EL, et al. Among authors: hlynialuk cjw. J Neurosci. 2022 Jun 8;42(23):4737-4754. doi: 10.1523/JNEUROSCI.0543-22.2022. Epub 2022 May 4. J Neurosci. 2022. PMID: 35508385 Free PMC article.
11 results