Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1982 1
1983 1
1984 3
1985 1
1986 1
1988 2
1989 2
1990 3
1991 1
1992 1
1993 4
1994 1
1996 5
1997 1
1998 4
1999 2
2000 2
2001 4
2002 5
2003 4
2004 8
2005 6
2006 8
2007 8
2008 12
2009 4
2010 6
2011 6
2012 6
2013 9
2014 8
2015 7
2016 10
2017 11
2018 8
2019 2
2020 4
2021 9
2022 10
2023 10
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

181 results

Results by year

Filters applied: . Clear all
Page 1
HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer.
Kuo KT, Lin CH, Wang CH, Pikatan NW, Yadav VK, Fong IH, Yeh CT, Lee WH, Huang WC. Kuo KT, et al. Int J Mol Sci. 2022 Jan 31;23(3):1663. doi: 10.3390/ijms23031663. Int J Mol Sci. 2022. PMID: 35163585 Free PMC article.
HNMT shRNA and overexpression plasmids were used to explore HNMT functions in vitro and in vivo. We also examined miRNAs that may target HNMT and investigated HNMT/HER2's role on NSCLC cells' antioxidant properties. ...
HNMT shRNA and overexpression plasmids were used to explore HNMT functions in vitro and in vivo. We also examined miRNAs that …
Histamine N-Methyltransferase in the Brain.
Yoshikawa T, Nakamura T, Yanai K. Yoshikawa T, et al. Int J Mol Sci. 2019 Feb 10;20(3):737. doi: 10.3390/ijms20030737. Int J Mol Sci. 2019. PMID: 30744146 Free PMC article. Review.
Recently, we have phenotyped Hnmt-deficient mice to elucidate the importance of HNMT in the central nervous system. Hnmt disruption resulted in a robust increase in brain histamine concentration, demonstrating the essential role of HNMT in the brain hi …
Recently, we have phenotyped Hnmt-deficient mice to elucidate the importance of HNMT in the central nervous system. Hnmt …
Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
McClain JL, Morales-Soto W, Gonzales J, Parmar V, Demireva EY, Gulbransen BD. McClain JL, et al. Biomolecules. 2023 Nov 14;13(11):1651. doi: 10.3390/biom13111651. Biomolecules. 2023. PMID: 38002333 Free PMC article.
Here, we show that enteric glia contribute to histamine clearance in the enteric nervous system (ENS) through their expression of the enzyme histamine N-methyltransferase (HNMT). Glial HNMT expression was initially assessed using immunolabeling and gene expression, …
Here, we show that enteric glia contribute to histamine clearance in the enteric nervous system (ENS) through their expression of the enzyme …
Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Jiménez-Jiménez FJ, et al. Medicine (Baltimore). 2016 Jul;95(27):e4147. doi: 10.1097/MD.0000000000004147. Medicine (Baltimore). 2016. PMID: 27399132 Free PMC article. Review.
RESULTS: The meta-analysis included 4 eligible case-control association studies for the HNMT rs11558538 SNP and the risk for PD (2108 patients, 2158 controls). ...CONCLUSION: The present meta-analysis confirms published evidence suggesting that the HNMT rs11558538 m …
RESULTS: The meta-analysis included 4 eligible case-control association studies for the HNMT rs11558538 SNP and the risk for PD (2108 …
Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson's Disease in a Northern Chinese Population.
Dai C, Zhang Y, Zhan X, Tian M, Pang H. Dai C, et al. Neuropsychiatr Dis Treat. 2021 May 27;17:1689-1695. doi: 10.2147/NDT.S304062. eCollection 2021. Neuropsychiatr Dis Treat. 2021. PMID: 34079266 Free PMC article.
The genes for synaptosome-associated protein of 25 kDa (SNAP25), histamine-N-methyltransferase (HNMT), FCH and double SH3 domains 1 (FCHSD1) and dopamine beta-hydroxylase (DBH) are candidate loci and have not been studied in a northern Chinese population. We explored the g …
The genes for synaptosome-associated protein of 25 kDa (SNAP25), histamine-N-methyltransferase (HNMT), FCH and double SH3 domains 1 ( …
Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4-tetrahydroacridine (tacrine) and by beta-carbolines.
Cumming P, Vincent SR. Cumming P, et al. Biochem Pharmacol. 1992 Sep 1;44(5):989-92. doi: 10.1016/0006-2952(92)90133-4. Biochem Pharmacol. 1992. PMID: 1530666
Structural fragments of tacrine were less potent inhibitors of rat brain HNMT than was tacrine itself. Harmaline and a number of other beta-carbolines inhibited HNMT with IC50 values in the range of 1-10 microM. ...These findings are discussed in the context of mech …
Structural fragments of tacrine were less potent inhibitors of rat brain HNMT than was tacrine itself. Harmaline and a number of othe …
Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.
Jiménez-Jiménez FJ, García-Martín E, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, Agúndez JA. Jiménez-Jiménez FJ, et al. J Neural Transm (Vienna). 2017 Mar;124(3):285-291. doi: 10.1007/s00702-016-1645-z. Epub 2016 Nov 11. J Neural Transm (Vienna). 2017. PMID: 27837280
We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were …
We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqM …
Histamine pharmacogenomics.
García-Martín E, Ayuso P, Martínez C, Blanca M, Agúndez JA. García-Martín E, et al. Pharmacogenomics. 2009 May;10(5):867-83. doi: 10.2217/pgs.09.26. Pharmacogenomics. 2009. PMID: 19450133 Review.
Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N-methyltransferase (HNMT), as well as histamine receptor genes, often have pointed to polymorphisms that …
Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine ox …
Mapping of the binding sites of human histamine N-methyltransferase (HNMT) monoclonal antibodies.
Schwelberger HG, Feurle J, Houen G. Schwelberger HG, et al. Inflamm Res. 2017 Nov;66(11):1021-1029. doi: 10.1007/s00011-017-1086-7. Epub 2017 Aug 8. Inflamm Res. 2017. PMID: 28791419 Free PMC article.
METHODS: Fragments of human HNMT were expressed as glutathione S-transferase fusion proteins that were used for testing antibody binding on immunoblots. ...Antibodies binding non-overlapping epitopes will facilitate analyses of all clinically relevant variants described fo …
METHODS: Fragments of human HNMT were expressed as glutathione S-transferase fusion proteins that were used for testing antibody bind …
Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson's Disease.
Semenova EI, Partevian SA, Shulskaya MV, Rudenok MM, Lukashevich MV, Baranova NM, Doronina OB, Doronina KS, Rosinskaya AV, Fedotova EY, Illarioshkin SN, Slominsky PA, Shadrina MI, Alieva AK. Semenova EI, et al. Biomed Res Int. 2023 Nov 20;2023:9412776. doi: 10.1155/2023/9412776. eCollection 2023. Biomed Res Int. 2023. PMID: 38027039 Free PMC article.
Thus, in the present work, we performed an analysis of changes in the expression of the genes ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT in the peripheral blood of patients with early stages of PD (stages 1 and 2 of the Hoehn-Yahr scale). We found significant and PD-specif …
Thus, in the present work, we performed an analysis of changes in the expression of the genes ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT …
181 results