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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 3
1981 1
1982 1
1984 2
1985 3
1986 2
1987 2
1988 2
1989 5
1990 8
1991 4
1992 7
1993 6
1994 8
1995 6
1996 7
1997 6
1998 5
1999 8
2000 2
2001 7
2002 6
2003 9
2004 8
2005 8
2006 8
2007 9
2008 10
2009 13
2010 16
2011 16
2012 19
2013 15
2014 8
2015 8
2016 17
2017 14
2018 23
2019 15
2020 30
2021 17
2022 26
2023 20
2024 6

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371 results

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Page 1
Novel Hexb-based tools for studying microglia in the CNS.
Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer-Luehmann M, Knobeloch KP, Prinz M. Masuda T, et al. Nat Immunol. 2020 Jul;21(7):802-815. doi: 10.1038/s41590-020-0707-4. Epub 2020 Jun 15. Nat Immunol. 2020. PMID: 32541832
Next, we generated Hexb(tdTomato) mice to stably monitor microglia behavior in vivo. Finally, the Hexb locus was employed for tamoxifen-inducible Cre-mediated gene manipulation in microglia and for fate mapping of microglia but not CAMs. ...
Next, we generated Hexb(tdTomato) mice to stably monitor microglia behavior in vivo. Finally, the Hexb locus was employed for …
Microglia-Specific Promoter Activities of HEXB Gene.
Shah S, Wong LM, Ellis K, Bodnar B, Saribas S, Ting J, Wei Z, Tang Y, Wang X, Wang H, Ling B, Margolis DM, Garcia JV, Hu W, Jiang G. Shah S, et al. Front Cell Neurosci. 2022 Mar 10;16:808598. doi: 10.3389/fncel.2022.808598. eCollection 2022. Front Cell Neurosci. 2022. PMID: 35360489 Free PMC article.
Dual reporter and serial deletion assays identified the critical role of the natural 5' untranslated region (-97 bp related to the first ATG) in driving transcriptional activity of the mouse Hexb gene. The native promoter region of mouse, human, and monkey HEXB are …
Dual reporter and serial deletion assays identified the critical role of the natural 5' untranslated region (-97 bp related to the first ATG …
Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development.
Kuil LE, López Martí A, Carreras Mascaro A, van den Bosch JC, van den Berg P, van der Linde HC, Schoonderwoerd K, Ruijter GJG, van Ham TJ. Kuil LE, et al. Glia. 2019 Sep;67(9):1705-1718. doi: 10.1002/glia.23641. Epub 2019 May 29. Glia. 2019. PMID: 31140649 Free PMC article.
Hexb deficient zebrafish (hexb(-/-) ) showed lysosomal abnormalities already early in development both in radial glia, which are the neuronal and glial progenitors, and in microglia. Additionally, at 5 days postfertilization, hexb(-/-) zebrafish showed reduce
Hexb deficient zebrafish (hexb(-/-) ) showed lysosomal abnormalities already early in development both in radial glia, which a
AAV gene therapy for Tay-Sachs disease.
Flotte TR, Cataltepe O, Puri A, Batista AR, Moser R, McKenna-Yasek D, Douthwright C, Gernoux G, Blackwood M, Mueller C, Tai PWL, Jiang X, Bateman S, Spanakis SG, Parzych J, Keeler AM, Abayazeed A, Rohatgi S, Gibson L, Finberg R, Barton BA, Vardar Z, Shazeeb MS, Gounis M, Tifft CJ, Eichler FS, Brown RH Jr, Martin DR, Gray-Edwards HL, Sena-Esteves M. Flotte TR, et al. Nat Med. 2022 Feb;28(2):251-259. doi: 10.1038/s41591-021-01664-4. Epub 2022 Feb 10. Nat Med. 2022. PMID: 35145305 Free PMC article.
Patient TSD-001 was treated at 30 months with an equimolar mix of AAVrh8-HEXA and AAVrh8-HEXB administered intrathecally (i.t.), with 75% of the total dose (1 10(14) vector genomes (vg)) in the cisterna magna and 25% at the thoracolumbar junction. ...
Patient TSD-001 was treated at 30 months with an equimolar mix of AAVrh8-HEXA and AAVrh8-HEXB administered intrathecally (i.t.), with …
Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease.
Whyte LS, Fourrier C, Hassiotis S, Lau AA, Trim PJ, Hein LK, Hattersley KJ, Bensalem J, Hopwood JJ, Hemsley KM, Sargeant TJ. Whyte LS, et al. IBRO Neurosci Rep. 2022 Jan 20;12:131-141. doi: 10.1016/j.ibneur.2022.01.004. eCollection 2022 Jun. IBRO Neurosci Rep. 2022. PMID: 35146484 Free PMC article.
App (KI/KI) and Hexb (+/-) mice were crossed and evaluated in a behavioural test battery. ...Hexb heterozygosity caused detectable changes in the brain and in the behaviour of an AD model mouse, consistent with previous reports that described a biochemical relations …
App (KI/KI) and Hexb (+/-) mice were crossed and evaluated in a behavioural test battery. ...Hexb heterozygosity caused detect …
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology.
Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. Sierksma A, et al. EMBO Mol Med. 2020 Mar 6;12(3):e10606. doi: 10.15252/emmm.201910606. Epub 2020 Jan 17. EMBO Mol Med. 2020. PMID: 31951107 Free PMC article.
We identify in this module 7 established AD risk genes (APOE, CLU, INPP5D, CD33, PLCG2, SPI1, and FCER1G) and 11 AD GWAS genes below the genome-wide significance threshold (GPC2, TREML2, SYK, GRN, SLC2A5, SAMSN1, PYDC1, HEXB, RRBP1, LYN, and BLNK), that become significantl …
We identify in this module 7 established AD risk genes (APOE, CLU, INPP5D, CD33, PLCG2, SPI1, and FCER1G) and 11 AD GWAS genes below the gen …
The GM2 gangliosidoses databases: allelic variation at the HEXA, HEXB, and GM2A gene loci.
Cordeiro P, Hechtman P, Kaplan F. Cordeiro P, et al. Genet Med. 2000 Nov-Dec;2(6):319-27. doi: 10.1097/00125817-200011000-00003. Genet Med. 2000. PMID: 11339652 Free article. Review.
The genes responsible for these disorders are HEXA (Tay-Sachs disease and variants), HEXB (Sandhoff disease and variants), and GM2A (AB variant of GM2 gangliosidosis). We report the establishment of three relational locus-specific databases recording allelic variation at t …
The genes responsible for these disorders are HEXA (Tay-Sachs disease and variants), HEXB (Sandhoff disease and variants), and GM2A ( …
Sandhoff Disease.
Xiao C, Tifft C, Toro C. Xiao C, et al. 2022 Apr 14. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2022 Apr 14. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 35420740 Free Books & Documents. Review.
GENETIC COUNSELING: Sandhoff disease is inherited in an autosomal recessive manner. If both parents are known to be heterozygous for a HEXB pathogenic variant, each sib of an affected individual has at conception a 25% chance of being affected, a 50% chance of being an asy …
GENETIC COUNSELING: Sandhoff disease is inherited in an autosomal recessive manner. If both parents are known to be heterozygous for a HE
Functionality of a bicistronic construction containing HEXA and HEXB genes encoding beta-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses.
Shaimardanova AA, Chulpanova DS, Solovyeva VV, Aimaletdinov AM, Rizvanov AA. Shaimardanova AA, et al. Neural Regen Res. 2022 Jan;17(1):122-129. doi: 10.4103/1673-5374.314310. Neural Regen Res. 2022. PMID: 34100447 Free PMC article.
Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB and hUCBMCs-HEXA-HEXB was increased by 23 and 8 times, respectively, compared with the conditioned medium of native cells. Western …
Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB
371 results