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Genomic and functional conservation of sedative-hypnotic targets in the zebrafish.
Renier C, Faraco JH, Bourgin P, Motley T, Bonaventure P, Rosa F, Mignot E. Renier C, et al. Pharmacogenet Genomics. 2007 Apr;17(4):237-53. doi: 10.1097/FPC.0b013e3280119d62. Pharmacogenet Genomics. 2007. PMID: 17496723
We investigated the effects of sedative hypnotics commonly used in humans on zebrafish locomotor activity and identified the corresponding genomic and receptor binding targets. ...CONCLUSIONS: These results demonstrate conservation of gen …
We investigated the effects of sedative hypnotics commonly used in humans on zebrafish locomotor activity and identifie …
Drug-selective Anesthetic Insensitivity of Zebrafish Lacking gamma-Aminobutyric Acid Type A Receptor beta3 Subunits.
Yang X, Jounaidi Y, Mukherjee K, Fantasia RJ, Liao EC, Yu B, Forman SA. Yang X, et al. Anesthesiology. 2019 Dec;131(6):1276-1291. doi: 10.1097/ALN.0000000000002963. Anesthesiology. 2019. PMID: 31567362 Free PMC article.
Comparing beta3 versus wild-type sedative EC50s revealed a pattern similar to hypnosis. CONCLUSIONS: Global beta3 zebrafish are selectively insensitive to the same few sedative-hypnotics previously reported in beta3 transgenic mice, indicating phylogen …
Comparing beta3 versus wild-type sedative EC50s revealed a pattern similar to hypnosis. CONCLUSIONS: Global beta3 zebrafish ar …