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Page 1
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities.
Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G, McFarlane C, Forrester T, Barton SJ, Leow MK, Antoun E, Charpagne A, Seng Chong Y, Descombes P, Feng L, Francis-Emmanuel P, Garratt ES, Giner MP, Green CO, Karaz S, Kothandaraman N, Marquis J, Metairon S, Moco S, Nelson G, Ngo S, Pleasants T, Raymond F, Sayer AA, Ming Sim C, Slater-Jefferies J, Syddall HE, Fang Tan P, Titcombe P, Vaz C, Westbury LD, Wong G, Yonghui W, Cooper C, Sheppard A, Godfrey KM, Lillycrop KA, Karnani N, Feige JN. Migliavacca E, et al. Among authors: garratt es. Nat Commun. 2019 Dec 20;10(1):5808. doi: 10.1038/s41467-019-13694-1. Nat Commun. 2019. PMID: 31862890 Free PMC article.
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Among authors: garratt es. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.
Burton MA, Antoun E, Garratt ES, Westbury L, Baczynska A, Dennison EM, Harvey NC, Cooper C, Patel HP, Godfrey KM, Lillycrop KA; EpiGen Global Research Consortium. Burton MA, et al. Among authors: garratt es. J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1762-1774. doi: 10.1002/jcsm.13255. Epub 2023 May 18. J Cachexia Sarcopenia Muscle. 2023. PMID: 37199333 Free PMC article.
Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).
Antoun E, Garratt ES, Taddei A, Burton MA, Barton SJ, Titcombe P, Westbury LD, Baczynska A, Migliavacca E, Feige JN, Sydall HE, Dennison E, Dodds R, Roberts HC, Richardson P, Sayer AA, Shaw S, Cooper C, Holbrook JD, Patel HP, Godfrey KM, Lillycrop KA; EpiGen Global Research Consortium. Antoun E, et al. Among authors: garratt es. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):240-253. doi: 10.1002/jcsm.12876. Epub 2021 Dec 4. J Cachexia Sarcopenia Muscle. 2022. PMID: 34862756 Free PMC article.
DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake.
Antoun E, Titcombe P, Dalrymple K, Kitaba NT, Barton SJ, Flynn A, Murray R, Garratt ES, Seed PT, White SL, Cooper C, Inskip HM, Hanson M, Poston L, Godfrey KM, Lillycrop KA; UPBEAT Consortium/EpiGen Consortium. Antoun E, et al. Among authors: garratt es. Epigenetics. 2022 Apr;17(4):405-421. doi: 10.1080/15592294.2021.1908706. Epub 2021 Apr 28. Epigenetics. 2022. PMID: 33784941 Free PMC article.
Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.
Lillycrop KA, Garratt ES, Titcombe P, Melton PE, Murray RJS, Barton SJ, Clarke-Harris R, Costello PM, Holbrook JD, Hopkins JC, Childs CE, Paras-Chavez C, Calder PC, Mori TA, Beilin L, Burdge GC, Gluckman PD, Inskip HM, Harvey NC, Hanson MA, Huang RC, Cooper C; EpiGen Consortium; Godfrey KM. Lillycrop KA, et al. Among authors: garratt es. Int J Obes (Lond). 2019 May;43(5):974-988. doi: 10.1038/s41366-018-0254-3. Epub 2019 Jan 8. Int J Obes (Lond). 2019. PMID: 30622309 Free PMC article.
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.
Antoun E, Kitaba NT, Titcombe P, Dalrymple KV, Garratt ES, Barton SJ, Murray R, Seed PT, Holbrook JD, Kobor MS, Lin DT, MacIsaac JL, Burdge GC, White SL, Poston L, Godfrey KM, Lillycrop KA; UPBEAT Consortium. Antoun E, et al. Among authors: garratt es. PLoS Med. 2020 Nov 5;17(11):e1003229. doi: 10.1371/journal.pmed.1003229. eCollection 2020 Nov. PLoS Med. 2020. PMID: 33151971 Free PMC article. Clinical Trial.
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