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Gse1, a component of the CoREST complex, is required for placenta development in the mouse.
Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H, Takaoka K, Nishimura O, Kuraku S, Tanaka S, Hamada H. Hiver S, et al. Dev Biol. 2023 Jun;498:97-105. doi: 10.1016/j.ydbio.2023.03.009. Epub 2023 Apr 4. Dev Biol. 2023. PMID: 37019373
Here, we examined the expression and role of Gse1 in mouse development. Gse1 is expressed in male and female germ cells and plays both maternal and zygotic roles. ...Gse1 mutant (Gse1(deltaex3/deltaex3)) placenta begins to exhibit histological defects …
Here, we examined the expression and role of Gse1 in mouse development. Gse1 is expressed in male and female germ cells and pl …
GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage.
Vcelkova T, Reiter W, Zylka M, Hollenstein DM, Schuckert S, Hartl M, Seiser C. Vcelkova T, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11748-11769. doi: 10.1093/nar/gkad911. Nucleic Acids Res. 2023. PMID: 37878419 Free PMC article.
While loss of GSE1 does not affect the histone deacetylation activity of CoREST, GSE1 appears to be essential for binding of the deubiquitinase USP22 to CoREST and for the deubiquitination of H2B K120 in response to DNA damage. ...Since GSE1 has been previous …
While loss of GSE1 does not affect the histone deacetylation activity of CoREST, GSE1 appears to be essential for binding of t …
Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells.
Wang W, Wang S, Xu AM, Yuan X, Huang L, Li J. Wang W, et al. Biomed Res Int. 2021 Feb 2;2021:8834923. doi: 10.1155/2021/8834923. eCollection 2021. Biomed Res Int. 2021. PMID: 33623790 Free PMC article.
Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1) promoted trastuzumab resistance in HER2-positive gastric cancer cells. Acquired trastuzumab-resistant gastric cancer cells overexpresse …
Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1 …
GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion.
Chai P, Tian J, Zhao D, Zhang H, Cui J, Ding K, Liu B. Chai P, et al. Biochem Biophys Res Commun. 2016 Feb 26;471(1):123-8. doi: 10.1016/j.bbrc.2016.01.168. Epub 2016 Jan 30. Biochem Biophys Res Commun. 2016. PMID: 26828271
Gse1 coiled-coil protein (GSE1), also known as KIAA0182, is a proline rich protein. However, the function of GSE1 is largely unknown. In this study, we reported that GSE1 is overexpression in breast cancer and silencing of GSE1 significantly sup …
Gse1 coiled-coil protein (GSE1), also known as KIAA0182, is a proline rich protein. However, the function of GSE1 is la …
GSE1 predicts poor survival outcome in gastric cancer patients by SLC7A5 enhancement of tumor growth and metastasis.
Ding K, Tan S, Huang X, Wang X, Li X, Fan R, Zhu Y, Lobie PE, Wang W, Wu Z. Ding K, et al. J Biol Chem. 2018 Mar 16;293(11):3949-3964. doi: 10.1074/jbc.RA117.001103. Epub 2018 Jan 24. J Biol Chem. 2018. PMID: 29367342 Free PMC article.
The depletion of endogenous GSE1 with shRNAs decreased the oncogenicity and invasiveness of gastric cancer cells both in vitro and in vivo In addition, GSE1 was determined to be a direct target of miR-200b and miR-200c. ...GSE1 therefore possesses an oncogeni …
The depletion of endogenous GSE1 with shRNAs decreased the oncogenicity and invasiveness of gastric cancer cells both in vitro and in …
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML.
Nicosia L, Boffo FL, Ceccacci E, Conforti F, Pallavicini I, Bedin F, Ravasio R, Massignani E, Somervaille TCP, Minucci S, Bonaldi T. Nicosia L, et al. Oncogene. 2022 Feb;41(6):878-894. doi: 10.1038/s41388-021-02123-7. Epub 2021 Dec 3. Oncogene. 2022. PMID: 34862459 Free PMC article.
Mechanistically, we found that a set of genes associated with immune response and cytokine-signaling pathways are upregulated by LSD1 inhibitors through GSE1-protein reduction and that LSD1 and GSE1 colocalize at promoters of a subset of these genes at the basal sta …
Mechanistically, we found that a set of genes associated with immune response and cytokine-signaling pathways are upregulated by LSD1 inhibi …
Genetic Suppressor Element 1 (GSE1) Promotes the Oncogenic and Recurrent Phenotypes of Castration-Resistant Prostate Cancer by Targeting Tumor-Associated Calcium Signal Transducer 2 (TACSTD2).
Bamodu OA, Wang YH, Ho CH, Hu SW, Lin CD, Tzou KY, Wu WL, Chen KC, Wu CC. Bamodu OA, et al. Cancers (Basel). 2021 Aug 5;13(16):3959. doi: 10.3390/cancers13163959. Cancers (Basel). 2021. PMID: 34439112 Free PMC article.
OBJECTIVE: this study investigated the role of aberrantly expressed GSE1 in the metastasis, therapy resistance, relapse, and poor prognosis of advanced PCa. ...Patients with GSE1(high)TACSTD2(low) expression are more prone to recurrence and disease-specific death th …
OBJECTIVE: this study investigated the role of aberrantly expressed GSE1 in the metastasis, therapy resistance, relapse, and poor pro …
CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation.
Infante T, Pepin ME, Ruocco A, Trama U, Mauro C, Napoli C. Infante T, et al. Eur J Clin Invest. 2024 Mar;54(3):e14135. doi: 10.1111/eci.14135. Epub 2023 Nov 22. Eur J Clin Invest. 2024. PMID: 37991085
RESULTS: An atrial-specific PPI network revealed 18 hub differentially methylated genes (DMGs), wherein ROC curve analysis revealed reasonable diagnostic performance of DNA methylation levels found within CDK5R1 (AUC = 0.76; p = 0.049), HSPG2 (AUC = 0.77; p = 0.038), WDFY3 (AUC = …
RESULTS: An atrial-specific PPI network revealed 18 hub differentially methylated genes (DMGs), wherein ROC curve analysis revealed reasonab …
Circ_0001982 aggravates breast cancer development through the circ_0001982-miR-144-3p-GSE1 axis.
Gao F, Han J, Jia L, He J, Wang Y, Chen M. Gao F, et al. J Biochem Mol Toxicol. 2024 Jan;38(1):e23565. doi: 10.1002/jbt.23565. Epub 2023 Oct 23. J Biochem Mol Toxicol. 2024. PMID: 37867456
Circ_0001982 sponged miR-144-3p and negatively regulated miR-144-3p expression in BC cells. In addition, GSE1 was identified as a target mRNA of miR-144-3p. Ectopic GSE1 expression relieved circ_0001982 depletion-induced effects on BC cell tumor properties. ...Circ_ …
Circ_0001982 sponged miR-144-3p and negatively regulated miR-144-3p expression in BC cells. In addition, GSE1 was identified as a tar …
Characterization of gibberellin receptor mutants of barley (Hordeum vulgare L.).
Chandler PM, Harding CA, Ashton AR, Mulcair MD, Dixon NE, Mander LN. Chandler PM, et al. Mol Plant. 2008 Mar;1(2):285-94. doi: 10.1093/mp/ssn002. Epub 2008 Feb 11. Mol Plant. 2008. PMID: 19825540 Free article.
Its potential role in GA responses was investigated using barley mutants with reduced GA sensitivity (gse1 mutants). Sixteen different gse1 mutants each carried a unique nucleotide substitution in this sequence. ...There was perfect linkage in segregating population …
Its potential role in GA responses was investigated using barley mutants with reduced GA sensitivity (gse1 mutants). Sixteen differen …
50 results