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GPR17 receptor modulators and their therapeutic implications: review of recent patents.
Marucci G, Dal Ben D, Lambertucci C, Martí Navia A, Spinaci A, Volpini R, Buccioni M. Marucci G, et al. Expert Opin Ther Pat. 2019 Feb;29(2):85-95. doi: 10.1080/13543776.2019.1568990. Epub 2019 Jan 24. Expert Opin Ther Pat. 2019. PMID: 30640576 Review.
INTRODUCTION: The GPR17 receptor, phylogenetically related to both purinergic P2Y and CysLT receptors, is mainly expressed in the CNS and, in general, in organs that can typically undergo ischemic damage. ...In this work, information is reported about the representative st …
INTRODUCTION: The GPR17 receptor, phylogenetically related to both purinergic P2Y and CysLT receptors, is mainly expressed in the CNS …
Regulation and signaling of the GPR17 receptor in oligodendroglial cells.
Lecca D, Raffaele S, Abbracchio MP, Fumagalli M. Lecca D, et al. Glia. 2020 Oct;68(10):1957-1967. doi: 10.1002/glia.23807. Epub 2020 Feb 22. Glia. 2020. PMID: 32086854 Free article. Review.
We also highlight crucial insights into GPR17 pathophysiology coming from the demonstration that oligodendrocyte injury, associated with inflammation in chronic neurodegenerative conditions, is invariably characterized by abnormal and persistent GPR17 upregulation, …
We also highlight crucial insights into GPR17 pathophysiology coming from the demonstration that oligodendrocyte injury, associated w …
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice.
Liang Y, Kang X, Zhang H, Xu H, Wu X. Liang Y, et al. J Neuroinflammation. 2023 Nov 21;20(1):271. doi: 10.1186/s12974-023-02958-9. J Neuroinflammation. 2023. PMID: 37990234 Free PMC article.
BACKGROUND: Previously we reported that inhibition of GPR17 prevents amyloid beta 1-42 (Abeta(1-42))-induced cognitive impairment in mice. However, the role of GPR17 on cognition is still largely unknown. METHODS: Herein, we used a mouse model of cognitive impairmen …
BACKGROUND: Previously we reported that inhibition of GPR17 prevents amyloid beta 1-42 (Abeta(1-42))-induced cognitive impairment in …
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.
Wang J, He X, Meng H, Li Y, Dmitriev P, Tian F, Page JC, Lu QR, He Z. Wang J, et al. Neuron. 2020 Dec 9;108(5):876-886.e4. doi: 10.1016/j.neuron.2020.09.016. Epub 2020 Oct 26. Neuron. 2020. PMID: 33108748 Free PMC article.
In this study, we found that, in injured optic nerves, oligodendrocyte precursor cells (OPCs) undergo transient proliferation but fail to differentiate into mature myelination-competent oligodendrocytes, reminiscent of what is observed in human progressive multiple sclerosis. Mec …
In this study, we found that, in injured optic nerves, oligodendrocyte precursor cells (OPCs) undergo transient proliferation but fail to di …
The GPR17 Receptor-A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis.
Dziedzic A, Miller E, Saluk-Bijak J, Bijak M. Dziedzic A, et al. Int J Mol Sci. 2020 Mar 8;21(5):1852. doi: 10.3390/ijms21051852. Int J Mol Sci. 2020. PMID: 32182666 Free PMC article. Review.
The modulator of the central nervous system myelination is the metabotropic receptor coupled to the G-protein: GPR17. GPR17 receptors are considered to be sensors of local damage to the myelin sheath, and play a role in the reconstruction and repair of demyelinating …
The modulator of the central nervous system myelination is the metabotropic receptor coupled to the G-protein: GPR17. GPR17 re …
GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter.
Mao FX, Chen HJ, Qian LH, Buzby JS. Mao FX, et al. Brain Res Bull. 2020 Aug;161:33-42. doi: 10.1016/j.brainresbull.2020.04.019. Epub 2020 May 5. Brain Res Bull. 2020. PMID: 32387084
NG2(+)/GPR17(+)progenitor cells at 48 h-96 h and O4(+)/GPR17(+)precursor cells at 72h to 7d were also significantly increased in the PVL compared to the sham groups. ...The functional role of GPR17 in the intrinsic repair response to ischemia was tested using …
NG2(+)/GPR17(+)progenitor cells at 48 h-96 h and O4(+)/GPR17(+)precursor cells at 72h to 7d were also significantly increased …
Involvement of GPR17 in Neuronal Fibre Outgrowth.
Braune M, Scherf N, Heine C, Sygnecka K, Pillaiyar T, Parravicini C, Heimrich B, Abbracchio MP, Müller CE, Franke H. Braune M, et al. Int J Mol Sci. 2021 Oct 28;22(21):11683. doi: 10.3390/ijms222111683. Int J Mol Sci. 2021. PMID: 34769111 Free PMC article.
Immunofluorescence labelling showed a marked expression of GPR17 on NG2-positive glia. Western blot and RT-qPCR analysis of untreated cultures suggest a time-dependent, injury-induced stimulation of GPR17. In conclusion, MTK was identified as a stimulator of neurite …
Immunofluorescence labelling showed a marked expression of GPR17 on NG2-positive glia. Western blot and RT-qPCR analysis of untreated …
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Yan S, Conley JM, Reilly AM, Stull ND, Abhyankar SD, Ericsson AC, Kono T, Molosh AI, Kubal CA, Evans-Molina C, Ren H. Yan S, et al. Cell Rep. 2022 Jan 4;38(1):110179. doi: 10.1016/j.celrep.2021.110179. Cell Rep. 2022. PMID: 34986353 Free PMC article.
Acute genetic ablation of Gpr17 in intestinal epithelium improves glucose tolerance and glucose-stimulated insulin secretion (GSIS). ...Together, our work shows that intestinal Gpr17 signaling functions as an inhibitory pathway for GLP-1 secretion in EECs, suggestin …
Acute genetic ablation of Gpr17 in intestinal epithelium improves glucose tolerance and glucose-stimulated insulin secretion (GSIS). …
Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles.
Conley JM, Sun H, Ayers KL, Zhu H, Chen R, Shen M, Hall MD, Ren H. Conley JM, et al. J Biol Chem. 2021 Jul;297(1):100881. doi: 10.1016/j.jbc.2021.100881. Epub 2021 Jun 16. J Biol Chem. 2021. PMID: 34144038 Free PMC article.
These nine GPR17 variants had similar protein expression and subcellular localization as wild-type GPR17; however, they showed diverse downstream signaling profiles. ...GPR17-V96M retained cAMP inhibition similar to GPR17-WT, but showed impaired Ca(2+) …
These nine GPR17 variants had similar protein expression and subcellular localization as wild-type GPR17; however, they showed …
Inhibition of GPR17/ID2 Axis Improve Remyelination and Cognitive Recovery after SAH by Mediating OPC Differentiation in Rat Model.
Wang Y, Jiang A, Yan J, Wen D, Gu N, Li Z, Sun X, Wu Y, Guo Z. Wang Y, et al. Transl Stroke Res. 2023 Nov 7. doi: 10.1007/s12975-023-01201-0. Online ahead of print. Transl Stroke Res. 2023. PMID: 37935878
Moreover, GPR17 knockdown attenuated the elevated expression of the inhibitor of DNA binding 2 (ID2) post-SAH, suggesting a GPR17-ID2 regulatory axis. ...This study positions GPR17 as a potential therapeutic target for SAH intervention. The interplay between …
Moreover, GPR17 knockdown attenuated the elevated expression of the inhibitor of DNA binding 2 (ID2) post-SAH, suggesting a GPR17 …
188 results