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Novel GPR156 variants confirm its role in moderate sensorineural hearing loss.
Ramzan M, Bozan N, Seyhan S, Zafeer MF, Ayral A, Duman D, Bademci G, Tekin M. Ramzan M, et al. Sci Rep. 2023 Oct 9;13(1):17010. doi: 10.1038/s41598-023-44259-4. Sci Rep. 2023. PMID: 37814107 Free PMC article.
The data analysis identified the c.600G > A (p.Thr200Thr) and c.1863dupG (p.His622fs) variants in GPR156, which co-segregated with the phenotype as an autosomal recessive trait in the respective families. ...This gene belongs to the family of G protein-coupled receptors …
The data analysis identified the c.600G > A (p.Thr200Thr) and c.1863dupG (p.His622fs) variants in GPR156, which co-segregated with …
EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia.
Kindt KS, Akturk A, Jarysta A, Day M, Beirl A, Flonard M, Tarchini B. Kindt KS, et al. Nat Commun. 2021 May 17;12(1):2861. doi: 10.1038/s41467-021-22997-1. Nat Commun. 2021. PMID: 34001891 Free PMC article.
Remarkably, GPR156-Galphai also instructs hair cell reversal in the auditory epithelium, despite a lack of mirror-image organization. Overall, our work demonstrates that conserved GPR156-Galphai signaling is integral to the framework that builds directional response …
Remarkably, GPR156-Galphai also instructs hair cell reversal in the auditory epithelium, despite a lack of mirror-image organization. …
Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence.
Kalam H, Chou CH, Kadoki M, Graham DB, Deguine J, Hung DT, Xavier RJ. Kalam H, et al. Cell Host Microbe. 2023 Jun 14;31(6):978-992.e5. doi: 10.1016/j.chom.2023.05.009. Epub 2023 Jun 2. Cell Host Microbe. 2023. PMID: 37269834
Targeting triacylglycerol synthesis reduced both droplet formation and Mtb persistence. The orphan G protein-coupled receptor GPR156 is a key inducer of droplet accumulation in deltaMMGT1 cells. Our work uncovers the role of MMGT1-GPR156-lipid droplets in the induct …
Targeting triacylglycerol synthesis reduced both droplet formation and Mtb persistence. The orphan G protein-coupled receptor GPR156 …
Genetic association analysis of 77,539 genomes reveals rare disease etiologies.
Greene D; Genomics England Research Consortium; Pirri D, Frudd K, Sackey E, Al-Owain M, Giese APJ, Ramzan K, Riaz S, Yamanaka I, Boeckx N, Thys C, Gelb BD, Brennan P, Hartill V, Harvengt J, Kosho T, Mansour S, Masuno M, Ohata T, Stewart H, Taibah K, Turner CLS, Imtiaz F, Riazuddin S, Morisaki T, Ostergaard P, Loeys BL, Morisaki H, Ahmed ZM, Birdsey GM, Freson K, Mumford A, Turro E. Greene D, et al. Nat Med. 2023 Mar;29(3):679-688. doi: 10.1038/s41591-023-02211-z. Epub 2023 Mar 16. Nat Med. 2023. PMID: 36928819 Free PMC article.
We identified 241 known and 19 previously unidentified associations. We validated associations with ERG, PMEPA1 and GPR156 by searching for pedigrees in other cohorts and using bioinformatic and experimental approaches. We provide evidence that (1) loss-of-function variant …
We identified 241 known and 19 previously unidentified associations. We validated associations with ERG, PMEPA1 and GPR156 by searchi …
In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity.
Watkins LR, Orlandi C. Watkins LR, et al. Br J Pharmacol. 2021 Aug;178(15):2963-2975. doi: 10.1111/bph.15468. Epub 2021 May 8. Br J Pharmacol. 2021. PMID: 33784795 Free article.
Excitingly, this approach illuminated the G protein coupling profile of eight orphan GPCRs (GPR22, GPR137b, GPR88, GPR156, GPR158, GPR179, GPRC5D and GPRC6A) previously linked to pathophysiological processes. ...
Excitingly, this approach illuminated the G protein coupling profile of eight orphan GPCRs (GPR22, GPR137b, GPR88, GPR156, GPR158, GP …
Constitutive activation mechanism of a class C GPCR.
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y. Shin J, et al. Nat Struct Mol Biol. 2024 Apr;31(4):678-687. doi: 10.1038/s41594-024-01224-7. Epub 2024 Feb 8. Nat Struct Mol Biol. 2024. PMID: 38332368
Impaired GPR156-G(i) signaling contributes to loss of hearing. Here we present the cryo-electron microscopy structures of human GPR156 in the G(o)-free and G(o)-coupled states. ...Our findings reveal that GPR156 is a transducer for phospholipid signaling. Con …
Impaired GPR156-G(i) signaling contributes to loss of hearing. Here we present the cryo-electron microscopy structures of human GP …
Hear the sounds: the role of G protein-coupled receptors in the cochlea.
Zhang Z, Chai R. Zhang Z, et al. Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1088-C1099. doi: 10.1152/ajpcell.00453.2021. Epub 2022 Aug 8. Am J Physiol Cell Physiol. 2022. PMID: 35938679 Free article. Review.
In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and Gpr126. And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss. ...
In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and Gpr126. And A1, A2A, and CB2 …
The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.
Jia S, Ratzan EM, Goodrich EJ, Abrar R, Heiland L, Tarchini B, Deans MR. Jia S, et al. Elife. 2023 May 5;12:e84910. doi: 10.7554/eLife.84910. Elife. 2023. PMID: 37144879 Free PMC article.
The transcription factor EMX2 is known to establish this planar polarized organization in mouse by regulating the distribution of the transmembrane receptor GPR156 at hair cell boundaries in one group of cells. However, the genes regulated by EMX2 in this context were prev …
The transcription factor EMX2 is known to establish this planar polarized organization in mouse by regulating the distribution of the transm …
Age-associated changes in gene expression in the anterior pituitary glands of female Japanese black cattle.
Abdillah DA, Kereilwe O, Mizukami Y, Watanabe K, Kadokawa H. Abdillah DA, et al. Mamm Genome. 2022 Dec;33(4):606-618. doi: 10.1007/s00335-022-09958-9. Epub 2022 Jul 15. Mamm Genome. 2022. PMID: 35838775
The DEGs included 1 cytokine (AIMP1), 3 growth factors (NRG2, PTN, and TGFB1), 1 receptor-associated protein gene (AGTRAP), and 10 receptor genes, including PRLHR and two orphan G-protein-coupled receptors (GPR156 and GPR176). Metascape analysis of the DEGs revealed "Pepti …
The DEGs included 1 cytokine (AIMP1), 3 growth factors (NRG2, PTN, and TGFB1), 1 receptor-associated protein gene (AGTRAP), and 10 receptor …
Decoding pathogenesis factors involved in the progression of ATLL or HAM/TSP after infection by HTLV-1 through a systems virology study.
Zarei Ghobadi M, Emamzadeh R, Teymoori-Rad M, Mozhgani SH. Zarei Ghobadi M, et al. Virol J. 2021 Aug 26;18(1):175. doi: 10.1186/s12985-021-01643-8. Virol J. 2021. PMID: 34446027 Free PMC article.
Eventually, the final analysis revealed the involvement of specific dysregulated genes including KIRREL2, RAB36, and KANK1 in HAM/TSP as well as LTB4R2, HCN4, FZD9, GRIK5, CREB3L4, TACR2, FRMD1, LHB, FGF3, TEAD3, GRIN2D, GNRH2, PRLH, GPR156, and CRHR2 in ATLL. CONCLUSION: …
Eventually, the final analysis revealed the involvement of specific dysregulated genes including KIRREL2, RAB36, and KANK1 in HAM/TSP as wel …