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Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network.
Sengupta D, Truschel S, Bachert C, Linstedt AD. Sengupta D, et al. J Cell Biol. 2009 Jul 13;186(1):41-55. doi: 10.1083/jcb.200902110. Epub 2009 Jul 6. J Cell Biol. 2009. PMID: 19581411 Free PMC article.
Mitochondria bearing GRASP65 became tethered to one another, and this depended on a GRASP65 PDZ domain that was also required for GRASP65 self-interaction. Point mutation within the predicted binding groove of the GRASP65 PDZ domain blocked both tethering and, in a gene re …
Mitochondria bearing GRASP65 became tethered to one another, and this depended on a GRASP65 PDZ domain that was also required for GRASP65 se …
Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand.
Sengupta D, Linstedt AD. Sengupta D, et al. J Biol Chem. 2010 Dec 17;285(51):39994-40003. doi: 10.1074/jbc.M110.189449. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937827 Free PMC article.
Further, using interaction assays, we discovered an internal PDZ ligand adjacent to the PLK phosphorylation site that was required for tethering. These results reveal the mechanism of phosphoinhibition as direct inhibition by PLK1 of the PDZ ligand underlying the GR …
Further, using interaction assays, we discovered an internal PDZ ligand adjacent to the PLK phosphorylation site that was required fo …
Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis.
Cheng JP, Betin VM, Weir H, Shelmani GM, Moss DK, Lane JD. Cheng JP, et al. Cell Death Dis. 2010 Oct 7;1(10):e82. doi: 10.1038/cddis.2010.59. Cell Death Dis. 2010. PMID: 21368855 Free PMC article.
Instead, we find that the C-terminal fragments of GRASP65 produced following caspase cleavage are targeted to mitochondria, and ectopic expression of these sensitises HeLa cells to Fas ligand. Our data suggest that GRASP65 cleavage promotes Fas/CD95-mediated apoptosis via …
Instead, we find that the C-terminal fragments of GRASP65 produced following caspase cleavage are targeted to mitochondria, and ectopic expr …