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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1981 1
1982 1
1984 1
1985 2
1987 1
1988 1
1989 2
1992 1
1993 2
1994 2
1995 1
1996 1
1997 6
1998 3
2000 3
2001 3
2002 4
2003 11
2004 5
2005 6
2006 8
2007 7
2008 12
2009 13
2010 10
2011 15
2012 17
2013 17
2014 13
2015 16
2016 16
2017 9
2018 15
2019 17
2020 12
2021 20
2022 15
2023 19
2024 4

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286 results

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Page 1
Glycine and aging: Evidence and mechanisms.
Johnson AA, Cuellar TL. Johnson AA, et al. Ageing Res Rev. 2023 Jun;87:101922. doi: 10.1016/j.arr.2023.101922. Epub 2023 Mar 31. Ageing Res Rev. 2023. PMID: 37004845 Free article. Review.
In flies, Gnmt is required for reduced insulin/insulin-like growth factor 1 signaling and dietary restriction to fully extend lifespan. The geroprotector spermidine requires Gnmt to upregulate autophagy genes and boost longevity. Moreover, the overexpression of G …
In flies, Gnmt is required for reduced insulin/insulin-like growth factor 1 signaling and dietary restriction to fully extend lifespa …
The multi-functional roles of GNMT in toxicology and cancer.
Yen CH, Lin YT, Chen HL, Chen SY, Chen YM. Yen CH, et al. Toxicol Appl Pharmacol. 2013 Jan 1;266(1):67-75. doi: 10.1016/j.taap.2012.11.003. Epub 2012 Nov 10. Toxicol Appl Pharmacol. 2013. PMID: 23147572 Review.
Although glycine N-methyltransferase (GNMT) has been discovered for five decades, its function was not elucidated until recently. ...In terms of cancer, recent studies using GNMT knockout mouse models demonstrated that GNMT deficiency has high penetrance in i …
Although glycine N-methyltransferase (GNMT) has been discovered for five decades, its function was not elucidated until recently. ... …
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.
Wang YC, Chen YM, Lin YJ, Liu SP, Chiang EP. Wang YC, et al. Mol Med. 2011 May-Jun;17(5-6):486-94. doi: 10.2119/molmed.2010.00243. Epub 2011 Jan 3. Mol Med. 2011. PMID: 21210071 Free PMC article.
GNMT-diminished hepatoma cell lines transfected with GNMT were cultured under folate abundance or restriction. ...In the mouse models, GNMT(tg) had increased hepatic folate significantly, whereas GNMT(ko) had reduced folate. ...
GNMT-diminished hepatoma cell lines transfected with GNMT were cultured under folate abundance or restriction. ...In the mouse …
S-adenosylmethionine in liver health, injury, and cancer.
Lu SC, Mato JM. Lu SC, et al. Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011. Physiol Rev. 2012. PMID: 23073625 Free PMC article. Review.
This can result from inactive mutation of the enzyme glycine N-methyltransferase (GNMT). Children with GNMT mutation have elevated liver transaminases, and Gnmt knockout mice develop liver injury, fibrosis, and HCC. ...
This can result from inactive mutation of the enzyme glycine N-methyltransferase (GNMT). Children with GNMT mutation have elev …
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.
Kant R, Yen CH, Hung JH, Lu CK, Tung CY, Chang PC, Chen YH, Tyan YC, Chen YA. Kant R, et al. Sci Rep. 2019 Feb 13;9(1):1968. doi: 10.1038/s41598-018-37292-1. Sci Rep. 2019. PMID: 30760754 Free PMC article.
Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC. In this study, we aimed to delineate the mechanism by which PGG enhances GNMT expression and to investigate its effect on GNMT suppress …
Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC. In this s …
The Case for GNMT as a Biomarker and a Therapeutic Target in Pancreatic Cancer.
Heinzman Z, Schmidt C, Sliwinski MK, Goonesekere NCW. Heinzman Z, et al. Pharmaceuticals (Basel). 2021 Mar 3;14(3):209. doi: 10.3390/ph14030209. Pharmaceuticals (Basel). 2021. PMID: 33802396 Free PMC article.
Similar results are observed in early-stage patient tissue samples, where GNMT expression can be reduced by a 100-fold or more. We also show that PGG is a strong inhibitor of PC cell proliferation, with an IC(50) value of 12 ng/mL, and PGG upregulates GNMT expressio …
Similar results are observed in early-stage patient tissue samples, where GNMT expression can be reduced by a 100-fold or more. We al …
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML. Fernández-Tussy P, et al. Mol Metab. 2019 Nov;29:40-54. doi: 10.1016/j.molmet.2019.08.008. Epub 2019 Aug 16. Mol Metab. 2019. PMID: 31668391 Free PMC article.
We have studied the mechanism involved in GNMT downregulation by its repressor microRNA miR-873-5p and the metabolic pathways affected in NAFLD as well as the benefit of recovery GNMT expression. METHODS: miR-873-5p and GNMT expression were evaluated in liver …
We have studied the mechanism involved in GNMT downregulation by its repressor microRNA miR-873-5p and the metabolic pathways affecte …
ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production.
Kishi S, Mori S, Fujiwara-Tani R, Ogata R, Sasaki R, Ikemoto A, Goto K, Sasaki T, Miyake M, Sasagawa S, Kawaichi M, Luo Y, Bhawal UK, Fujimoto K, Nakagawa H, Kuniyasu H. Kishi S, et al. Int J Mol Sci. 2023 Nov 15;24(22):16367. doi: 10.3390/ijms242216367. Int J Mol Sci. 2023. PMID: 38003554 Free PMC article.
In contrast, RT4 cells derived from non-invasive cancers expressed low GNMT, and SAM treatment did not produce sarcosine and did not promote malignant phenotypes. In T24 cells, the expression of miR-873-5p, which suppresses GNMT expression, was suppressed, and the e …
In contrast, RT4 cells derived from non-invasive cancers expressed low GNMT, and SAM treatment did not produce sarcosine and did not …
Chemical Biopsy for GNMT as Noninvasive and Tumorigenesis-Relevant Diagnosis of Liver Cancer.
Oh S, Jo S, Kim HS, Mai VH, Endaya B, Neuzil J, Jung KH, Hong SS, Kim JM, Park S. Oh S, et al. Anal Chem. 2023 Jan 17;95(2):1184-1192. doi: 10.1021/acs.analchem.2c03944. Epub 2023 Jan 5. Anal Chem. 2023. PMID: 36602057
Bioinformatic screening for tumor suppressors yielded glycine N-methyltransferase (GNMT) as a biomarker with clinical relevance to HCC tumorigenesis. A liquid chromatography-mass spectrometry (LC-MS)-based chemical biopsy detecting nonradioactive (13)C-sarcosine from (13)C …
Bioinformatic screening for tumor suppressors yielded glycine N-methyltransferase (GNMT) as a biomarker with clinical relevance to HC …
286 results