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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2012 1
2013 1
2014 4
2015 4
2016 7
2017 4
2018 1
2019 1
2020 3
2021 8
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2023 4
2024 1

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Page 1
The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer.
Hodgson K, Orozco-Moreno M, Scott E, Garnham R, Livermore K, Thomas H, Zhou Y, He J, Bermudez A, Garcia Marques FJ, Bastian K, Hysenaj G, Archer Goode E, Heer R, Pitteri S, Wang N, Elliott DJ, Munkley J. Hodgson K, et al. Sci Rep. 2023 Oct 9;13(1):17031. doi: 10.1038/s41598-023-43019-8. Sci Rep. 2023. PMID: 37813880 Free PMC article.
Using in vitro and in vivo models, we show GCNT1 promotes the growth of prostate tumours and can modify the glycome of prostate cancer cells, including upregulation of core 2 O-glycans and modifying the O-glycosylation of secreted glycoproteins. Furthermore, using RNA sequ …
Using in vitro and in vivo models, we show GCNT1 promotes the growth of prostate tumours and can modify the glycome of prostate cance …
GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells.
Perkey E, Maurice De Sousa D, Carrington L, Chung J, Dils A, Granadier D, Koch U, Radtke F, Ludewig B, Blazar BR, Siebel CW, Brennan TV, Nolz J, Labrecque N, Maillard I. Perkey E, et al. J Immunol. 2020 Mar 15;204(6):1674-1688. doi: 10.4049/jimmunol.1901194. Epub 2020 Feb 14. J Immunol. 2020. PMID: 32060138 Free PMC article.
In this study, we show that Notch signals induce upregulated expression of the Gcnt1 glycosyltransferase gene in T cells mediating graft-versus-host disease after allogeneic bone marrow transplantation in mice. To determine if Gcnt1-mediated O-glycosylation could be …
In this study, we show that Notch signals induce upregulated expression of the Gcnt1 glycosyltransferase gene in T cells mediating gr …
Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.
Fonseca KL, Maceiras AR, Matos R, Simoes-Costa L, Sousa J, Cá B, Barros L, Fernandes AI, Mereiter S, Reis R, Gomes J, Tapia G, Rodríguez-Martínez P, Martín-Céspedes M, Vashakidze S, Gogishvili S, Nikolaishvili K, Appelberg R, Gärtner F, Rodrigues PNS, Vilaplana C, Reis CA, Magalhães A, Saraiva M. Fonseca KL, et al. Mucosal Immunol. 2020 Sep;13(5):836-848. doi: 10.1038/s41385-020-0277-7. Epub 2020 Mar 13. Mucosal Immunol. 2020. PMID: 32203062 Free PMC article.
The increased susceptibility of Gcnt1 deficient mice was characterized by extensive lung immune pathology, mechanistically related to neutrophils. Uninfected Gcnt1 deficient mice presented bone marrow, blood and lung neutrophilia, which further increased with infect …
The increased susceptibility of Gcnt1 deficient mice was characterized by extensive lung immune pathology, mechanistically related to …
Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers.
Chen Z, Gulzar ZG, St Hill CA, Walcheck B, Brooks JD. Chen Z, et al. Prostate. 2014 Jul;74(10):1059-67. doi: 10.1002/pros.22826. Epub 2014 May 22. Prostate. 2014. PMID: 24854630 Free PMC article.
RESULTS: A key glycosyltransferase, GCNT1, was consistently over-expressed in several prostate cancer gene expression datasets. ...MUC1, PSA and PAP protein levels alone were not significantly different between paired normal and malignant prostate samples. CONCLUSIONS: …
RESULTS: A key glycosyltransferase, GCNT1, was consistently over-expressed in several prostate cancer gene expression datasets. ...MU …
Core 2 β-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness.
Sato T, Yoneyama T, Tobisawa Y, Hatakeyama S, Yamamoto H, Kojima Y, Mikami J, Mori K, Hashimoto Y, Koie T, Ohyama C. Sato T, et al. Biochem Biophys Res Commun. 2016 Jan 29;470(1):150-156. doi: 10.1016/j.bbrc.2016.01.011. Epub 2016 Jan 6. Biochem Biophys Res Commun. 2016. PMID: 26768364
We also examined the role of GCNT1 in PCa progression using cell lines which express high or low levels of GCNT1. ...GCNT1-negative tumors were associated with significantly better prostate-specific antigen (PSA)-free survival compared with GCNT1-posit …
We also examined the role of GCNT1 in PCa progression using cell lines which express high or low levels of GCNT1. ...GCNT1 …
Glycosylation is a global target for androgen control in prostate cancer cells.
Munkley J. Munkley J. Endocr Relat Cancer. 2017 Mar;24(3):R49-R64. doi: 10.1530/ERC-16-0569. Epub 2017 Feb 3. Endocr Relat Cancer. 2017. PMID: 28159857 Review.
We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly upregulated in pr …
We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosy …
Detection of Core2 β-1,6-N-Acetylglucosaminyltransferase in Post-Digital Rectal Examination Urine Is a Reliable Indicator for Extracapsular Extension of Prostate Cancer.
Kojima Y, Yoneyama T, Hatakeyama S, Mikami J, Sato T, Mori K, Hashimoto Y, Koie T, Ohyama C, Fukuda M, Tobisawa Y. Kojima Y, et al. PLoS One. 2015 Sep 21;10(9):e0138520. doi: 10.1371/journal.pone.0138520. eCollection 2015. PLoS One. 2015. PMID: 26390303 Free PMC article.
Paraffin-embedded PCa specimens were analyzed by immunohistochemistry for GCNT1 expression using a newly established mouse anti-GCNT1 mAb by ourselves. ...GCNT1-negative tumors were associated with significantly better prostate-specific antigen (PSA)-free sur …
Paraffin-embedded PCa specimens were analyzed by immunohistochemistry for GCNT1 expression using a newly established mouse anti-GC …
Transcriptome-wide association study of circulating IgE levels identifies novel targets for asthma and allergic diseases.
Recto KA, Huan T, Lee DH, Lee GY, Gereige J, Yao C, Hwang SJ, Joehanes R, Kelly RS, Lasky-Su J, O'Connor G, Levy D. Recto KA, et al. Front Immunol. 2023 Jan 30;14:1080071. doi: 10.3389/fimmu.2023.1080071. eCollection 2023. Front Immunol. 2023. PMID: 36793728 Free PMC article.
Mendelian randomization (MR) analysis revealed four genes (CLC, CCDC21, S100A13, and GCNT1) as putatively causal (p<0.05) regulators of IgE levels. GCNT1 (beta=1.5, p=0.01)-which is a top result in the MR analysis of expression in relation to asthma and allergic …
Mendelian randomization (MR) analysis revealed four genes (CLC, CCDC21, S100A13, and GCNT1) as putatively causal (p<0.05) regulato …
Core 2 ß1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1.
Mardahl M, Schröter MF, Engelbert D, Pink M, Sperandio M, Hamann A, Syrbe U. Mardahl M, et al. Mol Immunol. 2016 Sep;77:132-40. doi: 10.1016/j.molimm.2016.08.001. Epub 2016 Aug 6. Mol Immunol. 2016. PMID: 27505708
To understand the molecular regulation of Gcnt1 in CD4(+) T helper cells, we performed ChIP-on-chip experiments across the Gcnt1 locus assessing the chromatin structure in P-lig-expressing versus non-expressing CD4(+) T cells. This identified a distal region about 2 …
To understand the molecular regulation of Gcnt1 in CD4(+) T helper cells, we performed ChIP-on-chip experiments across the Gcnt1 …
[Development and Clinical Application of Glycan-Targeted Biomarkers for Prostate Cancer].
Ohyama C, Yoneyama T, Tobisawa Y, Ishikawa T, Hatakeyama S, Koie T, Mori K. Ohyama C, et al. Rinsho Byori. 2017 Feb;65(2):210-217. Rinsho Byori. 2017. PMID: 30762989 Japanese.
We established a mouse IgG monoclonal antibody (mAb) against GCNT1 and examined the relationship of GCNT1 expression with the clinicopathological status of PCa. GCNT1- negative patients were associated with significantly better PSA-free survival compared with …
We established a mouse IgG monoclonal antibody (mAb) against GCNT1 and examined the relationship of GCNT1 expression with the …
40 results