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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
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2008 1
2012 1
2013 1
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2020 3
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Page 1
G2E3 attenuating replicative stress.
Schmidt F, Karnitz LM, Dobbelstein M. Schmidt F, et al. Aging (Albany NY). 2015 Aug;7(8):527-8. doi: 10.18632/aging.100784. Aging (Albany NY). 2015. PMID: 26298869 Free PMC article. No abstract available.
G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization.
Brooks WS, Banerjee S, Crawford DF. Brooks WS, et al. Exp Cell Res. 2007 Feb 15;313(4):665-76. doi: 10.1016/j.yexcr.2006.11.020. Epub 2006 Dec 14. Exp Cell Res. 2007. PMID: 17239372 Free PMC article.
G2E3 was originally described as a G2/M-specific gene with DNA damage responsive expression. ...Additionally, G2E3 contains a nucleolar localization signal (NoLS) in its amino terminus. ...
G2E3 was originally described as a G2/M-specific gene with DNA damage responsive expression. ...Additionally, G2E3 contains a …
G2E3 is a dual function ubiquitin ligase required for early embryonic development.
Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF. Brooks WS, et al. J Biol Chem. 2008 Aug 8;283(32):22304-15. doi: 10.1074/jbc.M803238200. Epub 2008 May 28. J Biol Chem. 2008. PMID: 18511420 Free PMC article.
G2E3 is a putative ubiquitin ligase (E3) identified in a microarray screen for mitotic regulatory proteins. ...Animals heterozygous for G2E3 inactivation are phenotypically normal with no overt change in development, growth, longevity, or fertility, whereas G2E3 …
G2E3 is a putative ubiquitin ligase (E3) identified in a microarray screen for mitotic regulatory proteins. ...Animals heterozygous f …
Obesity of G2e3 Knockout Mice Suggests That Obesity-Associated Variants Near Human G2E3 Decrease G2E3 Activity.
Powell DR, Doree DD, DaCosta CM, Platt KA, Hansen GM, van Sligtenhorst I, Ding ZM, Revelli JP, Brommage R. Powell DR, et al. Diabetes Metab Syndr Obes. 2020 Jul 27;13:2641-2652. doi: 10.2147/DMSO.S259546. eCollection 2020. Diabetes Metab Syndr Obes. 2020. PMID: 32801815 Free PMC article.
G2e3 KO mice were also glucose intolerant during an OGTT (P<0.05). ...CONCLUSION: Significant obesity and glucose intolerance were observed in G2e3, but not Prkd1, KO mice. The conservation of obesity genes between mice and humans strongly suggests that the obesi …
G2e3 KO mice were also glucose intolerant during an OGTT (P<0.05). ...CONCLUSION: Significant obesity and glucose intolerance were …
Comprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer.
Shen Y, Xue J, Yu J, Jiang Y, Bu J, Zhu T, Gu X, Zhu X. Shen Y, et al. World J Surg Oncol. 2022 Dec 15;20(1):398. doi: 10.1186/s12957-022-02871-0. World J Surg Oncol. 2022. PMID: 36517818 Free PMC article.
BACKGROUND: Loss of G2-specific E3-like (G2E3) protein sensitizes tumor cells to chemotherapy. However, the role of G2E3 in breast cancer development and patient's prognosis is unclear. ...The Kaplan-Meier plotter database suggested that patients with high G2E3 …
BACKGROUND: Loss of G2-specific E3-like (G2E3) protein sensitizes tumor cells to chemotherapy. However, the role of G2E3 in br …
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease.
Zeng R, Wang J, Jiang R, Yang J, Zheng C, Wu H, Zhuo Z, Yang Q, Li J, Leung FW, Sha W, Chen H. Zeng R, et al. Aging Dis. 2023 Aug 1;14(4):1349-1359. doi: 10.14336/AD.2022.12209. Aging Dis. 2023. PMID: 37163440 Free PMC article.
Two shared genetic loci (rs6571361 and rs7154847) were derived, and SCFD1, G2E3, and HEATR5A were further identified as novel risk genes with enriched functions related to membrane trafficking. G2E3 was differentially expressed and significantly correlated with SCFD …
Two shared genetic loci (rs6571361 and rs7154847) were derived, and SCFD1, G2E3, and HEATR5A were further identified as novel risk ge …
Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells.
Schmidt F, Kunze M, Loock AC, Dobbelstein M. Schmidt F, et al. Oncotarget. 2015 Jan 20;6(2):617-32. doi: 10.18632/oncotarget.2710. Oncotarget. 2015. PMID: 25593194 Free PMC article.
Among known mediators of DDR, the screen identified the ubiquitin ligase G2E3 as a new player in the response to cisplatin. G2E3 depletion led to decreased gammaH2AX levels and decreased phosphorylation of the checkpoint kinase 1 (Chk1) upon cisplatin. Moreover, los …
Among known mediators of DDR, the screen identified the ubiquitin ligase G2E3 as a new player in the response to cisplatin. G2E3 …
High-Throughput Screening of Mouse Gene Knockouts Identifies Established and Novel High Body Fat Phenotypes.
Powell DR, Revelli JP, Doree DD, DaCosta CM, Desai U, Shadoan MK, Rodriguez L, Mullens M, Yang QM, Ding ZM, Kirkpatrick LL, Vogel P, Zambrowicz B, Sands AT, Platt KA, Hansen GM, Brommage R. Powell DR, et al. Diabetes Metab Syndr Obes. 2021 Aug 28;14:3753-3785. doi: 10.2147/DMSO.S322083. eCollection 2021. Diabetes Metab Syndr Obes. 2021. PMID: 34483672 Free PMC article.
Of 46 KO lines where independent external published and/or IMPC KO lines are reported as obese, 43 had increased body fat. For the remaining 29 novel high body fat KO lines, Ksr2 and G2e3 are supported by data from additional independent KO cohorts, 6 (Asnsd1, Srpk2, Dpp8, …
Of 46 KO lines where independent external published and/or IMPC KO lines are reported as obese, 43 had increased body fat. For the remaining …
Genome-wide Meta-analysis Identifies Novel Genes Associated with Recurrence and Progression in Non-muscle-invasive Bladder Cancer.
Galesloot TE, Grotenhuis AJ, Kolev D, Aben KK, Bryan RT, Catto JWF, Cheng KK, Conroy S, Dyrskjøt L, Fleshner NE, James ND, Lamy P, Lindskrog SV, Malats N, Mengual L, Verhaegh G, Zeegers MP, Kiemeney LALM, Vermeulen SH. Galesloot TE, et al. Eur Urol Oncol. 2022 Feb;5(1):70-83. doi: 10.1016/j.euo.2021.07.001. Epub 2021 Aug 2. Eur Urol Oncol. 2022. PMID: 34353775 Free article.
RESULTS AND LIMITATIONS: This meta-analysis revealed a genome-wide significant locus for RFS on chromosome 14 (lead SNP rs12885353, hazard ratio [HR] C vs T allele 1.55, 95% confidence interval [CI] 1.33-1.82, p = 4.0 10(-8)), containing genes G2E3 and SCFD1. Higher expres …
RESULTS AND LIMITATIONS: This meta-analysis revealed a genome-wide significant locus for RFS on chromosome 14 (lead SNP rs12885353, hazard r …
25 results