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221 results

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FOXQ1 promotes pancreatic cancer cell proliferation, tumor stemness, invasion and metastasis through regulation of LDHA-mediated aerobic glycolysis.
Wu C, Zheng C, Chen S, He Z, Hua H, Sun C, Yu C. Wu C, et al. Cell Death Dis. 2023 Oct 24;14(10):699. doi: 10.1038/s41419-023-06207-y. Cell Death Dis. 2023. PMID: 37875474 Free PMC article.
However, its function in PC is unknown. In our work, the expression of FOXQ1 was elevated in PC tissues, and a high level of FOXQ1 in PC was linked to patients' poor prognosis. ...Therefore, these novel data suggest that FOXQ1 may be a possible therapeutic ta …
However, its function in PC is unknown. In our work, the expression of FOXQ1 was elevated in PC tissues, and a high level of FOXQ1 …
FOXQ1 inhibits breast cancer ferroptosis and progression via the circ_0000643/miR-153/SLC7A11 axis.
Huang X, Wu J, Wang Y, Xian Z, Li J, Qiu N, Li H. Huang X, et al. Exp Cell Res. 2023 Oct 1;431(1):113737. doi: 10.1016/j.yexcr.2023.113737. Epub 2023 Aug 15. Exp Cell Res. 2023. PMID: 37591453
However, the specific effects of FOXQ1 on ferroptosis in breast cancer is unclear. In this study, we intended to explore the functions and potential mechanisms of FOXQ1 in breast cancer ferroptosis. ...We found that FOXQ1 was overexpressed in breast cancer an …
However, the specific effects of FOXQ1 on ferroptosis in breast cancer is unclear. In this study, we intended to explore the function …
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis.
Mitchell AV, Wu L, James Block C, Zhang M, Hackett J, Craig DB, Chen W, Zhao Y, Zhang B, Dang Y, Zhang X, Zhang S, Wang C, Gibson H, Pile LA, Kidder B, Matherly L, Yang Z, Dou Y, Wu G. Mitchell AV, et al. Nat Commun. 2022 Nov 1;13(1):6548. doi: 10.1038/s41467-022-34239-z. Nat Commun. 2022. PMID: 36319643 Free PMC article.
However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the MLL/KMT2 histone methyltransferase complex as a transcriptional coactivator. ...Moreover, genetic disruption of the FOXQ1-RbBP5 interac …
However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the ML …
FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival.
Elian FA, Are U, Ghosh S, Nuin P, Footz T, McMullen TPW, Brindley DN, Walter MA. Elian FA, et al. Breast Cancer (Dove Med Press). 2021 Mar 1;13:171-188. doi: 10.2147/BCTT.S282860. eCollection 2021. Breast Cancer (Dove Med Press). 2021. PMID: 33688250 Free PMC article.
Furthermore, analysis of BC cell lines showed that FOXQ1 mRNA expression was independent of CNV. Moreover, patients with low FOXQ1 mRNA expression had significantly poorer overall survival compared to those with high FOXQ1 mRNA expression. ...CONCLUSION: Our …
Furthermore, analysis of BC cell lines showed that FOXQ1 mRNA expression was independent of CNV. Moreover, patients with low FOXQ1 …
FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by promoting beta-catenin nuclear translocation.
Yang M, Liu Q, Dai M, Peng R, Li X, Zuo W, Gou J, Zhou F, Yu S, Liu H, Huang M. Yang M, et al. J Exp Clin Cancer Res. 2022 Feb 19;41(1):70. doi: 10.1186/s13046-021-02239-4. J Exp Clin Cancer Res. 2022. PMID: 35183223 Free PMC article.
Microarray profiling in this study revealed the differentially expressed forkhead box Q1 (FOXQ1) in CRC, and thus we aimed to illustrate the role of FOXQ1 in CRC by modulating stemness and radio-resistance of CRC cells. ...FOXQ1 overexpression contributed to …
Microarray profiling in this study revealed the differentially expressed forkhead box Q1 (FOXQ1) in CRC, and thus we aimed to illustr …
FOXQ1 promotes gastric cancer metastasis through upregulation of Snail.
Zhang J, Liu Y, Zhang J, Cui X, Li G, Wang J, Ren H, Zhang Y. Zhang J, et al. Oncol Rep. 2016 Jun;35(6):3607-13. doi: 10.3892/or.2016.4736. Epub 2016 Apr 8. Oncol Rep. 2016. PMID: 27109028
We examined the cell biology and molecular biology changes after overexpression and knockdown of FOXQ1 in gastric cancer cells in vitro. To further understand the underlying mechanisms of EMT promoted by FOXQ1, we examined the changes of target genes of FOXQ1 …
We examined the cell biology and molecular biology changes after overexpression and knockdown of FOXQ1 in gastric cancer cells in vit …
Foxq1 promotes metastasis of nasopharyngeal carcinoma by inducing vasculogenic mimicry via the EGFR signaling pathway.
Luo Y, Wang J, Wang F, Liu X, Lu J, Yu X, Ma X, Peng X, Li X. Luo Y, et al. Cell Death Dis. 2021 Apr 19;12(5):411. doi: 10.1038/s41419-021-03674-z. Cell Death Dis. 2021. PMID: 33875643 Free PMC article.
Vasculogenic mimicry (VM) is a new blood-supply model of malignant tumor that is closely related to tumors' distant metastasis. Our previous study demonstrated that miR-124 could target Foxq1 to inhibit NPC metastasis. Whether Foxq1 affects metastasis through vascul …
Vasculogenic mimicry (VM) is a new blood-supply model of malignant tumor that is closely related to tumors' distant metastasis. Our previous …
The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes.
Pizzolato G, Moparthi L, Söderholm S, Cantù C, Koch S. Pizzolato G, et al. J Cell Sci. 2022 Oct 1;135(19):jcs260082. doi: 10.1242/jcs.260082. Epub 2022 Oct 10. J Cell Sci. 2022. PMID: 36124643 Free article.
The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to-mesenchymal transition (EMT) of cancer cells. ...However, the role of FOXQ1 in the Wnt …
The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promot …
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells.
Kim SH, Singh SV. Kim SH, et al. Mol Carcinog. 2022 Mar;61(3):372-381. doi: 10.1002/mc.23381. Epub 2021 Dec 22. Mol Carcinog. 2022. PMID: 34939230 Free PMC article.
The FoxQ1 is implicated in mammary tumor progression. However, the mechanism by which FoxQ1 promotes mammary tumorigenesis is not fully understood. In this study, we present experimental evidence for a novel function of FoxQ1 in the regulation of complex I ac …
The FoxQ1 is implicated in mammary tumor progression. However, the mechanism by which FoxQ1 promotes mammary tumorigenesis is …
FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/beta-catenin signaling by binding with ANXA2.
Xiang L, Zheng J, Zhang M, Ai T, Cai B. Xiang L, et al. Stem Cell Res Ther. 2020 Sep 17;11(1):403. doi: 10.1186/s13287-020-01928-9. Stem Cell Res Ther. 2020. PMID: 32943107 Free PMC article.
METHODS: Mouse bone mesenchymal stem cells (mBMSCs) were transfected with lentivirus to generate Foxq1-overexpressing mBMSCs, Foxq1-suppressed mBMSCs, and mBMSC controls. ...Annexin A2 (ANXA2) was bound with FOXQ1, and its depletion reversed the promoting eff …
METHODS: Mouse bone mesenchymal stem cells (mBMSCs) were transfected with lentivirus to generate Foxq1-overexpressing mBMSCs, Foxq …
221 results