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Year Number of Results
1996 3
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2005 10
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2010 3
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163 results

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Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2020 Feb;45(2):279-297. doi: 10.3892/ijmm.2019.4418. Epub 2019 Dec 4. Int J Mol Med. 2020. PMID: 31894255 Free PMC article. Review.
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. ...However, Notch signaling is inactivated in small-cell lung …
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand …
New developments in the management of achondroplasia.
Högler W, Ward LM. Högler W, et al. Wien Med Wochenschr. 2020 Apr;170(5-6):104-111. doi: 10.1007/s10354-020-00741-6. Epub 2020 Mar 6. Wien Med Wochenschr. 2020. PMID: 32144686 Free PMC article. Review.
Achondroplasia is the most common form of disproportionate short stature. A dominantly inherited FGFR3 mutation permanently activates the fibroblast growth factor receptor 3 (FGFR3) and its downstream mitogen-activated protein kinase (MAPK) signalling pathway …
Achondroplasia is the most common form of disproportionate short stature. A dominantly inherited FGFR3 mutation permanently ac …
Proteogenomic Characterization of Bladder Cancer Reveals Sensitivity to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand in FGFR3-mutated Tumors.
Groeneveld CS, Sanchez-Quiles V, Dufour F, Shi M, Dingli F, Nicolle R, Chapeaublanc E, Poullet P, Jeffery D, Krucker C, Maillé P, Vacherot F, Vordos D, Benhamou S, Lebret T, Micheau O, Zinovyev A, Loew D, Allory Y, de Reyniès A, Bernard-Pierrot I, Radvanyi F. Groeneveld CS, et al. Eur Urol. 2024 May;85(5):483-494. doi: 10.1016/j.eururo.2023.05.037. Epub 2023 Jun 27. Eur Urol. 2024. PMID: 37380559 Free article.
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Proteomic groups from unsupervised analyses (uPGs) were characterized using clinicopathological, proteomic, genomic, transcriptomic, and pathway enrichment analyses. Additional enrichment analyses were performed for FGFR3-m …
OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Proteomic groups from unsupervised analyses (uPGs) were characterized using clinicopathologic …
FGFR3 biology and skeletal disease.
Narayana J, Horton WA. Narayana J, et al. Connect Tissue Res. 2015 Nov;56(6):427-33. doi: 10.3109/03008207.2015.1051224. Epub 2015 Jul 29. Connect Tissue Res. 2015. PMID: 26075305
Fibroblast Growth Factor Receptor 3 (FGFR3) is one of four high-affinity receptors for canonical FGF ligands. ...Triggered by ligand binding or in some cases mutation, FGFR3 activation involves dimerization of receptor monomers, phosphorylation …
Fibroblast Growth Factor Receptor 3 (FGFR3) is one of four high-affinity receptors for canonical FGF ligands. ...Triggered by …
The A391E mutation enhances FGFR3 activation in the absence of ligand.
Chen F, Degnin C, Laederich M, Horton WA, Hristova K. Chen F, et al. Biochim Biophys Acta. 2011 Aug;1808(8):2045-50. doi: 10.1016/j.bbamem.2011.04.007. Epub 2011 Apr 22. Biochim Biophys Acta. 2011. PMID: 21536014 Free PMC article.
Here we further test the hypothesis, by investigating the effect of the A391E mutation on the activation of full-length fibroblast growth factor receptor 3 in human embryonic kidney 293T cells in the absence of ligand. We find that the mutation enhances the …
Here we further test the hypothesis, by investigating the effect of the A391E mutation on the activation of full-length fibroblast gr …
Correlation between fibroblast growth factor receptor mutation, programmed death ligand-1 expression and survival in urinary bladder cancer based on real-world data.
Revesz J, Posfai B, Pajor L, Papdan T, Varga L, Paczona VR, Varga Z, Sukosd F, Maraz A. Revesz J, et al. Pathol Oncol Res. 2023 Apr 21;29:1611077. doi: 10.3389/pore.2023.1611077. eCollection 2023. Pathol Oncol Res. 2023. PMID: 37151354 Free PMC article.
The impact of Fibroblast Growth Factor Receptor 3 (FGFR3) mutation on the effectiveness of PD-L1 treatment remains still unclear. ...In T0 cases FGFR3 mutations were analyzed from the earlier resection samples. ...
The impact of Fibroblast Growth Factor Receptor 3 (FGFR3) mutation on the effectiveness of PD-L1 treatment remains still uncle …
Molecular therapeutic strategies for FGFR3 gene-related skeletal dysplasia.
Chen J, Liu J, Zhou Y, Liu S, Liu G, Zuo Y, Wu Z, Wu N, Qiu G. Chen J, et al. J Mol Med (Berl). 2017 Dec;95(12):1303-1313. doi: 10.1007/s00109-017-1602-9. Epub 2017 Oct 23. J Mol Med (Berl). 2017. PMID: 29063142 Review.
Gain-of-function mutations result in constitutively activated FGFR3, leading to aberrant signal transduction, and accounting for inhibition of chondrocyte proliferation and differentiation. Generally, these pathogenic mutations maintain FGFR3 in an act …
Gain-of-function mutations result in constitutively activated FGFR3, leading to aberrant signal transduction, and accounting f …
Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.
Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng CX. Chen L, et al. J Clin Invest. 1999 Dec;104(11):1517-25. doi: 10.1172/JCI6690. J Clin Invest. 1999. PMID: 10587515 Free PMC article.
Missense mutations in fibroblast growth factor receptor 3 (FGFR3) result in several human skeletal dysplasias, including the most common form of dwarfism, achondroplasia. Here we show that a glycine-to-cysteine substitution at position 375 (Gly375Cys) in human FG …
Missense mutations in fibroblast growth factor receptor 3 (FGFR3) result in several human skeletal dysplasias, including the m …
Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.
Garcia S, Dirat B, Tognacci T, Rochet N, Mouska X, Bonnafous S, Patouraux S, Tran A, Gual P, Le Marchand-Brustel Y, Gennero I, Gouze E. Garcia S, et al. Sci Transl Med. 2013 Sep 18;5(203):203ra124. doi: 10.1126/scitranslmed.3006247. Sci Transl Med. 2013. PMID: 24048522
Achondroplasia is a rare genetic disease characterized by abnormal bone development, resulting in short stature. It is caused by a single point mutation in the gene coding for fibroblast growth factor receptor 3 (FGFR3), which leads to prolonged activation upon l …
Achondroplasia is a rare genetic disease characterized by abnormal bone development, resulting in short stature. It is caused by a single po …
An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.
Kimura T, Bosakova M, Nonaka Y, Hruba E, Yasuda K, Futakawa S, Kubota T, Fafilek B, Gregor T, Abraham SP, Gomolkova R, Belaskova S, Pesl M, Csukasi F, Duran I, Fujiwara M, Kavkova M, Zikmund T, Kaiser J, Buchtova M, Krakow D, Nakamura Y, Ozono K, Krejci P. Kimura T, et al. Sci Transl Med. 2021 May 5;13(592):eaba4226. doi: 10.1126/scitranslmed.aba4226. Sci Transl Med. 2021. PMID: 33952673
Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosine kinase. The clinical need for a safe and effective inhibitor of FGFR3 is unmet, leaving achondroplasia currently incurable. Here, w …
Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosin …
163 results