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43 results

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Page 1
FCHO1(560-571) peptide, a PKB kinase motif, inhibits tumor progression.
Park S, Hong Y, Lee S, Lee AY, Tran Q, Lee H, Kim M, Park J, Cho MH, Park J. Park S, et al. Biochem Biophys Res Commun. 2020 Jul 30;528(3):478-484. doi: 10.1016/j.bbrc.2020.05.173. Epub 2020 Jun 4. Biochem Biophys Res Commun. 2020. PMID: 32507602
BACKGROUND: Cell division is regulated by protein kinase B (PKB)-mediated FCH domain only 1 (FCHO1) phosphorylation. METHODS: FCHO1(560-571), a synthetic water-soluble peptide, was generated from the PKB substrate motif (560)PPRRLRSRKVSC(571) found in the human F …
BACKGROUND: Cell division is regulated by protein kinase B (PKB)-mediated FCH domain only 1 (FCHO1) phosphorylation. METHODS: FCHO …
FCH domain only 1 (FCHo1), a potential new biomarker for lung cancer.
Park S, Lee AY, Cho KC, Jung JH, Hong SH, Kim S, Kim KP, Park J, Cho MH. Park S, et al. Cancer Gene Ther. 2022 Jul;29(7):901-907. doi: 10.1038/s41417-021-00376-8. Epub 2021 Aug 19. Cancer Gene Ther. 2022. PMID: 34413495
FCHo1 knockdown has previously been shown to cause cell death in lung cancer. However, the specific roles of FCHo1 in lung carcinoma remain elusive. Herein, we propose that FCHo1's intracellular mechanism targets the G1 to S phase transition, following the M …
FCHo1 knockdown has previously been shown to cause cell death in lung cancer. However, the specific roles of FCHo1 in lung car …
Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells.
Łyszkiewicz M, Ziętara N, Frey L, Pannicke U, Stern M, Liu Y, Fan Y, Puchałka J, Hollizeck S, Somekh I, Rohlfs M, Yilmaz T, Ünal E, Karakukcu M, Patiroğlu T, Kellerer C, Karasu E, Sykora KW, Lev A, Simon A, Somech R, Roesler J, Hoenig M, Keppler OT, Schwarz K, Klein C. Łyszkiewicz M, et al. Nat Commun. 2020 Feb 25;11(1):1031. doi: 10.1038/s41467-020-14809-9. Nat Commun. 2020. PMID: 32098969 Free PMC article.
The consequences of mutations in FCHO1 in humans were unknown. We identify ten unrelated patients with variable T and B cell lymphopenia, who are homozygous for six distinct mutations in FCHO1. ...Internalisation of the TCR receptor is severely perturbed in FCHO1 …
The consequences of mutations in FCHO1 in humans were unknown. We identify ten unrelated patients with variable T and B cell lymphope …
Transient Fcho1/2Eps15/RAP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.
Ma L, Umasankar PK, Wrobel AG, Lymar A, McCoy AJ, Holkar SS, Jha A, Pradhan-Sundd T, Watkins SC, Owen DJ, Traub LM. Ma L, et al. Dev Cell. 2016 Jun 6;37(5):428-43. doi: 10.1016/j.devcel.2016.05.003. Epub 2016 May 26. Dev Cell. 2016. PMID: 27237791 Free PMC article.
Using cells lacking FCHO1/2 and with Eps15 sequestered from the plasma membrane, we establish that without these two endocytic pioneers, AP-2 assemblies are fleeting and endocytosis stalls. Thus, distinct DPF-based codes within the unstructured Eps15/R C terminus direct th …
Using cells lacking FCHO1/2 and with Eps15 sequestered from the plasma membrane, we establish that without these two endocytic pionee …
Inflammatory Bowel Disease and Guillain Barre Syndrome in FCHO1 Deficiency.
Aydemir S, Islek A, Nepesov S, Yaman Y, Baysoy G, Beser OF, Cokugras FC, Baris S, Karakoc-Aydiner E, Cokugras H, Hubrack SZ, Kendir Demirkol Y, Lo B, Kiykim A, Ozen A. Aydemir S, et al. J Clin Immunol. 2021 Aug;41(6):1406-1410. doi: 10.1007/s10875-021-01042-2. Epub 2021 May 5. J Clin Immunol. 2021. PMID: 33950325 No abstract available.
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM. Umasankar PK, et al. Nat Cell Biol. 2012 Apr 8;14(5):488-501. doi: 10.1038/ncb2473. Nat Cell Biol. 2012. PMID: 22484487 Free PMC article.
Here, we show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub. Translational silencing of fcho1 in zebrafish embryos causes strong dorsoventral patterning defects analogous to Bmp signal failure. ...Our data thus challenge the primacy …
Here, we show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub. Translational silencing of fcho1 …
Eps15 membrane-binding and -bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis.
Wang L, Johnson A, Hanna M, Audhya A. Wang L, et al. Mol Biol Cell. 2016 Sep 1;27(17):2675-87. doi: 10.1091/mbc.E16-03-0151. Epub 2016 Jul 6. Mol Biol Cell. 2016. PMID: 27385343 Free PMC article.
In Caenorhabditis elegans, the prototypical AP-2 adaptor complex, which is activated by the accessory factor Fcho1 at the plasma membrane, is dispensable during embryogenesis, enabling us to define alternative mechanisms that facilitate clathrin-mediated endocytosis. Here …
In Caenorhabditis elegans, the prototypical AP-2 adaptor complex, which is activated by the accessory factor Fcho1 at the plasma memb …
Author Correction: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells.
Łyszkiewicz M, Ziętara N, Frey L, Pannicke U, Stern M, Liu Y, Fan Y, Puchałka J, Hollizeck S, Somekh I, Rohlfs M, Yilmaz T, Ünal E, Karakukcu M, Patiroğlu T, Kellerer C, Karasu E, Sykora KW, Lev A, Simon A, Somech R, Roesler J, Hoenig M, Keppler OT, Schwarz K, Klein C. Łyszkiewicz M, et al. Nat Commun. 2020 Apr 20;11(1):1963. doi: 10.1038/s41467-020-15946-x. Nat Commun. 2020. PMID: 32312977 Free PMC article.
Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation.
Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K. Sakaushi S, et al. Biosci Biotechnol Biochem. 2007 Jul;71(7):1764-8. doi: 10.1271/bbb.60720. Epub 2007 Jul 7. Biosci Biotechnol Biochem. 2007. PMID: 17617719 Free article.
The intracellular behavior of human FCHO1 protein was investigated by live-cell imaging microscopy. The fluorescence intensity of green fluorescent protein (GFP)-FCHO1 fluctuated periodically in a perinuclear region approximately every 100 s, reminding us of the per …
The intracellular behavior of human FCHO1 protein was investigated by live-cell imaging microscopy. The fluorescence intensity of gre …
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.
Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, Notarangelo LD. Calzoni E, et al. J Allergy Clin Immunol. 2019 Jun;143(6):2317-2321.e12. doi: 10.1016/j.jaci.2019.02.014. Epub 2019 Feb 26. J Allergy Clin Immunol. 2019. PMID: 30822429 Free PMC article.
FCHO1 deficiency is a novel autosomal recessive combined immune deficiency with impaired clathrin-mediated endocytosis...
FCHO1 deficiency is a novel autosomal recessive combined immune deficiency with impaired clathrin-mediated endocytosis...
43 results