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2007 1
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16 results

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An FBXO40 knockout generated by CRISPR/Cas9 causes muscle hypertrophy in pigs without detectable pathological effects.
Zou Y, Li Z, Zou Y, Hao H, Li N, Li Q. Zou Y, et al. Biochem Biophys Res Commun. 2018 Apr 15;498(4):940-945. doi: 10.1016/j.bbrc.2018.03.085. Epub 2018 Mar 15. Biochem Biophys Res Commun. 2018. PMID: 29545179
The expression of Fbxo40 is restricted to muscle, and mice with an Fbxo40 null mutation exhibit muscle hypertrophy. However, the function of FBXO40 has not been elucidated in pigs, and it is not known whether FBXO40 mutations affect their health. ...
The expression of Fbxo40 is restricted to muscle, and mice with an Fbxo40 null mutation exhibit muscle hypertrophy. However, t …
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40.
Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE. Zhang L, et al. Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E625-E635. doi: 10.1152/ajpendo.00480.2019. Epub 2020 Feb 26. Am J Physiol Endocrinol Metab. 2020. PMID: 32101031 Free PMC article.
Evidence that Stat3 activates Fbxo40 includes 1) potential Stat3 binding sites in Fbxo40 promoters; 2) Stat3 binding to the Fbxo40 promoter; and 3) constitutively active Stat3 stimulating both Fbxo40 expression and its promoter activity. We found that …
Evidence that Stat3 activates Fbxo40 includes 1) potential Stat3 binding sites in Fbxo40 promoters; 2) Stat3 binding to the …
FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
Ye J, Zhang Y, Xu J, Zhang Q, Zhu D. Ye J, et al. Gene. 2007 Dec 1;404(1-2):53-60. doi: 10.1016/j.gene.2007.08.020. Epub 2007 Sep 7. Gene. 2007. PMID: 17928169
By overexpressing in C2C12 cells, FBXO40 localized in cytoplasm. Most importantly, the expression of FBXO40 can be upregulated in skeletal muscle from denervation- but not starvation-related muscle atrophy. All our data suggest that FBXO40 may function as a r …
By overexpressing in C2C12 cells, FBXO40 localized in cytoplasm. Most importantly, the expression of FBXO40 can be upregulated …
The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ. Shi J, et al. Dev Cell. 2011 Nov 15;21(5):835-47. doi: 10.1016/j.devcel.2011.09.011. Epub 2011 Oct 25. Dev Cell. 2011. PMID: 22033112 Free article.
In skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating this rapid turnover of IRS1, since IRS1 loss can be rescued by knockdown of Fbxo40. ...Fbxo40 is muscle specific in …
In skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as …
Molecular characterization and association analysis of FBXO40 with partial hematological indexes in pig.
Wang ZW, Li XY, Tang ZL, Yang SL, Ying ZZ, Fu T, Fan B, Mu YL, Ao H, Li K. Wang ZW, et al. Mol Biol Rep. 2010 Oct;37(7):3393-400. doi: 10.1007/s11033-009-9928-1. Epub 2009 Nov 27. Mol Biol Rep. 2010. PMID: 19943117
F-box proteins are quite significant ubiquitin-proteasome pathway regulators in eukaryotic cells. FBXO40, a member of this large family, alters its expression pattern in muscle atrophy. ...Moreover, a HindII (HincII)-RFLP (A/C) polymorphism in 3'-untranslated region (3'-UT …
F-box proteins are quite significant ubiquitin-proteasome pathway regulators in eukaryotic cells. FBXO40, a member of this large fami …
Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly.
Stepanov V, Vagaitseva K, Bocharova A, Marusin A, Markova V, Minaycheva L, Makeeva O. Stepanov V, et al. Int J Alzheimers Dis. 2018 Apr 19;2018:2686045. doi: 10.1155/2018/2686045. eCollection 2018. Int J Alzheimers Dis. 2018. PMID: 29850221 Free PMC article.
Rs1021261 in the LUZP2 and rs3772130 in the FBXO40 were genotyped by multiplex PCR and MALDI-TOF mass spectrometry in a sample of 708 normal elderly subjects tested for cognitive performance using the Montreal Cognitive Assessment (MoCA). ...The data of the present study s …
Rs1021261 in the LUZP2 and rs3772130 in the FBXO40 were genotyped by multiplex PCR and MALDI-TOF mass spectrometry in a sample of 708 …
Lactate inhibits interferon-α response in ovarian cancer by inducing STAT1 ubiquitin degradation.
Dong X, Lin C, Lin X, Zeng C, Zeng L, Wei Z, Zeng X, Yao J. Dong X, et al. Int Immunopharmacol. 2023 Dec;125(Pt A):111099. doi: 10.1016/j.intimp.2023.111099. Epub 2023 Oct 31. Int Immunopharmacol. 2023. PMID: 38149570
Importantly, ectopic over-expression of the Fbxo40 gene significantly inhibited the expression of ISGs in LDHA knockdown cells. In the TCGA tumor data, we observed that high expression of Fbxo40 negatively correlates with overall survival in ovarian cancer patients. …
Importantly, ectopic over-expression of the Fbxo40 gene significantly inhibited the expression of ISGs in LDHA knockdown cells. In th …
Muscle wasting: an overview of recent developments in basic research.
Palus S, von Haehling S, Springer J. Palus S, et al. Int J Cardiol. 2014 Oct 20;176(3):640-4. doi: 10.1016/j.ijcard.2014.08.086. Epub 2014 Aug 23. Int J Cardiol. 2014. PMID: 25205489 Review.
The targets include 1) E-3 ligases: TRIM32, SOCS1 and SOCS3 by involving the elongin BC ubiquitin-ligase, Cbl-b, culling 7, Fbxo40, MG53 (TRIM72) and the mitochondrial Mul1, 2) the kinase MST1 and 3) the G-protein Galphai2. ...
The targets include 1) E-3 ligases: TRIM32, SOCS1 and SOCS3 by involving the elongin BC ubiquitin-ligase, Cbl-b, culling 7, Fbxo40, M …
Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training.
Stefanetti RJ, Lamon S, Wallace M, Vendelbo MH, Russell AP, Vissing K. Stefanetti RJ, et al. Pflugers Arch. 2015 Jul;467(7):1523-1537. doi: 10.1007/s00424-014-1587-y. Epub 2014 Aug 8. Pflugers Arch. 2015. PMID: 25104573
This study examined mRNA and/or protein levels of molecular markers of the ubiquitin proteasome pathway (UPP), including FBXO32 (atrogin-1), MURF-1, FBXO40, FOXO1 and FOXO3. Protein substrates of atrogin-1-including EIF3F, MYOG and MYOD1-and of MURF-1-including PKM and MHC …
This study examined mRNA and/or protein levels of molecular markers of the ubiquitin proteasome pathway (UPP), including FBXO32 (atrogin-1), …
Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise.
Stefanetti RJ, Zacharewicz E, Della Gatta P, Garnham A, Russell AP, Lamon S. Stefanetti RJ, et al. Front Physiol. 2014 Jan 31;5:30. doi: 10.3389/fphys.2014.00030. eCollection 2014. Front Physiol. 2014. PMID: 24550841 Free PMC article.
At basal, no age-related difference was observed in the gene/protein levels of atrogin-1, MURF1, myogenin, MYOD and FOXO1/3. However, a decrease in FBXO40 mRNA and protein levels was observed in older subjects, while PKM2 protein was increased. In response to RE, MURF1, at …
At basal, no age-related difference was observed in the gene/protein levels of atrogin-1, MURF1, myogenin, MYOD and FOXO1/3. However, a decr …
16 results