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2007 7
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2011 1
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2014 4
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2017 4
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74 results

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The circadian E3 ligase complex SCF(FBXL3+CRY) targets TLK2.
Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL, Kriebs A, Moresco JJ, Yates JR 3rd, Lamia KA. Correia SP, et al. Sci Rep. 2019 Jan 17;9(1):198. doi: 10.1038/s41598-018-36618-3. Sci Rep. 2019. PMID: 30655559 Free PMC article.
We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCF(FBXL3)-mediated ubiquitination of c-MYC. Because our demonstration that CRY2 recruits phosphorylated substrates to SCF(FBXL3) was unexpected, we investigated the sco …
We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCF(FBXL3)-mediated ubiquitination o …
FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer.
Wang D, Han X, Li C, Bai W. Wang D, et al. Pathol Res Pract. 2019 Feb;215(2):358-365. doi: 10.1016/j.prp.2018.12.008. Epub 2018 Dec 11. Pathol Res Pract. 2019. PMID: 30594330
The aim of this study was to discover the detailed function and molecular mechanism of F-box and leucine rich repeat protein 3 (FBXL3) in NSCLC. In this study, the expression level of FBXL3 in NSCLC tissues and cell lines was firstly examined and identified. ...The …
The aim of this study was to discover the detailed function and molecular mechanism of F-box and leucine rich repeat protein 3 (FBXL3 …
Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature.
Ansar M, Paracha SA, Serretti A, Sarwar MT, Khan J, Ranza E, Falconnet E, Iwaszkiewicz J, Shah SF, Qaisar AA, Santoni FA, Zoete V, Megarbane A, Ahmed J, Colombo R, Makrythanasis P, Antonarakis SE. Ansar M, et al. Hum Mol Genet. 2019 Mar 15;28(6):972-979. doi: 10.1093/hmg/ddy406. Hum Mol Genet. 2019. PMID: 30481285 Free PMC article.
FBXL3 (F-Box and Leucine Rich Repeat Protein 3) encodes a protein that contains an F-box and several tandem leucine-rich repeats (LRR) domains. ...No FBXL3-related phenotypes have been described in humans. By a combination of exome sequencing and homozygosity mappin …
FBXL3 (F-Box and Leucine Rich Repeat Protein 3) encodes a protein that contains an F-box and several tandem leucine-rich repeats (LRR …
CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA. Huber AL, et al. Mol Cell. 2016 Nov 17;64(4):774-789. doi: 10.1016/j.molcel.2016.10.012. Epub 2016 Nov 10. Mol Cell. 2016. PMID: 27840026 Free PMC article.
Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of cell proliferation; T58 is central in a phosphodegron long r …
Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruit …
SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.
Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N. Xing W, et al. Nature. 2013 Apr 4;496(7443):64-8. doi: 10.1038/nature11964. Epub 2013 Mar 17. Nature. 2013. PMID: 23503662 Free PMC article.
Here we report crystal structures of mammalian CRY2 in its apo, FAD-bound and FBXL3-SKP1-complexed forms. Distinct from other cryptochromes of known structures, mammalian CRY2 binds FAD dynamically with an open cofactor pocket. Notably, the F-box protein FBXL3 captu …
Here we report crystal structures of mammalian CRY2 in its apo, FAD-bound and FBXL3-SKP1-complexed forms. Distinct from other cryptoc …
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Yumimoto K, Muneoka T, Tsuboi T, Nakayama KI. Yumimoto K, et al. J Biol Chem. 2013 Nov 8;288(45):32766-32776. doi: 10.1074/jbc.M113.511303. Epub 2013 Sep 30. J Biol Chem. 2013. PMID: 24085301 Free PMC article.
Here we show that formation of the SCF(Fbxl3) complex is regulated by substrate binding in vivo. Fbxl3 did not associate with Skp1 and Cul1 to a substantial extent in transfected mammalian cells. ...A mutant form of Fbxl3 that does not bind to Cry1 was unable …
Here we show that formation of the SCF(Fbxl3) complex is regulated by substrate binding in vivo. Fbxl3 did not associate with …
Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock.
Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptácek LJ, Xu Y. Shi G, et al. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4750-5. doi: 10.1073/pnas.1302560110. Epub 2013 Mar 5. Proc Natl Acad Sci U S A. 2013. PMID: 23471982 Free PMC article.
By analyzing the Fbxl3 and Cryptochrome 1 double-mutant mice, we found that FBXL3 also regulates the amplitudes of E-box-driven gene expression. These two separate roles of FBXL3 in circadian feedback loops provide a mechanism that contributes to the period d …
By analyzing the Fbxl3 and Cryptochrome 1 double-mutant mice, we found that FBXL3 also regulates the amplitudes of E-box-drive …
A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.
Confino S, Dor T, Tovin A, Wexler Y, Ben-Moshe Livne Z, Kolker M, Pisanty O, Park SK, Geyer N, Reiter J, Edvardson S, Mor-Shaked H, Elpeleg O, Vallone D, Appelbaum L, Foulkes NS, Gothilf Y. Confino S, et al. Int J Mol Sci. 2022 Feb 21;23(4):2373. doi: 10.3390/ijms23042373. Int J Mol Sci. 2022. PMID: 35216494 Free PMC article.
By exome sequencing, we have identified a FBXL3 mutation in patients with syndromic developmental delay accompanied by morphological abnormalities and intellectual disability, albeit with a normal sleep pattern. We have investigated the function of FBXL3 in the zebr …
By exome sequencing, we have identified a FBXL3 mutation in patients with syndromic developmental delay accompanied by morphological …
lncRNA CASC2 suppresses the growth of hemangioma cells by regulating miR-18a-5p/FBXL3 axis.
Dai YX, Qiu MK, Wang SQ, Pan C, Wang Y, Ou JM. Dai YX, et al. J Biol Regul Homeost Agents. 2020 Jan-Feb;34(1):49-56. doi: 10.23812/19-526-A-FULL_ARTICLE. J Biol Regul Homeost Agents. 2020. PMID: 32138500
Moreover, lncRNA CASC2 was confirmed to bind with miR-18a-5p, which could reverse lncRNA CASC2-induced anti-proliferative effects by targeting FBXL3 in HAs cells. Altogether, our findings demonstrated that lncRNA CASC2 suppressed the growth of HAs cells by regulating miR-1 …
Moreover, lncRNA CASC2 was confirmed to bind with miR-18a-5p, which could reverse lncRNA CASC2-induced anti-proliferative effects by targeti …
74 results