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Did you mean farsad (261 results)?
Phenylalanyl-tRNA synthetase deficiency caused by biallelic variants in FARSA gene and literature review.
Guo R, Chen Y, Hu X, Qi Z, Guo J, Li Y, Hao C. Guo R, et al. BMC Med Genomics. 2023 Oct 13;16(1):245. doi: 10.1186/s12920-023-01662-0. BMC Med Genomics. 2023. PMID: 37833669 Free PMC article. Review.
Additionally, we presented the patient's detailed clinical information and compared the clinical feature with other previously reported patients with FARSA-deficiency. RESULTS: We identified compound heterozygous rare missense variants (c.1172 T > C/ p.Leu391Pro and c.1 …
Additionally, we presented the patient's detailed clinical information and compared the clinical feature with other previously reported pati …
Systemic inflammatory syndrome in children with FARSA deficiency.
Charbit-Henrion F, Goguyer-Deschaumes R, Borensztajn K, Mirande M, Berthelet J, Rodrigues-Lima F, Khiat A, Frémond ML, Bader-Meunier B, Rodari MM, Seabra L, Rice GI, Legendre M, Drummond D, Berteloot L, Roux CJ, Boddaert N, Drabent P, Molina TJ, Lacaille F, Kossorotoff M, Cerf-Bensussan N, Parlato M, Hadchouel A. Charbit-Henrion F, et al. Clin Genet. 2022 May;101(5-6):552-558. doi: 10.1111/cge.14120. Epub 2022 Feb 17. Clin Genet. 2022. PMID: 35132614 Free PMC article.
We investigated four children from two unrelated consanguineous families carrying two missense homozygous variants in FARSA with significantly reduced PheRS-mediated aminoacylation activity. ...JAK inhibition improved lung disease in one patient. Our findings expand the ge …
We investigated four children from two unrelated consanguineous families carrying two missense homozygous variants in FARSA with sign …
Fatal systemic disorder caused by biallelic variants in FARSA.
Kim SY, Ko S, Kang H, Kim MJ, Moon J, Lim BC, Kim KJ, Choi M, Choi HJ, Chae JH. Kim SY, et al. Orphanet J Rare Dis. 2022 Aug 2;17(1):306. doi: 10.1186/s13023-022-02457-9. Orphanet J Rare Dis. 2022. PMID: 35918773 Free PMC article.
This study aimed to validate the pathogenicity of variants in the FARSA gene. RESULTS: Exome sequencing revealed novel compound heterozygous variants in FARSA, P347L and R475Q, from a patient who initially presented neonatal-onset failure to thrive, liver dysfunctio …
This study aimed to validate the pathogenicity of variants in the FARSA gene. RESULTS: Exome sequencing revealed novel compound heter …
FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects.
Krenke K, Szczałuba K, Bielecka T, Rydzanicz M, Lange J, Koppolu A, Płoski R. Krenke K, et al. Clin Genet. 2019 Nov;96(5):468-472. doi: 10.1111/cge.13614. Epub 2019 Aug 6. Clin Genet. 2019. PMID: 31355908
Both detected FARSA variants are ultrarare and predicted to be damaging by in silico programs. ...Our findings indicate that a disease similar to a syndrome associated with FARSB defects can also be caused by biallelic FARSA mutations. These findings are consistent …
Both detected FARSA variants are ultrarare and predicted to be damaging by in silico programs. ...Our findings indicate that a diseas …
First Report of FARSA in the Regulation of Cell Cycle and Survival in Mantle Cell Lymphoma Cells via PI3K-AKT and FOXO1-RAG1 Axes.
Feng M, Yang K, Wang J, Li G, Zhang H. Feng M, et al. Int J Mol Sci. 2023 Jan 13;24(2):1608. doi: 10.3390/ijms24021608. Int J Mol Sci. 2023. PMID: 36675119 Free PMC article.
Herein, we found the lowest levels of FARSA in patients with MCL compared with other subtypes of lymphomas, and the same lower levels of FARSA were observed in chemoresistant MCL cell lines. Unexpectedly, despite the essential catalytic roles of FARSA, knockd …
Herein, we found the lowest levels of FARSA in patients with MCL compared with other subtypes of lymphomas, and the same lower levels …
Knockdown of circular RNA circ-FARSA restricts colorectal cancer cell growth through regulation of miR-330-5p/LASP1 axis.
Lu C, Fu L, Qian X, Dou L, Cang S. Lu C, et al. Arch Biochem Biophys. 2020 Aug 15;689:108434. doi: 10.1016/j.abb.2020.108434. Epub 2020 May 29. Arch Biochem Biophys. 2020. PMID: 32473899
Knockdown of circ-FARSA inhibited the proliferation, migration, and invasion of CRC cells in vitro. ...In addition, circ-FARSA regulated the expression of LIM and SH3 protein 1 (LASP1) by sponging miR-330-5p. ...
Knockdown of circ-FARSA inhibited the proliferation, migration, and invasion of CRC cells in vitro. ...In addition, circ-FARSA
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA.
Malnar Črnigoj M, Čerček U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B. Malnar Črnigoj M, et al. Nat Commun. 2023 Sep 16;14(1):5764. doi: 10.1038/s41467-023-41511-3. Nat Commun. 2023. PMID: 37717009 Free PMC article.
Here we identify phenylalanine-tRNA synthetase (FARS) subunit alpha (FARSA) as the main interactor of the CCCCGG antisense repeat RNA in cytosol. ...Remarkably, this is associated with global reduction of phenylalanine incorporation in the proteome and decrease in expressi …
Here we identify phenylalanine-tRNA synthetase (FARS) subunit alpha (FARSA) as the main interactor of the CCCCGG antisense repeat RNA …
SOX9-activated FARSA-AS1 predetermines cell growth, stemness, and metastasis in colorectal cancer through upregulating FARSA and SOX9.
Zhou T, Wu L, Ma N, Tang F, Yu Z, Jiang Z, Li Y, Zong Z, Hu K. Zhou T, et al. Cell Death Dis. 2020 Dec 14;11(12):1071. doi: 10.1038/s41419-020-03273-4. Cell Death Dis. 2020. PMID: 33318478 Free PMC article.
Notably, we testified that FARSA-AS1 aggravated the malignancy in CRC by enhancing SOX9 and FARSA. Our study unveiled a mechanism of SOX9-FARSA-AS1-SOX9/FARSA loop in CRC, which provides some clews of promising targets for CRC....
Notably, we testified that FARSA-AS1 aggravated the malignancy in CRC by enhancing SOX9 and FARSA. Our study unveiled a mechan …
FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway.
Wang Y, Wang G, Hu S, Yin C, Zhao P, Zhou X, Shao S, Liu R, Hu W, Liu GL, Ke W, Song Z. Wang Y, et al. Int J Mol Sci. 2023 Nov 24;24(23):16709. doi: 10.3390/ijms242316709. Int J Mol Sci. 2023. PMID: 38069034 Free PMC article.
Human phenylalanine tRNA synthetase (PheRS) comprises two alpha catalytic subunits encoded by the FARSA gene and two beta regulatory subunits encoded by the FARSB gene. ...
Human phenylalanine tRNA synthetase (PheRS) comprises two alpha catalytic subunits encoded by the FARSA gene and two beta regulatory …
α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain.
Ho MT, Lu J, Vazquez-Pianzola P, Suter B. Ho MT, et al. PLoS Genet. 2022 Apr 29;18(4):e1010185. doi: 10.1371/journal.pgen.1010185. eCollection 2022 Apr. PLoS Genet. 2022. PMID: 35486661 Free PMC article.
The alpha subunit of the cytoplasmic Phenylalanyl tRNA synthetase (alpha-PheRS, FARSA in humans) displays cell growth and proliferation activities and its elevated levels can induce cell fate changes and tumor-like phenotypes that are neither dependent on the canonical fun …
The alpha subunit of the cytoplasmic Phenylalanyl tRNA synthetase (alpha-PheRS, FARSA in humans) displays cell growth and proliferati …
40 results